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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
TK ABL1 261
CMGC CDC2 4
CMGC CDK4 6
CMGC CDK5 4
Other CHUK 15
CMGC GSK3B 56
CMGC MAPK14 24
AGC PDPK1 82
AGC ROCK2 92
TK SRC 270
-FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETE---GVPS-TAIR-EISLLKELN---HPNIVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA--SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI---KLADFGLARAF--GVPVRTYTH---EVVTLWYRAPEILL---GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD-----------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RISAKAALAHPFF-----------
-ITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK-EDTM----EVEE-FL-K-EAAVMKEIK---HPNLVQLLGVCTR------EPPFY--IITEFMTYG--NLLDYLR-----ECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLV---KVADFGLSRLM--T--GDTYTAHAGAKFPIKWTAPESLA----YNKFSIKSDVWAFGVLLWEIATYGMSPYPGI-----------DLSQVYELLEKDYRMERPEGCP------------------------------EKVYELMRACWQWNPSD--RPSFAEIHQA--F-----------
-YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEE---GVPS-TAIR-EISLLKELR---HPNIVSLQDVLMQ------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ---YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI---KLADFGLARAF--GIPIRVYTH---EVVTLWYRSPEVLL---GSARYSTPVDIWSIGTIFAELAT-KKPLFHGD-----------SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP--GSLASHVKNLDENGLDLLSKMLIYDPAK--RISGKMALNHPYF-----------
Y-EPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPI-STVR-EVALLRRLEAFEHPNVVRLMDVCATSR-TDREIKVT--LVFEHVDQ---DLRTYLDK--APPP---GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTV---KLADFGLARI---YSYQMALTP---VVVTLWYRAPEVLL----QSTYATPVDMWSVGCIFAEMFR-RKPLFCGN-----------SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR----PVQSVVPEMEESGAQLLLEMLTFNPHK--RISAFRALQHSYL-----------
-YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDE---GVPS-SALR-EICLLKELK---HKNIVRLHDVLHS------DKKLT--LVFEFCDQ---DLKKYFD---SCNG---DLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL---KLADFGLARAF--GIPVRCYSA---EVVTLWYRPPDVLF---GAKLYSTSIDMWSAGCIFAELANAGRPLFPGN-----------DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT--TSLVNVVPKLNATGRDLLQNLLKCNPVQ--RISAEEALQHPYF-----------
W-EMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTK---NRER--WCH-EIQIMKKLN---HANVVKACDVPEELN-ILIHDVPL--LAMEYCSGG--DLRKLLNK-PENCC---GLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQ-DVGGKIIHKIIDLGYAKD---VDQGSLCTS---FVGTLQYLAPELFE----NKPYTATVDYWSFGTMVFECIA-GYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSHLPQPNSLCS------------------LVVEPMENWLQLMLNWDPQQ--RG-----------GPVDLTLKQ--
-YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK---NR--------ELQIMRKLD---HCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ---TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ---LVRGEPNVS---YICSRYYRAPELIF---GATDYTSSIDVWSAGCVLAELLL-GQPIFPGD-----------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--PWTKVFRPRTPPEAIALCSRLLEYTPTA--RLTPLEACAHSFF-----------
-YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSI---IHAK-RTYR-ELRLLKHMK---HENVIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQ---KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCEL---KILDFGLAR-----HTDDEMTG---YVATRWYRAPEIML---NWMHYNQTVDIWSVGCIMAELLT-GRTLFPGT-----------DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDK--RITAAQALAHAYF-----------
F-KFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIK---ENKVPYVTR-ERDVMSRLD---HPFFVKLYFTFQD------DEKLY--FGLSYAKNG--ELLKYIR----KIG---SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHI---QITDFGTAKVLSPESKQARANS---FVGTAQYVSPELLT----EKSACKSSDLWALGCIIYQLVA-GLPPFRAG--------------NEYLIFQKIIKLEYDFPEKFF----------------------------PKARDLVEKLLVLDATK--RLGCEEM------EGYGPLKAHPF
-YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIK---RSDS-AFFWEERDIMAFAN---SPWVVQLFYAFQD------DRYLY--MVMEYMPGG--DLVNLMS-----NY---DVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLD-KHGHL---KLADFGTCMKM-DETGMVHCDT---AVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLV-GDTPFYAD--------------SLVGTYSKIMDHKNSLCFPEDAEIS------------------------KHAKNLICAFLTDREVRLGRNGVEEIRQHPFF-----------
L-RLEVKLGQGCFGEVWMGTWN-GTTRVAIKTLK-PGTM----SPEA-FL-Q-EAQVMKKLR---HEKLVQLYAVVS-------EEPIY--IVTEYMSKG--SLLDFLK-----GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVC---KVADFGLARLI--E--DNEYTARQGAKFPIKWTAPEAAL----YGRFTIKSDVWSFGILLTELTTKGRVPYPGM-----------VNREVLDQVERGYRMPCPPECP------------------------------ESLHDLMCQCWRKEPEE--RPTFEYLQAF--L-----------
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