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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
CMGC CDC2 4
CMGC CDK4 6
CMGC GSK3B 56
TK JAK2 849
TK MET 1078
CAMK PIM1 38
-FQKVEKIGEGTYGVVYKARNK----LTGEVVALKKIRLDTETE---GV--PSTAIR----EISLLKELN---HPN--IVKLLDVIH--T-----ENKLY--LVFEFLHQ---DLKKFMDA--SALT--GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF--GVPVRTY--TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
-YTKIEKIGEGTYGVVYKGRHK----TTGQVVAMKKIRLESEEE---GV--PSTAIR----EISLLKELR---HPN--IVSLQDVLM--Q-----DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ--YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAF--GIPIRVY--TH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPL---------------FHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--
Y-EPVAEIGVGAYGTVYKARDP----HSGHFVALKSVRVPNGGGGGGGL--PISTVR----EVALLRRLEAFEHPN--VVRLMDVCA--TSRTDREIKVT--LVFEHVDQ---DLRTYLDK--APPP--GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARI---YSYQMAL--TP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPL---------------FCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR--PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL--
-YTDTKVIGNGSFGVVYQAKLC----DSGELVAIKKVLQDKRFK---NR------------ELQIMRKLD---HCN--IVRLRYFFY--SSG-EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ--TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ---LVRGEPN--VS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPI---------------FPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF--
-LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ-HSTE-----EHLRDFE-R----EIEILKSLQ---HDN--IVKYKGVCYSAG-----RRNLK--LIMEYLPYG--SLRDYLQ-----KHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVE-NENRVKIGDFGLTKVLPQD--KEYY--KVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCP----------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
-VHFNEVIGRGHFGCVYHGTLL-DNDGKKIHCAVKSLN-RITD----IGEVSQFL-T----EGIIMKDFS---HPN--VLSLLGICL-RS-----EGSPL--VVLPYMKHG--DLRNFIR-----NETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLD-EKFTVKVADFGLARDM-YD--KEYYSVHNKTGAKLPVKWMALESLQ-TQKFTTKSDVWSFGVLLWELMTRGAPP---------------YPDVNTFDITVYLLQGRRLLQPEYCP----------------------------DPLYEVMLKCWHPKAEMRPSFSELVSR--I--
-YQVGPLLGSGGFGSVYSGIRV----SDNLPVAIKHVEKDRISD---WG--ELPNGTRVPMEVVLLKKVS---SGFSGVIRLLDWFE--R-----PDSFV--LILERPEPV-QDLFDFIT----ERG--ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA----LLKDTVY--TD---FDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIP---------------FEHD---------EEIIRGQVFFRQRVS--------------------------SECQHLIRWCLALRPSDRPTFEEIQNHPWM--
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