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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK CHEK1 203
Other AURKA 133
Other CAMKK2 165
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK4 6
CMGC CDK5 4
CMGC CDK9 2.7.11.23
CAMK CHEK2 220
Other CHUK 15
TK FYN 271
TKL IRAK4 186
CMGC MAPK1 13
CMGC MAPK10 64
CMGC MAPK14 24
TK NTRK2 538
TK NTRK3 538
STE PAK4 321
CMGC PCTK1 165
CAMK PIM1 38
CAMK PIM2 132
Other PLK1 53
Other PLK3 62
AGC PRKCA 339
AGC PRKCD 349
AGC RPS6KA1 62
AGC RPS6KA2 59
TK SRC 270
CAMK STK33 116
---W-DLVQTLGEGAYGEV---QLAVNR-----VTEE---AVAVKIVDMKR-AVD---CP-E-NI-KK-------------------------EICINKML-N----HEN--VVKFYGHRRE--------GNIQYLFLEY-CSGG-ELFDRIE---PDI-----------------GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL---------KISDFGLATVFR---YNNRERLL--------------NK---MCGTLPYVAPELLK--RREF--HAEPVDVWSCGIVLTAMLA-GELPWDQP-------------SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------SAPLALLHKILVENPSARIT-----IPDIKKDRW-Y-------------
----FEIGRPLGKGKFGNV---YLAREK-----QSKF---ILALKVLFKAQLEKA---GV-E-HQLRR-------------------------EVEIQSHL-R----HPN--ILRLYGYFHD--------ATRVYLILEY-APLG-TVYRELQ---KLS-----------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL---------KIADFGWSV-------HAPSSRR--------------TT---LCGTLDYLPPEMIE---GRM--HDEKVDLWSLGVLCYEFLV-GKPPFEAN--------------TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI--------------
----YTLKDEIGKGSYGVV---KLAYNE-----NDNT---YYAMKVLSKKK-LIR---QA-G-FPR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL-D----HPN--VVKLVEVLDDP------NEDHLYMVFEL-VNQG-PVMEVPT----LK-----------------PLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG-EDGHI---------KIADFGVSNEF-----KGSDALL--------------SN---TVGTPAFMAPESLS--ETRKIFSGKALDVWAMGVTLYCFVF-GQCPFMDE--------------RIMCLHSKIKSQALEFPDQPDIA-------------------------------------EDLKDLITRMLDKNPESRIV-----VPEIKLHPWV--------------
----YTKIEKIGEGTYGVV---YKGRHK-----TTGQ---VVAMKKIRLES-EEE---GV-P-STAIR-------------------------EISLLKEL-R----HPN--IVSLQDVLMQ--------DSRLYLIFEF-LSM--DLKKYLDSIPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI---------KLADFGLARAF-----GIPIRVY--------------TH---EVVTLWYRSPEVLL--GSAR--YSTPVDIWSIGTIFAELAT-KKPLFHGD-----------SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYF--------------
----FQKVEKIGEGTYGVV---YKARNK-----LTGE---VVALKKIRLDT-ETE---GV-P-STAIR-------------------------EISLLKEL-N----HPN--IVKLLDVIHT--------ENKLYLVFEF-LHQ--DLKKFMDA-SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI---------KLADFGLARAF-----GVPVRTY--------------TH---EVVTLWYRAPEILL--GCKY--YSTAVDIWSLGCIFAEMVT-RRALFPGD-----------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF--------------
----FQKVEKIGEGTYGVV---YKAKNR-----ETGQ---LVALKKIRLDL-EME---GV-P-STAIR-------------------------EISLLKEL-K----HPN--IVRLLDVVHN--------ERKLYLVFEF-LSQ--DLKKYMDS-TPGS-----------------ELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLIN-ELGAI---------KLADFGLARAF-----GVPLRTY--------------TH---EVVTLWYRAPEILL--GSKF--YTTAVDIWSIGCIFAEMVT-RKALFPGD-----------SEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR-------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRIT-----AKTALAHPYF--------------
---Y-EPVAEIGVGAYGTV---YKARDP-----HSGH---FVALKSVRVPN-GGGGGGGL-P-ISTVR-------------------------EVALLRRL-EA-FEHPN--VVRLMDVCATSR---TDREIKVTLVFEH-VDQ--DLRTYLDK-APPP-----------------GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTV---------KLADFGLARI------YSYQMAL--------------TP---VVVTLWYRAPEVLL---QST--YATPVDMWSVGCIFAEMFR-RKPLFCGN-----------SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR---------------PVQSVVPEMEESGAQLLLEMLTFNPHKRIS-----AFRALQHSYL--------------
----YEKLEKIGEGTYGTV---FKAKNR-----ETHE---IVALKRVRLDD-DDE---GV-P-SSALR-------------------------EICLLKEL-K----HKN--IVRLHDVLHS--------DKKLTLVFEF-CDQ--DLKKYFD--SCNG-----------------DLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL---------KLADFGLARAF-----GIPVRCY--------------SA---EVVTLWYRPPDVLF--GAKL--YSTSIDMWSAGCIFAELANAGRPLFPGN-----------DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYF--------------
----YEKLAKIGQGTFGEV---FKARHR-----KTGQ---KVALKKVLMEN-EKE---GF-P-ITALR-------------------------EIKILQLL-K----HEN--VVNLIEICRTKASPYNRCKGSIYLVFDF-CEH--DLAGLLS--NVLV-----------------KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVL---------KLADFGLARAFSL-AKNSQPNRY--------------TN---RVVTLWYRPPELLL--GERD--YGPPIDLWGAGCIMAEMWT-RSPIMQGN-----------TEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK----------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-----SDDALNHDFF--------------
--YI--MSKTLGSGACGEV---KLAFER-----KTCK---KVAIKIISKRK-FAI---GS-A-READPALN-------------------VETEIEILKKL-N----HPC--IIKIKNFF-D--------AEDYYIVLEL-MEGG-ELFDKVV---GNK-----------------RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS-SQEEDC------LIKITDFGHSKI------LGETSLM--------------RT---LCGTPTYLAPEVLVSVGTAG--YNRAVDCWSLGVILFICLS-GYPPFSEH-------------RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------EKALDLVKKLLVVDPKARFT-----TEEALRHPWL--------------
---W-EMRERLGTGGFGNV---CLYQHR-----ELDL---KIAIKSCRLEL-STK---NR-E-R-WCH-------------------------EIQIMKKL-N----HAN--VVKACDVPEELN---ILIHDVPLLAMEY-CSGG-DLRKLLNKPENCC-----------------GLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQ-DVGGKI------IHKIIDLGYAKD------VDQGSLC--------------TS---FVGTLQYLAPELFE---NKP--YTATVDYWSFGTMVFECIA-GYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSHLPQPNSLCS-----------------------------LVVEPMENWLQLMLNWDPQQRG----------------GPVDLTLKQ-----
----LQLIKRLGNGQFGEV---WMGTWN------GNT---KVAIKTLK-PG-TM----SP-E-SFL-E-------------------------EAQIMKKL-K----HDK--LVQLYAVVS---------EEPIYIVTEY-MNKG-SLLDFLK----DG--------------EGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVG-NGLIC---------KIADFGLARLI-----E--DNEY--------------TARQGAKFPIKWTAPEAAL---YGR--FTIKSDVWSFGILLTELVTKGRVPYPGM-----------NNREVLEQVERGYRMPCPQDCP-----------------------------------------ISLHELMIHCWKKDPEERPT-----FEYLQSFL----------------
-VGG----NKMGEGGFGVV---YKGYVN-----NTT-----VAVKKLAAMV-DIT---TE-ELKQQFD------------------------QEIKVMAKC-Q----HEN--LVELLGFSSD--------GDDLCLVYVY-MPNG-SLLDRLSCLDGTP-----------------PLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLD-EAFTA---------KISDFGLARASE---KFAQTVMT--------------SR---IVGTTAYMAPEALR----GE--ITPKSDIYSFGVVLLEIIT-GLPAVDEH-----------REPQLLLDIKEEIEDEEKTIEDYIDKKMNDAD---------------------------STSVEAMYSVASQCLHEKKNKRPD-----IKKVQQ----LLQ-----------
----YTNLSYIGEGAYGMV---CSAYDN-----VNKV---RVAIKKISPFE-HQT---YC-Q-RT-LR-------------------------EIKILLRF-R----HEN--IIGINDIIRAPT---IEQMKDVYIVQDL-MET--DLYKLLK----TQ-----------------HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDL---------KICDFGLARVAD--PDHDHTGFL--------------TE---YVATRWYRAPEIML--NSKG--YTKSIDIWSVGCILAEMLS-NRPIFPGK-----------HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN-----------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIE-----VEQALAHPYL--------------
----YQNLKPIGSGAQGIV---CAAYDA-----VLDR---NVAIKKLSRPF-QNQ---TH-A-KRAYR-------------------------ELVLMKCV-N----HKN--IISLLNVFTPQKT--LEEFQDVYLVMEL-MDA--NLCQVIQ-----M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL---------KILDFGLART------AGTSFMM--------------TP---YVVTRYYRAPEVIL---GMG--YKENVDIWSVGCIMGEMVR-HKILFPGR-----------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VDDALQHPYI--------------
----YQNLSPVGSGAYGSV---CAAFDT-----KTGL---RVAVKKLSRPF-QSI---IH-A-KRTYR-------------------------ELRLLKHM-K----HEN--VIGLLDVFTPARS--LEEFNDVYLVTHL-MGA--DLNNIVK----CQ-----------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCEL---------KILDFGLAR--------HTDDEM--------------TG---YVATRWYRAPEIML--NWMH--YNQTVDIWSVGCIMAELLT-GRTLFPGT-----------DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-----AAQALAHAYF--------------
---I-VLKRELGEGAFGKV---FLAECYNLCPEQDKI---LVAVKTLK-DA-SD----NARK-DFH-R-------------------------EAELLTNL-Q----HEH--IVKFYGVCVE--------GDPLIMVFEY-MKHG-DLNKFLR----AHGPDAV---LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVG-ENLLV---------KIGDFGMSRDV--Y--S--TDYY--------------RVGGHTMLPIRWMPPESIM---YRK--FTTESDVWSLGVVLWEIFTYGKQPWYQL-----------SNNEVIECITQGRVLQRPRTCP-----------------------------------------QEVYELMLGCWQREPHMRKN-----IKGIHTL--L--------------
---I-VLKRELGEGAFGKV---FLAECYNLSPTKDKM---LVAVKALK-DP-TL----AARK-DFQ-R-------------------------EAELLTNL-Q----HEH--IVKFYGVCGD--------GDPLIMVFEY-MKHG-DLNKFLR----AHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVG-ANLLV---------KIGDFGMSRDV--Y--S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM---YRK--FTTESDVWSFGVILWEIFTYGKQPWFQL-----------SNTEVIECITQGRVLERPRVCP-----------------------------------------KEVYDVMLGCWQREPQQRLN-----IKEIYKIL----------------
DNFI-----KIGEGSTGIV---CIATVR-----SSGK---LVAVKKMDLRK-QQR---RE-L---LFN-------------------------EVVIMRDY-Q----HEN--VVEMYNSYLV--------GDELWVVMEF-LEGG-ALTDIVT----HT-----------------RMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLT-HDGRV---------KLSDFGFCAQV-----SKEVPRR--------------KS---LVGTPYWMAPELIS---RLP--YGPEVDIWSLGIMVIEMVD-GEPPYFNE-----------PPLKAMKMIRDNLPPRLKNLHKVS---------------------------------------PSLKGFLDRLLVRDPAQRAT-----AAELLKHPFL--------------
---Y-IKLDKLGEGTYATV---YKGKSK-----LTDN---LVALKEIRLEH-EEG---AP-C--TAIR-------------------------EVSLLKDL-K----HAN--IVTLHDIIHT--------EKSLTLVFEY-LDK--DLKQYLD--DCGN-----------------IINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLIN-ERGEL---------KLADFGLARAK-----SIPTKTY--------------SN---EVVTLWYRPPDILL--GSTD--YSTQIDMWGVGCIFYEMAT-GRPLFPGS-----------TVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYR------------AEALLSHAPRLDSDGADLLTKLLQFEGRNRIS-----AEDAMKHPFF--------------
----YQVGPLLGSGGFGSV---YSGIRV-----SDNL---PVAIKHVEKDR-ISD---WG-E-LPNGTRV---------------------PMEVVLLKKV-S----SGFSGVIRLLDWFER--------PDSFVLILER-PEPVQDLFDFIT---ERG-----------------ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL---------KLIDFGSGA-------LLKDTVY--------------TD---FDGTRVYSPPEWIR--YHRY--HGRSAAVWSLGILLYDMVC-GDIPFEHD--------------------EEIIRGQVFFRQRVS---------------------------------------SECQHLIRWCLALRPSDRPT-----FEEIQNHPWM--------------
----YRLGPLLGKGGFGTV---FAGHRL-----TDRL---QVAIKVIPRNR-VLG---WS-P-LSDSVTC---------------------PLEVALLWKV-GAGGGHPG--VIRLLDWFET--------QEGFMLVLERPLPAQ-DLFDYIT---EKG-----------------PLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCA---------KLIDFGSGA-------LLHDEPY--------------TD---FDGTRVYSPPEWIS--RHQY--HALPATVWSLGILLYDMVC-GDIPFERD--------------------QEILEAELHFPAHVS---------------------------------------PDCCALIRRCLAPKPSSRPS-----LEEILLDPWM--------------
--YV--RGRFLGKGGFAKC---FEISDA-----DTKE---VFAGKIVPKSL-LLK---PH-Q-REKMS------------------------MEISIHRSL-A----HQH--VVGFHGFFED--------NDFVFVVLEL-CRRR-SLLELHK---RRK-----------------ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN-EDLEV---------KIGDFGLATKV-----EYDGERK--------------KT---LCGTPNYIAPEVLS---KKG--HSFEVDVWSIGCIMYTLLV-GKPPFETS--------------CLKETYLRIKKNEYSIPKHIN---------------------------------------PVAASLIQKMLQTDPTARPT-----INELLNDEFF--------------
--YL--KGRLLGKGGFARC---YEATDT-----ETGS---AYAVKVIPQSR-VAK---PH-Q-REKIL------------------------NEIELHRDL-Q----HRH--IVRFSHHFED--------ADNIYIFLEL-CSRK-SLAHIWK---ARH-----------------TLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFIT-ENMEL---------KVGDFGLAARL-----EPPEQRK--------------KT---ICGTPNYVAPEVLL---RQG--HGPEADVWSLGCVMYTLLC-GSPPFETA--------------DLKETYRCIKQVHYTLPASLS---------------------------------------LPARQLLAAILRASPRDRPS-----IDQILRHDFF--------------
---F-NFLMVLGKGSFGKV---MLADRK-----GTEE---LYAIKILKKDV-VIQ---DD-D-VECTM------------------------VEKRVLALLDK----PPF--LTQLHSCFQT--------VDRLYFVMEY-VNGG-DLMYHIQ---QVG-----------------KFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLD-SEGHI---------KIADFGMCKEH-----MMDGVTT--------------RT---FCGTPDYIAPEIIA---YQP--YGKSVDWWAYGVLLYEMLA-GQPPFDGE--------------DEDELFQSIMEHNVSYPKSLS---------------------------------------KEAVSVCKGLMTKHPAKRLG-----C---------GPEGERDVREHAFF
--FI--FHKVLGKGSFGKV---LLGELK-----GRGE---YFAIKALKKDV-VLI---DD-D-VECTM------------------------VEKRVLTLAAE----NPF--LTHLICTFQT--------KDHLFFVMEF-LNGG-DLMYHIQ---DKG-----------------RFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLD-RDGHI---------KIADFGMCKEN-----IFGESRA--------------ST---FCGTPDYIAPEILQ---GLK--YTFSVDWWSFGVLLYEMLI-GQSPFHGD--------------DEDELFESIRVDTPHYPRWIT---------------------------------------KESKDILEKLFEREPTKRLG----VTGNIKIHPFF--------------
----FELLKVLGQGSFGKVFLVRKVTRP-----DSGH---LYAMKVLKKAT-LKV---RD-R-VRTKM-------------------------ERDILADV-N----HPF--VVKLHYAFQT--------EGKLYLILDF-LRGG-DLFTRLS---KEV-----------------MFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLD-EEGHI---------KLTDFGLSKEA-----IDHEKKA--------------YS---FCGTVEYMAPEVVN---RQG--HSHSADWWSYGVLMFEMLT-GSLPFQGK--------------DRKETMTLILKAKLGMPQFLS---------------------------------------TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV--FY------------
----FELLKVLGQGSYGKV---FLVRKV-----KGSDAGQLYAMKVLKKAT-LKV---RD-R-VRSKM-------------------------ERDILAEV-N----HPF--IVKLHYAFQT--------EGKLYLILDF-LRGG-DLFTRLS---KEV-----------------MFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLD-EEGHI---------KITDFGLSKEA-----IDHDKRA--------------YS---FCGTIEYMAPEVVN---RRG--HTQSADWWSFGVLMFEMLT-GSLPFQGK--------------DRKETMALILKAKLGMPQFLS---------------------------------------GEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF--------------
---L-RLEVKLGQGCFGEV---WMGTWN------GTT---RVAIKTLK-PG-TM----SP-E-AFL-Q-------------------------EAQVMKKL-R----HEK--LVQLYAVVS---------EEPIYIVTEY-MSKG-SLLDFLK----GE--------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVC---------KVADFGLARLI-----E--DNEY--------------TARQGAKFPIKWTAPEAAL---YGR--FTIKSDVWSFGILLTELTTKGRVPYPGM-----------VNREVLDQVERGYRMPCPPECP-----------------------------------------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L--------------
----YTFGRILGKGSFGIV---IEATDK-----ETET---KWAIKKVNKEK-AGS---SA-V-KLLER-------------------------EVNILKSV-K----HEH--IIHLEQVFET--------PKKMYLVMEL-CEDG-ELKEILD---RKG-----------------HFSENETRWIIQSLASAIAYLHNNDIVHRDLKLENIMVK-SSLIDDNNEINLNIKVTDFGLAVKK----QSRSEAML--------------QA---TCGTPIYMAPEVIS---AHD--YSQQCDIWSIGVVMYMLLR-GEPPFLAS--------------SEEKLFELIRKGELHFENAVWNSIS-----------------------------------DCAKSVLKQLMKVDPAHRIT-----AKELLDNQWL--------------
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