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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
TK ABL1 261
Other AURKA 133
CMGC CDC2 4
TK EPHB3 633
CMGC GSK3B 56
STE MAP2K1 68
CMGC MAPK1 13
CMGC MAPK14 24
TK SRC 270
-FQKVEKIGEGTYGVVYKARNK---LTGEVVALKKIRLDT-ETEGV--PSTAIREISLLKELNHPNIVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA--SALT---GIPLPLIKSYLFQLLQGLAFCHS-HRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF------GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
-ITMKHKLGGGQYGEVYEGVWK---KYSLTVAVKTLK-ED-TM-EV--EEFL-KEAAVMKEIKHPNLVQLLGVCTR------EPPFY--IITEFMTYG--NLLDYLR-----ECNRQEVNAVVLLYMATQISSAMEYLEK-KNFIHRDLAARNCLVG-ENHLVKVADFGLSRLM------T--GDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP-------------------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F
-FEIGRPLGKGKFGNVYLAREK---QSKFILALKVLFKAQLEKAGV--EHQLRREVEIQSHLRHPNILRLYGYFHD------ATRVY--LILEYAPLG--TVYRELQ----KLS---KFDEQRTATYITELANALSYCHS-KRVIHRDIKPENLLLG-SAGELKIADFGWSV--------HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVT-----------------------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI
-YTKIEKIGEGTYGVVYKGRHK---TTGQVVAMKKIRLES-EEEGV--PSTAIREISLLKELRHPNIVSLQDVLMQ------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ---YMDSSLVKSYLYQILQGIVFCHS-RRVLHRDLKPQNLLID-DKGTIKLADFGLARAF------GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP---------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
V-KIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLK-VG-YT-ERQRRDFL-SEASIMGQFDHPNIIRLEGVVTK------SRPVM--ILTEFMENC--ALDSFLR-----LN-DGQFTVIQLVGMLRGIAAGMKYLSE-MNYVHRDLAARNILVN-SNLVCKVSDFGLSRFLEDDP--S--DPTYTSSLGGKIPIRWTAPEAIA-YRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCP-------------------------------------------TALHQLMLDCWVRDRNLRPKFSQIVNTL--
-YTDTKVIGNGSFGVVYQAKLC---DSGELVAIKKVLQDK-RFKNR--------ELQIMRKLDHCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ---TLPVIYVKLYMYQLFRSLAYIHS-FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-------LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH---------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF
-FEKISELGAGNGGVVFKVSHK---PSGL-VMARKLIHLE-IKPAI--RNQIIRELQVLHECNSPYIVGFYGAFYS------DGEIS--ICMEHMDGG--SLDQVLK----KAG---RIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVN-SRGEIKLCDFGVSG--------QLIDSMANS---FVGTRSYMSPERLQ-GTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI
-YTNLSYIGEGAYGMVCSAYDN---VNKVRVAIKKISPFE-HQTYC--QRT-LREIKILLRFRHENIIGINDIIRAPT-IEQMKDVY--IVQDLMET---DLYKLLK-----TQ---HLSNDHICYFLYQILRGLKYIHS-ANVLHRDLKPSNLLLN-TTCDLKICDFGLARVAD---PDHDHTGFLTE---YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN-------------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL
-YQNLSPVGSGAYGSVCAAFDT---KTGLRVAVKKLSRPF-QSIIH--AKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQ---KLTDDHVQFLIYQILRGLKYIHS-ADIIHRDLKPSNLAVN-EDCELKILDFGLAR---------HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-------------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF
L-RLEVKLGQGCFGEVWMGTWN----GTTRVAIKTLK-PG-TM-SP--EAFL-QEAQVMKKLRHEKLVQLYAVVS-------EEPIY--IVTEYMSKG--SLLDFLK-----GETGKYLRLPQLVDMAAQIASGMAYVER-MNYVHRDLRAANILVG-ENLVCKVADFGLARLI------E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP-------------------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L
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