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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
TK ABL1 261
AGC AKT1 150
Other AURKA 133
TK BLK 241
CMGC CDC2 4
CMGC CDK4 6
CAMK CHEK1 9
TK FGFR1 478
TK FYN 271
CMGC GSK3B 56
TK HCK 241
TKL IRAK4 186
TK JAK1 875
TK JAK2 849
TK JAK3 822
TK LCK 245
TK LYN 247
CMGC MAPK14 24
TK MET 1078
Other PLK1 53
AGC PRKCA 339
AGC PRKCB 342
AGC RPS6KA1 62
AGC RPS6KB1 91
TK SRC 270
TK TNK2 150
TK YES1 277
TK ZAP70 338
----FQKVEKIGEGTYGVV---YKARN---K-------LTGEVVALKKIRLD--T-ETE---GV--P-STAIR--EISLLKEL--N---HPNIVKLLDVIH--T------ENK--LY--LVFEFLHQ---DLKKFMDA--SALT-----------------GIPLPLIKSYLFQLLQGLAFCHS-HRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF----GVPVRTY--TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRIS-----AKAALAHPFF--------------
----ITMKHKLGGGQYGEV---YEGVW---K-------KYSLTVAVKTLK-E--D-TM----EV--E-EFL-K--EAAVMKEI--K---HPNLVQLLGVCT--R------EPP--FY--IITEFMTYG--NLLDYLR-----EC--------------NRQEVNAVVLLYMATQISSAMEYLEK-KNFIHRDLAARNCLVG-ENHLVKVADFGLSRLM----T--GDTY--TAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-DLSQVYELL-EKDYRMERPEGCP------------------------------EKVYE-LMRACWQWNPSDRPS-----FAEIHQA--F--------------
---F-EYLKLLGKGTFGKV---ILVKE---K-------ATGRYYAMKILKKE--V-IVA---KD--E-VAHTL-TENRVLQNS--R---HPFLTALKYSFQ--T------HDR--LC--FVMEYANGG--ELFFHLS----RER-----------------VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD-KDGHIKITDFGLCKEG----IKDGATM--KT---FCGTPEYLAPEVLE-DNDYGRAVDWWGLGVVMYEMMC-GRLP---------------FYNQ----DHEKLF-ELILMEEIRFPRTLG----------------------------PEAKS-LLSGLLKKDPKQRLGGGSEDAKEIMQHRFF--------------
----FEIGRPLGKGKFGNV---YLARE---K-------QSKFILALKVLFKA--QLEKA---GV--E-HQLRR--EVEIQSHL--R---HPNILRLYGYFH--D------ATR--VY--LILEYAPLG--TVYRELQ----KLS-----------------KFDEQRTATYITELANALSYCHS-KRVIHRDIKPENLLLG-SAGELKIADFGWSV------HAPSSRR--TT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN----TYQETY-KRISRVEFTFPDFVT----------------------------EGARD-LISRLLKHNPSQRPM-----LREVLEHPWI--------------
---L-RLVRKLGSGQFGEV---WMGYY---K--------NNMKVAIKTLK-E--G-TM----SP--E-AFL-G--EANVMKAL--Q---HERLVRLYAVVT---------KEP--IY--IVTEYMARG--CLLDFLK-----TD--------------EGSRLSLPRLIDMSAQIAEGMAYIER-MNSIHRDLRAANILVS-EALCCKIADFGLARII-------DSEY--TAQEGAKFPIKWTAPEAIH-FGVFTIKADVWSFGVLLMEVVTYGRVP---------------YPGM-SNPEVIRNL-ERGYRMPRPDTCP------------------------------PELYRGVIAECWRSRPEERPT-----FEFLQSV--L--------------
----YTKIEKIGEGTYGVV---YKGRH---K-------TTGQVVAMKKIRLE--S-EEE---GV--P-STAIR--EISLLKEL--R---HPNIVSLQDVLM--Q------DSR--LY--LIFEFLSM---DLKKYLDS-IPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHS-RRVLHRDLKPQNLLID-DKGTIKLADFGLARAF----GIPIRVY--TH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPL---------------FHGD-SEIDQLFRI-FRALGTPNNEVWPEVESLQDYKNTFPKWKP--GSLASHVKNLDENGLD-LLSKMLIYDPAKRIS-----GKMALNHPYF--------------
---Y-EPVAEIGVGAYGTV---YKARD---P-------HSGHFVALKSVRVP--N-GGGGGGGL--P-ISTVR--EVALLRRL--EAFEHPNVVRLMDVCA--TSR-TDREIK--VT--LVFEHVDQ---DLRTYLDK--APPP-----------------GLPAETIKDLMRQFLRGLDFLHA-NCIVHRDLKPENILVT-SGGTVKLADFGLARI-----YSYQMAL--TP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPL---------------FCGN-SEADQLGKI-FDLIGLPPEDDWPRDVSLPRGAFPPRGPR----PVQSVVPEMEESGAQ-LLLEMLTFNPHKRIS-----AFRALQHSYL--------------
---W-DLVQTLGEGAYGEV---QLAVN---R-------VTEEAVAVKIVDMK--R-AVD---CP--E-NI-KK--EICINKML--N---HENVVKFYGHRR--E------GNI--QY--LFLEYCSGG--ELFDRIE----PDI-----------------GMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLLLD-ERDNLKISDFGLATVFR--YNNRERLL--NK---MCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLA-GELP---------------WDQP---SDSCQEY-SDWKEKKTYLNPWKKI--D------------------------SAPLA-LLHKILVENPSARIT-----IPDIKKDRW-Y-------------
---L-VLGKPLGEGCFGQV---VLAEA---IGLDKDKPNRVTKVAVKMLK-S--D-AT----EKDLS-DLI-S--EMEMMKMIG-K---HKNIINLLGACT--Q------DGP--LY--VIVEYASKG--NLREYLQ-----ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLAS-KKCIHRDLAARNVLVT-EDNVMKIADFGLARDI--H-H--IDYY--KKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSP---------------YPGV-PVEELFKLL-KEGHRMDKPSNCT------------------------------NELYM-MMRDCWHAVPSQRPT-----FKQLVEDL----------------
----LQLIKRLGNGQFGEV---WMGTW---N--------GNTKVAIKTLK-P--G-TM----SP--E-SFL-E--EAQIMKKL--K---HDKLVQLYAVVS---------EEP--IY--IVTEYMNKG--SLLDFLK-----DG--------------EGRALKLPNLVDMAAQVAAGMAYIER-MNYIHRDLRSANILVG-NGLICKIADFGLARLI----E--DNEY--TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELVTKGRVP---------------YPGM-NNREVLEQV-ERGYRMPCPQDCP------------------------------ISLHE-LMIHCWKKDPEERPT-----FEYLQSFL----------------
----YTDTKVIGNGSFGVV---YQAKL---C-------DSGELVAIKKVLQD--K-RFK---NR-----------ELQIMRKL--D---HCNIVRLRYFFY--SSG--EKKDE--VYLNLVLDYVPETVYRVA---RHYSRAKQ-----------------TLPVIYVKLYMYQLFRSLAYIHS-FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-----LVRGEPN--VS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPI---------------FPGD-SGVDQLVEI-IKVLGTPTREQIREMNPNYTEFKFPQIKAH--PWTKVFRPRTPPEAIA-LCSRLLEYTPTARLT-----PLEACAHSFF--------------
----LKLEKKLGAGQFGEV---WMATY---N--------KHTKVAVKTMK-P--G-SM----SV--E-AFL-A--EANVMKTL--Q---HDKLVKLHAVVT---------KEP--IY--IITEFMAKG--SLLDFLK-----SD--------------EGSKQPLPKLIDFSAQIAEGMAFIEQ-RNYIHRDLRAANILVS-ASLVCKIADFGLARVI----E--DNEY--TAREGAKFPIKWTAPEAIN-FGSFTIKSDVWSFGILLMEIVTYGRIP---------------YPGM-SNPEVIRAL-ERGYRMPRPENCP------------------------------EELYN-IMMRCWKNRPEERPT-----FEYIQSV--L--------------
-VGG----NKMGEGGFGVV---YKGYV---N-------NTT--VAVKKLAAM--V-DIT---TE--ELKQQFD-QEIKVMAKC--Q---HENLVELLGFSS--D------GDD--LC--LVYVYMPNG--SLLDRLSC-LDGTP-----------------PLSWHMRCKIAQGAANGINFLHE-NHHIHRDIKSANILLD-EAFTAKISDFGLARASE--KFAQTVMT--SR---IVGTTAYMAPEALR--GEITPKSDIYSFGVVLLEIIT-GLPA---------------VDEH-REPQLLLDI-KEEIEDEEKTIEDYIDKKMNDAD----------------STSVEAMYS-VASQCLHEKKNKRPD-----IKKVQQ----LLQ-----------
---L-KRIRDLGEGHFGKV---ELCRY---DP---EGDNTGEQVAVKSLK-P--E-SG----GNHIA-DLK-K--EIEILRNL--Y---HENIVKYKGICT-ED-------GGNGIK--LIMEFLPSG--SLKEYLP-----KN---------------KNKINLKQQLKYAVQICKGMDYLGS-RQYVHRDLAARNVLVE-SEHQVKIGDFGLTKAI-ET-D--KEYY--TVKDDRDSPVFWYAPECLM-QSKFYIASDVWSFGVTLHELLTYCDSDSSPMALF-LKMIGPTHGQM-TVTRLVNTL-KEGKRLPCPPNCP------------------------------DEVYQ-LMRKCWEFQPSNRTS-----FQNLIE---GF-------------
----LKFLQQLGKGNFGSV---EMCRY---DP---LQDNTGEVVAVKKLQ-H--S-TE-----EHLR-DFE-R--EIEILKSL--Q---HDNIVKYKGVCYSAG------RRN--LK--LIMEYLPYG--SLRDYLQ-----KH---------------KERIDHIKLLQYTSQICKGMEYLGT-KRYIHRDLATRNILVE-NENRVKIGDFGLTKVL-PQ-D--KEYY--KVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELL-KNNGRLPRPDGCP------------------------------DEIYM-IMTECWNNNVNQRPS-----FRDLA----LRV------------
---L-KYISQLGKGNFGSV---ELCRY---DP---LGDNTGALVAVKQLQ-H--S-GP----DQ-QR-DFQ-R--EIQILKAL--H---SDFIVKYRGVSYGPG------RQS--LR--LVMEYLPSG--CLRDFLQ-----RH---------------RARLDASRLLLYSSQICKGMEYLGS-RRCVHRDLAARNILVE-SEAHVKIADFGLAKLL-PL-D--KDYY--VVREPGQSPIFWYAPESLS-DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELL-EEGQRLPAPPACP------------------------------AEVHE-LMKLCWAPSPQDRPS-----FSALGP---QL-------------
----LKLVERLGAGQFGEV---WMGYY---N--------GHTKVAVKSLK-Q--G-SM----SP--D-AFL-A--EANLMKQL--Q---HQRLVRLYAVVT---------QEP--IY--IITEYMENG--SLVDFLK-----TP--------------SGIKLTINKLLDMAAQIAEGMAFIEE-RNYIHRDLRAANILVS-DTLSCKIADFGLARLI----E--DNEY--TAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNL-ERGYRMVRPDNCP------------------------------EELYQ-LMRLCWKERPEDRPT-----FDYLRSV--L--------------
----IKLVKRLGAGQFGEV---WMGYY---N--------NSTKVAVKTLK-P--G-TM----SV--Q-AFL-E--EANLMKTL--Q---HDKLVRLYAVVT--R------EEP--IY--IITEYMAKG--SLLDFLK-----SD--------------EGGKVLLPKLIDFSAQIAEGMAYIER-KNYIHRDLRAANVLVS-ESLMCKIADFGLARVI----E--DNEY--TAREGAKFPIKWTAPEAIN-FGCFTIKSDVWSFGILLYEIVTYGKIP---------------YPGR-TNADVMTAL-SQGYRMPRVENCP------------------------------DELYD-IMKMCWKEKAEERPT-----FDYLQSV--L--------------
----YQNLSPVGSGAYGSV---CAAFD---T-------KTGLRVAVKKLSRP--F-QSI---IH--A-KRTYR--ELRLLKHM--K---HENVIGLLDVFT--PARSLEEFND--VY--LVTHLMGA---DLNNIVK-----CQ-----------------KLTDDHVQFLIYQILRGLKYIHS-ADIIHRDLKPSNLAVN-EDCELKILDFGLAR-------HTDDEM--TG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTL---------------FPGT-DHIDQLKLI-LRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVD-LLEKMLVLDSDKRIT-----AAQALAHAYF--------------
----VHFNEVIGRGHFGCV---YHGTL---L----DNDGKKIHCAVKSLN-R--I-TD----IGEVS-QFL-T--EGIIMKDF--S---HPNVLSLLGICL-RS------EGS--PL--VVLPYMKHG--DLRNFIR-----NE---------------THNPTVKDLIGFGLQVAKGMKYLAS-KKFVHRDLAARNCMLD-EKFTVKVADFGLARDM--Y-D--KEYYSVHNKTGAKLPVKWMALESLQ-TQKFTTKSDVWSFGVLLWELMTRGAPP---------------YPDV-NTFDITVYL-LQGRRLLQPEYCP------------------------------DPLYE-VMLKCWHPKAEMRPS-----FSELVSR--I--------------
--YV--RGRFLGKGGFAKC---FEISD---A-------DTKEVFAGKIVPKS--L-LLK---PH--Q-REKMS-MEISIHRSL--A---HQHVVGFHGFFE--D------NDF--VF--VVLELCRRR--SLLELHK----RRK-----------------ALTEPEARYYLRQIVLGCQYLHR-NRVIHRDLKLGNLFLN-EDLEVKIGDFGLATKV----EYDGERK--KT---LCGTPNYIAPEVLS-KKGHSFEVDVWSIGCIMYTLLV-GKPP---------------FETS----CLKETY-LRIKKNEYSIPKHIN----------------------------PVAAS-LIQKMLQTDPTARPT-----INELLNDEFF--------------
---F-NFLMVLGKGSFGKV---MLADR---K-------GTEELYAIKILKKD--V-VIQ---DD--D-VECTM-VEKRVLALL-DK---PPFLTQLHSCFQ--T------VDR--LY--FVMEYVNGG--DLMYHIQ----QVG-----------------KFKEPQAVFYAAEISIGLFFLHK-RGIIYRDLKLDNVMLD-SEGHIKIADFGMCKEH----MMDGVTT--RT---FCGTPDYIAPEIIA-YQPYGKSVDWWAYGVLLYEMLA-GQPP---------------FDGE----DEDELF-QSIMEHNVSYPKSLS----------------------------KEAVS-VCKGLMTKHPAKRLG-----C---------GPEGERDVREHAFF
---F-NFLMVLGKGSFGKV---MLSER---K-------GTDELYAVKILKKD--V-VIQ---DD--D-VECTM-VEKRVLALP-GK---PPFLTQLHSCFQ--T------MDR--LY--FVMEYVNGG--DLMYHIQ----QVG-----------------RFKEPHAVFYAAEIAIGLFFLQS-KGIIYRDLKLDNVMLD-SEGHIKIADFGMCKEN----IWDGVTT--KT---FCGTPDYIAPEIIA-YQPYGKSVDWWAFGVLLYEMLA-GQAP---------------FEGE----DEDELF-QSIMEHNVAYPKSMS----------------------------KEAVA-ICKGLMTKHPGKRLG-----C---------GPEGERDIKEHAFF
----FELLKVLGQGSFGKVFLVRKVTR---P-------DSGHLYAMKVLKKA--T-LKV---RD--R-VRTKM--ERDILADV--N---HPFVVKLHYAFQ--T------EGK--LY--LILDFLRGG--DLFTRLS----KEV-----------------MFTEEDVKFYLAELALGLDHLHS-LGIIYRDLKPENILLD-EEGHIKLTDFGLSKEA----IDHEKKA--YS---FCGTVEYMAPEVVN-RQGHSHSADWWSYGVLMFEMLT-GSLP---------------FQGK----DRKETM-TLILKAKLGMPQFLS----------------------------TEAQS-LLRALFKRNPANRLGSGPDGAEEIKRHV--FY------------
----FELLRVLGKGGYGKV---FQVRKVTGA-------NTGKIFAMKVLKKA--M-IVR---NA--K-DTAHTKAERNILEEV--K---HPFIVDLIYAFQ--T------GGK--LY--LILEYLSGG--ELFMQLE----REG-----------------IFMEDTACFYLAEISMALGHLHQ-KGIIYRDLKPENIMLN-HQGHVKLTDFGLCKES----IHDGTVT--HT---FCGTIEYMAPEILM-RSGHNRAVDWWSLGALMYDMLT-GAPP---------------FTGE----NRKKTI-DKILKCKLNLPPYLT----------------------------QEARD-LLKKLLKRNAASRLGAGPGDAGEVQAHPFF--------------
---L-RLEVKLGQGCFGEV---WMGTW---N--------GTTRVAIKTLK-P--G-TM----SP--E-AFL-Q--EAQVMKKL--R---HEKLVQLYAVVS---------EEP--IY--IVTEYMSKG--SLLDFLK-----GE--------------TGKYLRLPQLVDMAAQIASGMAYVER-MNYVHRDLRAANILVG-ENLVCKVADFGLARLI----E--DNEY--TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVP---------------YPGM-VNREVLDQV-ERGYRMPCPPECP------------------------------ESLHD-LMCQCWRKEPEERPT-----FEYLQAF--L--------------
---L-RLLEKLGDGSFGVV---RRGEW---D----APSGKTVSVAVKCLK-PDVL-SQ----PEAMD-DFI-R--EVNAMHSL--D---HRNLIRLYGVVL---------TPP--MK--MVTELAPLG--SLLDRLR-----KH---------------QGHFLLGTLSRYAVQVAEGMGYLES-KRFIHRDLAARNLLLA-TRDLVKIGDFGLMRAL-PQ-N--DDHY--VMQEHRKVPFAWCAPESLK-TRTFSHASDTWMFGVTLWEMFTYGQEP---------------WIGL-NGSQILHKIDKEGERLPRPEDCP------------------------------QDIYN-VMVQCWAHKPEDRPT-----FVALRDF--L--------------
---L-RLEVKLGQGCFGEV---WMGTW---N--------GTTKVAIKTLK-P--G-TM----MP--E-AFL-Q--EAQIMKKL--R---HDKLVPLYAVVS---------EEP--IY--IVTEFMSKG--SLLDFLK-----EG--------------DGKYLKLPQLVDMAAQIADGMAYIER-MNYIHRDLRAANILVG-ENLVCKIADFGLARLI----E--DNEY--TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILQTELVTKGRVP---------------YPGM-VNREVLEQV-ERGYRMPCPQGCP------------------------------ESLHE-LMNLCWKKDPDERPT-----FEYIQSFL----------------
LIAD----IELGCGNFGSV---RQGVY---R-----MRKKQIDVAIKVLK-Q--G-TE----KADTE-EMM-R--EAQIMHQL--D---NPYIVRLIGVCQ---------AEA--LM--LVMEMAGGG--PLHKFLV-----GK---------------REEIPVSNVAELLHQVSMGMKYLEE-KNFVHRDLAARNVLLV-NRHYAKISDFGLSKAL-GA-D--DSYY--TARSAGKWPLKWYAPECIN-FRKFSSRSDVWSYGVTMWEALSYGQKP---------------YKKM-KGPEVMAFI-EQGKRMECPPECP------------------------------PELYA-LMSDCWIYKWEDRPD-----FLTVEQR--M--------------
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