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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK CHEK1 203
Other AURKA 133
Other AURKB 77
CMGC CDC2 4
CMGC CDK5 4
CAMK CHEK2 220
CMGC GSK3B 56
CMGC MAPK10 64
CMGC MAPK14 24
CAMK MKNK2 84
AGC PDPK1 82
CAMK PIM1 38
AGC PRKG2 453
AGC ROCK2 92
---W-DLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKR-AVDCPEN-I-KK------EICINKML-NHEN--VVKFYGHRRE------GNIQY--LFLEYCSGG--ELFDRIE----PDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL---KISDFGLATVFR-----YNNRERLLNKMCGTLPYVAPELLK----RREFHAEPVDVWSCGIVLTAMLA-GELPWDQP--------------SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------SAPLALLHKILVENPSA--RIT-----IPDIKKDRW-Y----------
----FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEH-QLRR------EVEIQSHL-RHPN--ILRLYGYFHD------ATRVY--LILEYAPLG--TVYRELQ----KLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL---KIADFGWSV---------HAPSSRRTTLCGTLDYLPPEMIE-----GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---------------TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQ--RPM-----LREVLEHPWI-----------
----FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQ-IEKEGVE-HQLR-----REIEIQAHL-HHPN--ILRLYNYFYD------RRRIY--LILEYAPRG--ELYKELQ----KSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGEL---KIADFGWSV---------HAPSLRRKTMCGTLDYLPPEMIE-----GRMHNEKVDLWCIGVLCYELLV-GNPPFESA---------------SHNETYRRIVKVDLKFPASVP---------------------------------------MGAQDLISKLLRHNPSE--RLP-----LAQVSAHPWV-----------
----YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES-EEEGVPS-TAIR------EISLLKEL-RHPN--IVSLQDVLMQ------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI---KLADFGLARAF-------GIPIRVYTHEVVTLWYRSPEVLL----GSARYSTPVDIWSIGTIFAELAT-KKPLFHGD------------SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAK--RIS-----GKMALNHPYF-----------
----YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDD-DDEGVPS-SALR------EICLLKEL-KHKN--IVRLHDVLHS------DKKLT--LVFEFCDQ---DLKKYFD---SCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL---KLADFGLARAF-------GIPVRCYSAEVVTLWYRPPDVLF----GAKLYSTSIDMWSAGCIFAELANAGRPLFPGN------------DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-------------TSLVNVVPKLNATGRDLLQNLLKCNPVQ--RIS-----AEEALQHPYF-----------
--YI--MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRK-FAIGSAR-EADPALNVETEIEILKKL-NHPC--IIKIKNFF-D------AEDYY--IVLELMEGG--ELFDKVV----GNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS-SQEEDCLIKITDFGHSKI--------LGETSLMRTLCGTPTYLAPEVLVS--VGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH--------------RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------EKALDLVKKLLVVDPKA--RFT-----TEEALRHPWL-----------
----YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-RFKNR-------------ELQIMRKL-DHCN--IVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ--------LVRGEPNVSYICSRYYRAPELIF----GATDYTSSIDVWSAGCVLAELLL-GQPIFPGD------------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTA--RLT-----PLEACAHSFF-----------
----YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPF-QNQTHAK-RAYR------ELVLMKCV-NHKN--IISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIQ------MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL---KILDFGLART--------AGTSFMMTPYVVTRYYRAPEVIL-----GMGYKENVDIWSVGCIMGEMVR-HKILFPGR------------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAK--RIS-----VDDALQHPYI-----------
----YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPF-QSIIHAK-RTYR------ELRLLKHM-KHEN--VIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCEL---KILDFGLAR----------HTDDEMTGYVATRWYRAPEIML----NWMHYNQTVDIWSVGCIMAELLT-GRTLFPGT------------DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDK--RIT-----AAQALAHAYF-----------
QLQE----DVLGEGAHARVQTCINLITSQEYAVKIIEKQP-GHIRSR---VFR------EVEMLYQCQGHRN--VLELIEFFEE------EDRFY--LVFEKMRGG--SILSHIH----KRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCE-HPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLS-GYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHIS-----------------------------------CAAKDLISKLLVRDAKQ--RLS-----AAQVLQHPWV-----------
---F-KFGKILGEGSFSTVVLARELATSREYAIKILEKRH-IIKENKVPYVTR------ERDVMSRL-DHPF--FVKLYFTFQD------DEKLY--FGLSYAKNG--ELLKYIR----KIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHI---QITDFGTAKVLS-----PESKQARANSFVGTAQYVSPELLT-----EKSACKSSDLWALGCIIYQLVA-GLPPFRAG---------------NEYLIFQKIIKLEYDFPEKFF---------------------------------------PKARDLVEKLLVLDATK--RLG-----CEEM------EGYGPLKAHPF
----YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDR-ISDWGEL-PNGTRV--PMEVVLLKKV-SSGFSGVIRLLDWFER------PDSFV--LILERPEPV-QDLFDFIT----ERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL---KLIDFGSGA---------LLKDTVYTDFDGTRVYSPPEWIR----YHRYHGRSAAVWSLGILLYDMVC-GDIPFEHD---------------------EEIIRGQVFFRQRVS---------------------------------------SECQHLIRWCLALRPSD--RPT-----FEEIQNHPWM-----------
---L-EIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKH-IVDTKQQ-EHVY-----SEKRILEEL-CSPF--IVKLYRTFKD------NKYVY--MLLEACLGG--ELWSILR----DRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILD-AEGYL---KLVDFGFAKK--------IGSGQKTWTFCGTPEYVAPEVIL-----NKGHDFSVDFWSLGILVYELLT-GNPPFSGV---------------DQMMTYNLILKGIEKMDFPRKIT-------------------------------------RRPEDLIRRLCRQNPTE--RLGNLKNGINDIKKHRWL-----------
----YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFE-MIKRSDS-AFFW-----EERDIMAFA-NSPW--VVQLFYAFQD------DRYLY--MVMEYMPGG--DLVNLMS-----NYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLD-KHGHL---KLADFGTCMKM------DETGMVHCDTAVGTPDYISPEVLKS-QGGDGFYGRECDWWSVGVFLYEMLV-GDTPFYAD---------------SLVGTYSKIMDHKNSLCFPEDAEIS-----------------------------------KHAKNLICAFLTDREVRLGRNG-----VEEIRQHPFF-----------
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