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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
Other AURKB 77
CAMK CHEK1 9
CMGC GSK3B 56
TK JAK2 849
TK JAK3 822
TK LCK 245
CMGC MAPK8 26
CAMK PIM1 38
AGC PRKACA 44
AGC ROCK2 92
Other TTK 525
-FQKVEKIGEGTYGVVYKARNK----LTGEVVALKKIRLDTETEGV--PSTAIR----EISLLKEL-N-HPN--IVKLLDVIH--T------ENKLY--LVFEFLHQ---DLKKFMDA--SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEILL----------GCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RIS-----AKAALAHPFF--
-FEIGRPLGKGKFGNVYLAREK----KSHFIVALKVLFKSQIEKEG--VEHQLR---REIEIQAHL-H-HPN--ILRLYNYFY--D------RRRIY--LILEYAPRG--ELYKELQ----KSC---TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGELKIADFGWSV------HAPSLRRKT---MCGTLDYLPPEMIE-----------GRMHNEKVDLWCIGVLCYELLV-GNPP---------------FESA----SHNETYRRIVKVDLKFPASVP---------------------------------------MGAQDLISKLLRHNPSE--RLP-----LAQVSAHPWV--
W-DLVQTLGEGAYGEVQLAVNR----VTEEAVAVKIVDMKRAVDCP--ENI-KK----EICINKML-N-HEN--VVKFYGHRR--E------GNIQY--LFLEYCSGG--ELFDRIE----PDI---GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNLKISDFGLATVFR--YNNRERLLNK---MCGTLPYVAPELLK----------RREFHAEPVDVWSCGIVLTAMLA-GELP---------------WDQP---SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------SAPLALLHKILVENPSA--RIT-----IPDIKKDRW-Y-
-YTDTKVIGNGSFGVVYQAKLC----DSGELVAIKKVLQDKRFKNR------------ELQIMRKL-D-HCN--IVRLRYFFY--SSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ---TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-----LVRGEPNVS---YICSRYYRAPELIF----------GATDYTSSIDVWSAGCVLAELLL-GQPI---------------FPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTA--RLT-----PLEACAHSFF--
-LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ-HSTE--EHLRDFE-R----EIEILKSL-Q-HDN--IVKYKGVCYSAG------RRNLK--LIMEYLPYG--SLRDYLQ-----KH-KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVE-NENRVKIGDFGLTKVL-PQ-D--KEYYKVKEPGESPIFWYAPESLT-----------ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCP-----------------------------------------DEIYMIMTECWNNNVNQ--RPS-----FRDLA----LRV
L-KYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQ-HSGP-DQ-QRDFQ-R----EIQILKAL-H-SDF--IVKYRGVSYGPG------RQSLR--LVMEYLPSG--CLRDFLQ-----RH-RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVE-SEAHVKIADFGLAKLL-PL-D--KDYYVVREPGQSPIFWYAPESLS-----------DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELLEEGQRLPAPPACP-----------------------------------------AEVHELMKLCWAPSPQD--RPS-----FSALGP---QL-
-LKLVERLGAGQFGEVWMGYYN-----GHTKVAVKSLK-QGSM-SP--DAFL-A----EANLMKQL-Q-HQR--LVRLYAVVT---------QEPIY--IITEYMENG--SLVDFLK-----TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSCKIADFGLARLI----E--DNEYTAREGAKFPIKWTAPEAIN-----------YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNLERGYRMVRPDNCP-----------------------------------------EELYQLMRLCWKERPED--RPT-----FDYLRSV--L--
-YQNLKPIGSGAQGIVCAAYDA----ILERNVAIKKLSRPFQNQTH--AKRAYR----ELVLMKCV-N-HKN--IIGLLNVFT--PQKSLEEFQDVY--IVMELMDA---NLCQVIQ------M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART-----AGTSFMMTP---YVVTRYYRAPEVIL-----------GMGYKENVDLWSVGCIMGEMVC-HKIL---------------FPGR-DYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASK--RIS-----VDEALQHPYI--
-YQVGPLLGSGGFGSVYSGIRV----SDNLPVAIKHVEKDRISDWG--ELPNGTRVPMEVVLLKKV-S-SGFSGVIRLLDWFE--R------PDSFV--LILERPEPV-QDLFDFIT----ERG---ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA------LLKDTVYTD---FDGTRVYSPPEWIR----------YHRYHGRSAAVWSLGILLYDMVC-GDIP---------------FEHD----------EEIIRGQVFFRQRVS---------------------------------------SECQHLIRWCLALRPSD--RPT-----FEEIQNHPWM--
F-ERIKTLGTGSFGRVMLVKHK----ETGNHYAMKILDKQKVVKLK--QIEHTL---NEKRILQAV-N-FPF--LVKLEFSFK--D------NSNLY--MVMEYVPGG--EMFSHLR----RIG---RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID-QQGYIQVTDFGFAK-------RVKGRTWT---LCGTPEYLAPEIIL-----------SKGYNKAVDWWALGVLIYEMAA-GYPP---------------FFAD----QPIQIYEKIVSGKVRFPSHFS---------------------------------------SDLKDLLRNLLQVDLTK--RFGNLKNGVNDIKNHKWF--
-YDVVKVIGRGAFGEVQLVRHK----ASQKVYAMKLLSKFEMIKRS--DSAFFW---EERDIMAFA-N-SPW--VVQLFYAFQ--D------DRYLY--MVMEYMPGG--DLVNLMS-----NY---DVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLD-KHGHLKLADFGTCMKM---DETGMVHCDT---AVGTPDYISPEVLKS-------QGGDGFYGRECDWWSVGVFLYEMLV-GDTP---------------FYAD----SLVGTYSKIMDHKNSLCFPEDAEIS-----------------------------------KHAKNLICAFLTDREVRLGRNG-----VEEIRQHPFF--
-YSILKQIGSGGSSKVFQVLNE----KKQ-IYAIKYVNLEEADNQT--LDSYRN----EIAYLNKLQQHSDK--IIRLYDYEI--T------DQYIY--MVMECGNI---DLNSWLK----KKK---SIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIV--DGMLKLIDFGIANQMQ--PDTTSVVKDS---QVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTY-GKTP---------------FQQI---INQISKLHAIIDPNHEIEFPDIPE-------------------------------------KDLQDVLKCCLKRDPKQ--RIS-----IPELLAHPYV--
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