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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
TK ABL1 261
AGC AKT1 150
Other AURKB 77
CMGC CDK4 6
Other CHUK 15
CMGC CSNK2A1 39
CMGC GSK3B 56
TK JAK2 849
TK LCK 245
CMGC MAPK14 24
CAMK PIM1 38
Other PLK1 53
AGC ROCK2 92
TK SRC 270
--FQKVEKIGEGTYGVVYKARNK----LTGEVVALKKIRLDTETE---GV--PSTAIR----EISLLKEL-N---HPN--IVKLLDVIH--T------ENKLY--LVFEFLHQ---DLKKFMDA--SALT---GIPLPLIKSYLFQLLQGLAFCHS-HRVLHRDLKPQNLLIN-TEGAI---KLADFGLARAF---GVPVRTYTH---EVVTLWYRAPEILL---GCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FP-GD-----------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--------QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RIS-----AKAALAHPFF---------
--ITMKHKLGGGQYGEVYEGVWK----KYSLTVAVKTLK-EDTM----EV--EEFL-K----EAAVMKEI-K---HPN--LVQLLGVCT--R------EPPFY--IITEFMTYG--NLLDYLR-----ECNRQEVNAVVLLYMATQISSAMEYLEK-KNFIHRDLAARNCLVG-ENHLV---KVADFGLSRLM---T--GDTYTAHAGAKFPIKWTAPESLA----YNKFSIKSDVWAFGVLLWEIATYGMSP---------------YP-GI-----------DLSQVYELLEKDYRMERPEGCP------------------------------------EKVYELMRACWQWNPSD--RPS-----FAEIHQA--F---------
-F-EYLKLLGKGTFGKVILVKEK----ATGRYYAMKILKKEVIVA---KD--EVAHTL---TENRVLQNS-R---HPF--LTALKYSFQ--T------HDRLC--FVMEYANGG--ELFFHLS----RER---VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD-KDGHI---KITDFGLCKEG---IKDGATMKT---FCGTPEYLAPEVLE----DNDYGRAVDWWGLGVVMYEMMC-GRLP---------------FY-NQ--------------DHEKLFELILMEEIRFPRTLG----------------------------------PEAKSLLSGLLKKDPKQ--RLGGGSEDAKEIMQHRFF---------
--FEIGRPLGKGKFGNVYLAREK----KSHFIVALKVLFKSQIEK---EG--VEHQLR---REIEIQAHL-H---HPN--ILRLYNYFY--D------RRRIY--LILEYAPRG--ELYKELQ----KSC---TFDEQRTATIMEELADALMYCHG-KKVIHRDIKPENLLLG-LKGEL---KIADFGWSV-----HAPSLRRKT---MCGTLDYLPPEMIE----GRMHNEKVDLWCIGVLCYELLV-GNPP---------------FE-SA--------------SHNETYRRIVKVDLKFPASVP----------------------------------MGAQDLISKLLRHNPSE--RLP-----LAQVSAHPWV---------
-Y-EPVAEIGVGAYGTVYKARDP----HSGHFVALKSVRVPNGGGGGGGL--PISTVR----EVALLRRL-EAFEHPN--VVRLMDVCA--TSR-TDREIKVT--LVFEHVDQ---DLRTYLDK--APPP---GLPAETIKDLMRQFLRGLDFLHA-NCIVHRDLKPENILVT-SGGTV---KLADFGLARI----YSYQMALTP---VVVTLWYRAPEVLL----QSTYATPVDMWSVGCIFAEMFR-RKPL---------------FC-GN-----------SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR----------PVQSVVPEMEESGAQLLLEMLTFNPHK--RIS-----AFRALQHSYL---------
-W-EMRERLGTGGFGNVCLYQHR----ELDLKIAIKSCRLELSTK---NR--ER-WCH----EIQIMKKL-N---HAN--VVKACDVPE--ELN-ILIHDVPL--LAMEYCSGG--DLRKLLNK-PENCC---GLKESQILSLLSDIGSGIRYLHE-NKIIHRDLKPENIVLQ-DVGGKIIHKIIDLGYAKD----VDQGSLCTS---FVGTLQYLAPELFE----NKPYTATVDYWSFGTMVFECIA-GYRP---------------FL-HHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSHLPQPNSLCS------------------------LVVEPMENWLQLMLNWDPQQ--RG----------------GPVDLTLKQ
--YQLVRKLGRGKYSEVFEAINI----TNNEKVVVKILKPVKKKK---IK--R---------EIKILENLRG---GPN--IITLADIVK--DP----VSRTPA--LVFEHVNNT--DFKQLY-------Q---TLTDYDIRFYMYEILKALDYCHS-MGIMHRDVKPHNVMIDHEHRKL---RLIDWGLAEF----YHPGQEYNV---RVASRYFKGPELLV---DYQMYDYSLDMWSLGCMLASMIF-RKEP---------------FFHGH-----------DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQS--RLT-----AREAMEHPYF---------
--YTDTKVIGNGSFGVVYQAKLC----DSGELVAIKKVLQDKRFK---NR------------ELQIMRKL-D---HCN--IVRLRYFFY--SSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ---TLPVIYVKLYMYQLFRSLAYIHS-FGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ----LVRGEPNVS---YICSRYYRAPELIF---GATDYTSSIDVWSAGCVLAELLL-GQPI---------------FP-GD-----------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--------PWTKVFRPRTPPEAIALCSRLLEYTPTA--RLT-----PLEACAHSFF---------
--LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ-HSTE-----EHLRDFE-R----EIEILKSL-Q---HDN--IVKYKGVCYSAG------RRNLK--LIMEYLPYG--SLRDYLQ-----KH-KERIDHIKLLQYTSQICKGMEYLGT-KRYIHRDLATRNILVE-NENRV---KIGDFGLTKVLPQ-D--KEYYKVKEPGESPIFWYAPESLT----ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQG-QM-----------IVFHLIELLKNNGRLPRPDGCP------------------------------------DEIYMIMTECWNNNVNQ--RPS-----FRDLA----LRV-------
--LKLVERLGAGQFGEVWMGYYN-----GHTKVAVKSLK-QGSM----SP--DAFL-A----EANLMKQL-Q---HQR--LVRLYAVVT---------QEPIY--IITEYMENG--SLVDFLK-----TPSGIKLTINKLLDMAAQIAEGMAFIEE-RNYIHRDLRAANILVS-DTLSC---KIADFGLARLI---E--DNEYTAREGAKFPIKWTAPEAIN----YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YP-GM-----------TNPEVIQNLERGYRMVRPDNCP------------------------------------EELYQLMRLCWKERPED--RPT-----FDYLRSV--L---------
--YQNLSPVGSGAYGSVCAAFDT----KTGLRVAVKKLSRPFQSI---IH--AKRTYR----ELRLLKHM-K---HEN--VIGLLDVFT--PARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQ---KLTDDHVQFLIYQILRGLKYIHS-ADIIHRDLKPSNLAVN-EDCEL---KILDFGLAR------HTDDEMTG---YVATRWYRAPEIML---NWMHYNQTVDIWSVGCIMAELLT-GRTL---------------FP-GT-----------DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP------KMNFANVFIGANPLAVDLLEKMLVLDSDK--RIT-----AAQALAHAYF---------
--YQVGPLLGSGGFGSVYSGIRV----SDNLPVAIKHVEKDRISD---WG--ELPNGTRVPMEVVLLKKV-S---SGFSGVIRLLDWFE--R------PDSFV--LILERPEPV-QDLFDFIT----ERG---ALQEELARSFFWQVLEAVRHCHN-CGVLHRDIKDENILIDLNRGEL---KLIDFGSGA-----LLKDTVYTD---FDGTRVYSPPEWIR---YHRYHGRSAAVWSLGILLYDMVC-GDIP---------------FE-HD--------------------EEIIRGQVFFRQRVS----------------------------------SECQHLIRWCLALRPSD--RPT-----FEEIQNHPWM---------
YV--RGRFLGKGGFAKCFEISDA----DTKEVFAGKIVPKSLLLK---PH--QREKMS---MEISIHRSL-A---HQH--VVGFHGFFE--D------NDFVF--VVLELCRRR--SLLELHK----RRK---ALTEPEARYYLRQIVLGCQYLHR-NRVIHRDLKLGNLFLN-EDLEV---KIGDFGLATKV---EYDGERKKT---LCGTPNYIAPEVLS----KKGHSFEVDVWSIGCIMYTLLV-GKPP---------------FE-TS--------------CLKETYLRIKKNEYSIPKHIN----------------------------------PVAASLIQKMLQTDPTA--RPT-----INELLNDEFF---------
--YDVVKVIGRGAFGEVQLVRHK----ASQKVYAMKLLSKFEMIK---RS--DSAFFW---EERDIMAFA-N---SPW--VVQLFYAFQ--D------DRYLY--MVMEYMPGG--DLVNLMS-----NY---DVPEKWAKFYTAEVVLALDAIHS-MGLIHRDVKPDNMLLD-KHGHL---KLADFGTCMKM--DETGMVHCDT---AVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLV-GDTP---------------FY-AD--------------SLVGTYSKIMDHKNSLCFPEDAEIS------------------------------KHAKNLICAFLTDREVRLGRNG-----VEEIRQHPFF---------
-L-RLEVKLGQGCFGEVWMGTWN-----GTTRVAIKTLK-PGTM----SP--EAFL-Q----EAQVMKKL-R---HEK--LVQLYAVVS---------EEPIY--IVTEYMSKG--SLLDFLK-----GETGKYLRLPQLVDMAAQIASGMAYVER-MNYVHRDLRAANILVG-ENLVC---KVADFGLARLI---E--DNEYTARQGAKFPIKWTAPEAAL----YGRFTIKSDVWSFGILLTELTTKGRVP---------------YP-GM-----------VNREVLDQVERGYRMPCPPECP------------------------------------ESLHDLMCQCWRKEPEE--RPT-----FEYLQAF--L---------
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