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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
CMGC CDC2 4
CMGC CDK4 6
CMGC CLK4 159
TK FGFR1 478
TK JAK1 875
TK JAK2 849
TK JAK3 822
CMGC MAPK14 24
TK SRC 270
-FQKVEKIGEGTYGVVYKARNK-------L-TGEVVALKKIRLDTETE---GV--PSTAIREISLLKEL-N---HPN----IVKLLDVIH--T------ENK--LYLVFEFLHQ-DLKKFMDA-SALT-----------------GI--PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAI-------------------KLADFGLARAF--GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
-YTKIEKIGEGTYGVVYKGRHK-------T-TGQVVAMKKIRLESEEE---GV--PSTAIREISLLKEL-R---HPN----IVSLQDVLM--Q------DSR--LYLIFEFLSM-DLKKYLDSIPPGQ-----------------YM--DSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTI-------------------KLADFGLARAF--GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPL---------------FHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP---------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--
Y-EPVAEIGVGAYGTVYKARDP-------H-SGHFVALKSVRVPNGGGGGGGL--PISTVREVALLRRL-EAFEHPN----VVRLMDVCA--TSR-TDREIK--VTLVFEHVDQ-DLRTYLDK-APPP-----------------GL--PAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTV-------------------KLADFGLARI---YSYQMALTP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPL---------------FCGN-SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR-----------------PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL--
-YEIVDTLGEGAFGKVVECIDH-------GMDGMHVAVKIVKNVGRYR---EA--ARS---EIQVLEHL-NS-TDPNSVFRCVQMLEWFD--H------HGH--VCIVFELLGL-STYDFIK---ENS-----------------FLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA-----TYDDEHHST---LVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYL-GFTV---------------FQTH-DSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFF--
L-VLGKPLGEGCFGQVVLAEAIGLDKDKPN-RVTKVAVKMLK-SDAT----EKDLSDLI-SEMEMMKMIGK---HKN----IINLLGACT--Q------DGP--LYVIVEYASKGNLREYLQ----ARRPPGLEYCYNPSHNPEEQL--SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVM-------------------KIADFGLARDI-HH--IDYYKKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSP---------------YPGV-PVEELFKLLKEGHRMDKPSNCT-------------------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL----
L-KRIRDLGEGHFGKVELCRYDP---EGDN-TGEQVAVKSLK-PESG----GNHIADLK-KEIEILRNL-Y---HEN----IVKYKGICT-ED-------GGNGIKLIMEFLPSGSLKEYLP----KN---------------KNKI--NLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQV-------------------KIGDFGLTKAIETD--KEYYTVKDDRDSPVFWYAPECLM-QSKFYIASDVWSFGVTLHELLTYCDSDSSPMALF-LKMIGPTHGQM-TVTRLVNTLKEGKRLPCPPNCP-------------------------------------------DEVYQLMRKCWEFQPSNRTSFQNLIE---GF-
-LKFLQQLGKGNFGSVEMCRYDP---LQDN-TGEVVAVKKLQ-HSTE-----EHLRDFE-REIEILKSL-Q---HDN----IVKYKGVCYSAG------RRN--LKLIMEYLPYGSLRDYLQ----KH---------------KERI--DHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRV-------------------KIGDFGLTKVLPQD--KEYYKVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCP-------------------------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
L-KYISQLGKGNFGSVELCRYDP---LGDN-TGALVAVKQLQ-HSGP----DQ-QRDFQ-REIQILKAL-H---SDF----IVKYRGVSYGPG------RQS--LRLVMEYLPSGCLRDFLQ----RH---------------RARL--DASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHV-------------------KIADFGLAKLLPLD--KDYYVVREPGQSPIFWYAPESLS-DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELLEEGQRLPAPPACP-------------------------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL-
-YQNLSPVGSGAYGSVCAAFDT-------K-TGLRVAVKKLSRPFQSI---IH--AKRTYRELRLLKHM-K---HEN----VIGLLDVFT--PARSLEEFND--VYLVTHLMGA-DLNNIVK----CQ-----------------KL--TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCEL-------------------KILDFGLAR-----HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTL---------------FPGT-DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-------------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF--
L-RLEVKLGQGCFGEVWMGTWN---------GTTRVAIKTLK-PGTM----SP--EAFL-QEAQVMKKL-R---HEK----LVQLYAVVS---------EEP--IYIVTEYMSKGSLLDFLK----GE--------------TGKYL--RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVC-------------------KVADFGLARLI--E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVP---------------YPGM-VNREVLDQVERGYRMPCPPECP-------------------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L--
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