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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
CMGC CDC2 4
CMGC CDK4 6
CMGC CDK7 2.7.11.23
CMGC CDK9 2.7.11.23
-FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETE---GVPSTAIR---EISLLKELN---HPNIVKLLDVIHT--------ENKLYLVFEFLHQDLKKFMDA-SALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF----GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
-YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEE---GVPSTAIR---EISLLKELR---HPNIVSLQDVLMQ--------DSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF----GIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP---GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
Y-EPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVR---EVALLRRLEAFEHPNVVRLMDVCATSR---TDREIKVTLVFEHVDQDLRTYLDK-APPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI-----YSYQMALTPVVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR-----PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL
-YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSE---AKDGINRTALREIKLLQELS---HPNIIGLLDAFGH--------KSNISLVFDFMETDLEVIIK--DNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSF----GSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPG----IPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF
-YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKE---GFPITALR---EIKILQLLK---HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLS--NVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF
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