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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
Other AURKA 133
Other AURKB 77
CMGC CDC2 4
CMGC CDK4 6
CMGC CDK7 2.7.11.23
CMGC CDK9 2.7.11.23
TK LCK 245
Other PLK1 53
AGC ROCK1 76
TK SRC 270
TK ZAP70 338
----FQKVEKIGEGTYGVVYKARNK--LTGEVVALKKIRLDT-ETE---GV--PSTAIR---EISLLKELN---HPNIVKLLDVIHT--------ENKLYLVFEFLHQ-DLKKFMDA-SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF------GVPVRTYTH---EVVTLWYRAPEILL---GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RISAKAALAHPFF
----FEIGRPLGKGKFGNVYLAREK--QSKFILALKVLFKAQLEKA---GV--EHQLRR---EVEIQSHLR---HPNILRLYGYFHD--------ATRVYLILEYAPLGTVYRELQ---KLS---KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV--------HAPSSRRTT---LCGTLDYLPPEMIE----GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVT-----------------------------EGARDLISRLLKHNPSQ--RPMLREVLEHPWI
----FEIGRPLGKGKFGNVYLAREK--KSHFIVALKVLFKSQ-IEK---EG--VEHQLR--REIEIQAHLH---HPNILRLYNYFYD--------RRRIYLILEYAPRGELYKELQ---KSC---TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSV--------HAPSLRRKT---MCGTLDYLPPEMIE----GRMHNEKVDLWCIGVLCYELLV-GNPPFESA---SHNETYRRIVKVDLKFPASVP-----------------------------MGAQDLISKLLRHNPSE--RLPLAQVSAHPWV
----YTKIEKIGEGTYGVVYKGRHK--TTGQVVAMKKIRLES-EEE---GV--PSTAIR---EISLLKELR---HPNIVSLQDVLMQ--------DSRLYLIFEFLSM-DLKKYLDSIPPGQ---YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF------GIPIRVYTH---EVVTLWYRSPEVLL---GSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP---GSLASHVKNLDENGLDLLSKMLIYDPAK--RISGKMALNHPYF
---Y-EPVAEIGVGAYGTVYKARDP--HSGHFVALKSVRVPN-GGGGGGGL--PISTVR---EVALLRRLEAFEHPNVVRLMDVCATSR---TDREIKVTLVFEHVDQ-DLRTYLDK-APPP---GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI-------YSYQMALTP---VVVTLWYRAPEVLL----QSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR-----PVQSVVPEMEESGAQLLLEMLTFNPHK--RISAFRALQHSYL
----YEKLDFLGEGQFATVYKARDK--NTNQIVAIKKIKLGH-RSE---AK--DGINRTALREIKLLQELS---HPNIIGLLDAFGH--------KSNISLVFDFMET-DLEVIIK--DNSL---VLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSF------GSPNRAYTH---QVVTRWYRAPELLF---GARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPG----IPLHHIFSAAGDDLLDLIQGLFLFNPCA--RITATQALKMKYF
----YEKLAKIGQGTFGEVFKARHR--KTGQKVALKKVLMEN-EKE---GF--PITALR---EIKILQLLK---HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLS--NVLV---KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSL--AKNSQPNRYTN---RVVTLWYRPPELLL---GERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQ--RIDSDDALNHDFF
----LKLVERLGAGQFGEVWMGYYN---GHTKVAVKSLK-QG-SM----SP--DAFL-A---EANLMKQLQ---HQRLVRLYAVVT---------QEPIYIITEYMENGSLVDFLK----TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI------E--DNEYTAREGAKFPIKWTAPEAIN----YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP-------------------------------EELYQLMRLCWKERPED--RPTFDYLRSV--L
--YV--RGRFLGKGGFAKCFEISDA--DTKEVFAGKIVPKSL-LLK---PH--QREKMS--MEISIHRSLA---HQHVVGFHGFFED--------NDFVFVVLELCRRRSLLELHK---RRK---ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKV------EYDGERKKT---LCGTPNYIAPEVLS----KKGHSFEVDVWSIGCIMYTLLV-GKPPFETS---CLKETYLRIKKNEYSIPKHIN-----------------------------PVAASLIQKMLQTDPTA--RPTINELLNDEFF
----YEVVKVIGRGAFGEVQLVRHK--STRKVYAMKLLSKFE-MIK---RS--DSAFFW--EERDIMAFAN---SPWVVQLFYAFQD--------DRYLYMVMEYMPGGDLVNLMS----NY---DVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKM-----NKEGMVRCDT---AVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLV-GDTPFYAD---SLVGTYSKIMNHKNSLTFPDDNDIS-------------------------KEAKNLICAFLTDREVRLGRNGVEEIKRHLFF
---L-RLEVKLGQGCFGEVWMGTWN---GTTRVAIKTLK-PG-TM----SP--EAFL-Q---EAQVMKKLR---HEKLVQLYAVVS---------EEPIYIVTEYMSKGSLLDFLK----GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI------E--DNEYTARQGAKFPIKWTAPEAAL----YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP-------------------------------ESLHDLMCQCWRKEPEE--RPTFEYLQAF--L
LIAD----IELGCGNFGSVRQGVYRMRKKQIDVAIKVLK-QG-TE----KADTEEMM-R---EAQIMHQLD---NPYIVRLIGVCQ---------AEALMLVMEMAGGGPLHKFLV----GK-REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKAL--GA--D--DSYYTARSAGKWPLKWYAPECIN----FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP-------------------------------PELYALMSDCWIYKWED--RPDFLTVEQR--M
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