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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
TK ABL1 261
Other AURKA 133
CMGC CDC2 4
CMGC CDK4 6
CMGC GSK3A 119
CMGC GSK3B 56
TK ITK 363
CMGC MAPK10 64
CAMK MARK1 60
TK MET 1078
CAMK PIM2 132
Other PLK1 53
TK SRC 270
--FQKVEKIGEGTYGVVYKARNK---LTGEVVALKKIRLDT-ETE---GV--PSTAIR----EISLLKELN----HPNIVKLLDVIH-T------ENKLY--LVFEF-LHQ---DLKKFMDA--SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF-GVPVRTY--TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
--ITMKHKLGGGQYGEVYEGVWK---KYSLTVAVKTLK-ED-TM----EV--EEFL-K----EAAVMKEIK----HPNLVQLLGVCT-R------EPPFY--IITEF-MTYG--NLLDYLR-----ECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLVKVADFGLSRLM-T--GDTY--TAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP-----------------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F
--FEIGRPLGKGKFGNVYLAREK---QSKFILALKVLFKAQLEKA---GV--EHQLRR----EVEIQSHLR----HPNILRLYGYFH-D------ATRVY--LILEY-APLG--TVYRELQ----KLS---KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGELKIADFGWSV---HAPSSRR--TT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI
--YTKIEKIGEGTYGVVYKGRHK---TTGQVVAMKKIRLES-EEE---GV--PSTAIR----EISLLKELR----HPNIVSLQDVLM-Q------DSRLY--LIFEF-LSM---DLKKYLDS-IPPGQ---YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAF-GIPIRVY--TH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
-Y-EPVAEIGVGAYGTVYKARDP---HSGHFVALKSVRVPN-GGGGGGGL--PISTVR----EVALLRRLEA-FEHPNVVRLMDVCA-TSR-TDREIKVT--LVFEH-VDQ---DLRTYLDK--APPP---GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARI--YSYQMAL--TP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR---------------PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL
--YTDIKVIGNGSFGVVYQARLA---ETRELVAIKKVLQDK-RFK---NR------------ELQIMRKLD----HCNIVRLRYFFY-SSG--EKKDELYLNLVLEY-VPETVYRVARHFT---KAKL---TIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQ--LVRGEPN--VS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF
--YTDTKVIGNGSFGVVYQAKLC---DSGELVAIKKVLQDK-RFK---NR------------ELQIMRKLD----HCNIVRLRYFFY-SSG--EKKDEVYLNLVLDY-VPETVYRVA---RHYSRAKQ---TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ--LVRGEPN--VS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF
--LTFVQEIGSGQFGLVHLGYWL----NKDKVAIKTIR-EG-AM----SE--EDFI-E----EAEVMMKLS----HPKLVQLYGVCL-E------QAPIC--LVFEF-MEHG--CLSDYLR-----TQ-RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVG-ENQVIKVSDFGMTRFV-L--DDQY--TSSTGTKFPVKWASPEVFS-FSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLAS-----------------------------------------THVYQIMNHCWKERPEDRPAFSRLLRQL--
--YQNLKPIGSGAQGIVCAAYDA---VLDRNVAIKKLSRPF-QNQ---TH--AKRAYR----ELVLMKCVN----HKNIISLLNVFT-PQKTLEEFQDVY--LVMEL-MDA---NLCQVIQ------M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART--AGTSFMM--TP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI
--YRLQKTIGKGNFAKVKLARHV---LTGREVAVKIIDKTQ-LNP---TS--LQKLFR----EVRIMKILN----HPNIVKLFEVIE-T------EKTLY--LVMEY-ASGG--EVFDYLV----AHG---RMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLD-GDMNIKIADFGFSNE--FTVGNKL--DT---FCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVS-GSLPFDGQ---NLKELRERVLRGKYRIPFYMS---------------------------------------TDCENLLKKLLVLNPIKRGSLEQIMKDRWM
--VHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN-RI-TD----IGEVSQFL-T----EGIIMKDFS----HPNVLSLLGICLRS------EGSPL--VVLPY-MKHG--DLRNFIR-----NE-THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLD-EKFTVKVADFGLARDMYD--KEYYSVHNKTGAKLPVKWMALESLQ-TQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCP-----------------------------------------DPLYEVMLKCWHPKAEMRPSFSELVSR--I
--YRLGPLLGKGGFGTVFAGHRL---TDRLQVAIKVIPRNR-VLG---WS--PLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFE-T------QEGFM--LVLERPLPAQ--DLFDYIT----EKG---PLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGA---LLHDEPY--TD---FDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVC-GDIPFERD---------QEILEAELHFPAHVS---------------------------------------PDCCALIRRCLAPKPSSRPSLEEILLDPWM
YV--RGRFLGKGGFAKCFEISDA---DTKEVFAGKIVPKSL-LLK---PH--QREKMS---MEISIHRSLA----HQHVVGFHGFFE-D------NDFVF--VVLEL-CRRR--SLLELHK----RRK---ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN-EDLEVKIGDFGLATKV-EYDGERK--KT---LCGTPNYIAPEVLS-KKGHSFEVDVWSIGCIMYTLLV-GKPPFETS---CLKETYLRIKKNEYSIPKHIN---------------------------------------PVAASLIQKMLQTDPTARPTINELLNDEFF
-L-RLEVKLGQGCFGEVWMGTWN----GTTRVAIKTLK-PG-TM----SP--EAFL-Q----EAQVMKKLR----HEKLVQLYAVVS--------EEPIY--IVTEY-MSKG--SLLDFLK-----GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVCKVADFGLARLI-E--DNEY--TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP-----------------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L
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