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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK CHEK1 203
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK5 4
CAMK CHEK2 220
CMGC CSNK2A1 39
CAMK DAPK3 13
CMGC GSK3B 56
STE MAP3K5 677
CMGC MAPK1 13
AGC PDPK1 82
CAMK PIM1 38
AGC PRKACA 44
AGC PRKCA 339
AGC PRKCB 342
--W-DLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPEN-I-KK------EICINKML-NHEN--VVKFYGHRRE-----GNIQY--LFLEYCSGG--ELFDRIE----PDIGM--PEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL----KISDFGLATVFR-YNNRERLLNKMCGTLPYVAPELLK--RREFHAEPVDVWSCGIVLTAMLA-GELPWD-QP--SDSCQEYSDWKEKKTYLNPWKKI--D------------------------------SAPLALLHKILVENPSARIT-----IPDIKKDRW-Y-------------
---YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPS-TAIR------EISLLKEL-RHPN--IVSLQDVLMQ-----DSRLY--LIFEFLSM---DLKKYLDS-IPPGQYM--DSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI----KLADFGLARAF---GIPIRVYTHEVVTLWYRSPEVLL--GSARYSTPVDIWSIGTIFAELAT-KKPLFH-GDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP--------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYF--------------
---FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPS-TAIR------EISLLKEL-NHPN--IVKLLDVIHT-----ENKLY--LVFEFLHQ---DLKKFMDA--SALTGI--PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF---GVPVRTYTHEVVTLWYRAPEILL--GCKYYSTAVDIWSLGCIFAEMVT-RRALFP-GDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF--------------
---YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPS-SALR------EICLLKEL-KHKN--IVRLHDVLHS-----DKKLT--LVFEFCDQ---DLKKYFD---SCNGDL--DPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL----KLADFGLARAF---GIPVRCYSAEVVTLWYRPPDVLF--GAKLYSTSIDMWSAGCIFAELANAGRPLFP-GNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT--------TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYF--------------
-YI--MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAR-EADPALNVETEIEILKKL-NHPC--IIKIKNFF-D-----AEDYY--IVLELMEGG--ELFDKVV----GNKRL--KEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS-SQEEDC-LIKITDFGHSKI----LGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFS-EH--RTQVSLKDQITSGKYNFIPEVWAEVS------------------------------EKALDLVKKLLVVDPKARFT-----TEEALRHPWL--------------
---YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR------------EIKILENLRGGPN--IITLADIVKDP---VSRTPA--LVFEHVNNT--DFKQLY-------QTL--TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL----RLIDWGLAEF----YHPGQEYNVRVASRYFKGPELLV--DYQMYDYSLDMWSLGCMLASMIF-RKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----AREAMEHPYF--------------
---YEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRG-VSREEI--EREVNILREI-RHPN--IITLHDIFEN-----KTDVV--LILELVSGG--ELFDFLA----EKESL--TEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLL-DKNVPNPRIKLIDFGIAHK----IEAGNEFKNIFGTPEFVAPEIVN---YEPLGLEADMWSIGVITYILLS-GASPFL-GE---TKQETLTNISAVNYDFDEEYFSNTS------------------------------ELAKDFIRRLLVKDPKRRMT-----IAQSLEHSWI--------------
---YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR-------------ELQIMRKL-DHCN--IVRLRYFFYSSG-EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTL--PVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL----KLCDFGSAKQ----LVRGEPNVSYICSRYYRAPELIF--GATDYTSSIDVWSAGCVLAELLL-GQPIFP-GDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF--------------
DRV-----VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPL-H--E------EIALHKHL-KHKN--IVQYLGSFSE-----NGFIK--IFMEQVPGG--SLSALLR---SKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVL----KISDFGTSKRL---AGINPCTETFTGTLQYMAPEIID-KGPRGYGKAADIWSLGCTIIEMAT-GKPPFY-EL--GEPQAAMFKVGMFKVHPEIPESMS--------------------------------AEAKAFILKCFEPDPDKRAC-----ANDLLVDEF-L-------------
---YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQR-T-LR------EIKILLRF-RHEN--IIGINDIIRAPTIEQMKDVY--IVQDLMET---DLYKLLK-----TQHL--SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDL----KICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIML--NSKGYTKSIDIWSVGCILAEMLS-NRPIFP-GKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIE-----VEQALAHPYL--------------
--F-KFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTR------ERDVMSRL-DHPF--FVKLYFTFQD-----DEKLY--FGLSYAKNG--ELLKYIR----KIGSF--DETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHI----QITDFGTAKVLS-PESKQARANSFVGTAQYVSPELLT---EKSACKSSDLWALGCIIYQLVA-GLPPFR-AG---NEYLIFQKIIKLEYDFPEKFF----------------------------------PKARDLVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF---
---YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGEL-PNGTRV--PMEVVLLKKV-SSGFSGVIRLLDWFER-----PDSFV--LILERPEPV-QDLFDFIT----ERGAL--QEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL----KLIDFGSGA-----LLKDTVYTDFDGTRVYSPPEWIR--YHRYHGRSAAVWSLGILLYDMVC-GDIPFE-HD---------EEIIRGQVFFRQRVS----------------------------------SECQHLIRWCLALRPSDRPT-----FEEIQNHPWM--------------
--F-ERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQI-EHTL-----NEKRILQAV-NFPF--LVKLEFSFKD-----NSNLY--MVMEYVPGG--EMFSHLR----RIGRF--SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID-QQGYI----QVTDFGFAK------RVKGRTWTLCGTPEYLAPEIIL---SKGYNKAVDWWALGVLIYEMAA-GYPPFF-AD---QPIQIYEKIVSGKVRFPSHFS----------------------------------SDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF--------------
--F-NFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDV-ECTM-----VEKRVLALLDKPPF--LTQLHSCFQT-----VDRLY--FVMEYVNGG--DLMYHIQ----QVGKF--KEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLD-SEGHI----KIADFGMCKEH---MMDGVTTRTFCGTPDYIAPEIIA---YQPYGKSVDWWAYGVLLYEMLA-GQPPFD-GE---DEDELFQSIMEHNVSYPKSLS----------------------------------KEAVSVCKGLMTKHPAKRLG-----C---------GPEGERDVREHAFF
--F-NFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDV-ECTM-----VEKRVLALPGKPPF--LTQLHSCFQT-----MDRLY--FVMEYVNGG--DLMYHIQ----QVGRF--KEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLD-SEGHI----KIADFGMCKEN---IWDGVTTKTFCGTPDYIAPEIIA---YQPYGKSVDWWAFGVLLYEMLA-GQAPFE-GE---DEDELFQSIMEHNVAYPKSMS----------------------------------KEAVAICKGLMTKHPGKRLG-----C---------GPEGERDIKEHAFF
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