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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK CHEK1 203
AGC AKT1 150
AGC AKT3 148
CMGC CDK2 4
CMGC GSK3A 119
CMGC MAPK13 25
CAMK MAPKAPK2 64
CAMK MARK2 53
CAMK PIM1 38
Other PLK1 53
Other PLK3 62
AGC RPS6KA4 33
AGC SGK1 98
---W-DLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENI-KK----EICIN-KML-NHEN--VVKFYGHRRE------GNIQY--LFLEYCSGG--ELFDRIE--PDIGMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLLLD-ERDNL----KISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQP------SDSCQEYSDWKEKKTYLNPWKKI--D------------------------SAPLALLHKILVENPSARIT-----IPDIKKDRW-Y-
---F-EYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTL---TENRVL-QNS-RHPF--LTALKYSFQT------HDRLC--FVMEYANGG--ELFFHLS--RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD-KDGHI----KITDFGLCKEG--IKDGATMKTFCGTPEYLAPEVLE-DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ-------DHEKLFELILMEEIRFPRTLG----------------------------PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF--
--FD--YLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTL---TESRVL-KNT-RHPF--LTSLKYSFQT------KDRLC--FVMEYVNGG--ELFFHLS--RERVFSEDRTRFYGAEIVSALDYLHS-GKIVYRDLKLENLMLD-KDGHI----KITDFGLCKEG--ITDAATMKTFCGTPEYLAPEVLE-DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ-------DHEKLFELILMEDIKFPRTLS----------------------------SDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFF--
----FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR----EISLL-KEL-NHPN--IVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS-HRVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGD----SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF--
----YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNR----------ELQIM-RKL-DHCN--IVRLRYFFYSSG--EKKDELYLNLVLEYVPETVYRVARHFT-KAKLTIPILYVKVYMYQLFRSLAYIHS-QGVCHRDIKPQNLLVDPDTAVL----KLCDFGSAKQ---LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD----SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--PWTKVFKSRTPPEAIALCSSLLEYTPSSRLS-----PLEACAHSFF--
YVSP----THVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYR----ELLLL-KHM-QHEN--VIGLLDVFTPASSLRNFYDFY--LVMPFMQT---DLQKIM----GMEFSEEKIQYLVYQMLKGLKYIHS-AGVVHRDLKPGNLAVN-EDCEL----KILDFGLAR-----HADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGK----DYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLT-----AAQALTHPFF--
-KVT---SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR-------R----EVELH-WRASQCPH--IVRIVDVYENLY--AGRKCLL--IVMECLDGG--ELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS-INIAHRDVKPENLLYT-SKRPNA-ILKLTDFGFAKE---TTSHNSLTTPCYTPYYVAPEVLG-PEKYDKSCDMWSLGVIMYILLCGYPPFYSN---HGLAISPGMKTRIRMGQYEFPNPEWSEVS------------------------EEVKMLIRNLLKTEPTQRMT-----ITEFMNHPWI--
----YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFR----EVRIM-KVL-NHPN--IVKLFEVIET------EKTLY--LVMEYASGG--EVFDYLV--AHGRMKEKEARAKFRQIVSAVQYCHQ-KFIVHRDLKAENLLLD-ADMNI----KIADFGFSNE---FTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQ-------NLKELRERVLRGKYRIPFYMS----------------------------TDCENLLKKFLILNPSKRGT-----LEQIMKDRWM--
----YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL-KKV-SSGFSGVIRLLDWFER------PDSFV--LILERPEPV-QDLFDFIT--ERGALQEELARSFFWQVLEAVRHCHN-CGVLHRDIKDENILIDLNRGEL----KLIDFGSGA----LLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD-------------EEIIRGQVFFRQRVS----------------------------SECQHLIRWCLALRPSDRPT-----FEEIQNHPWM--
--YV--RGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMS---MEISIH-RSL-AHQH--VVGFHGFFED------NDFVF--VVLELCRRR--SLLELHK--RRKALTEPEARYYLRQIVLGCQYLHR-NRVIHRDLKLGNLFLN-EDLEV----KIGDFGLATKV--EYDGERKKTLCGTPNYIAPEVLS-KKGHSFEVDVWSIGCIMYTLLVGKPPFETS-------CLKETYLRIKKNEYSIPKHIN----------------------------PVAASLIQKMLQTDPTARPT-----INELLNDEFF--
--YL--KGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKIL---NEIELH-RDL-QHRH--IVRFSHHFED------ADNIY--IFLELCSRK--SLAHIWK--ARHTLLEPEVRYYLRQILSGLKYLHQ-RGILHRDLKLGNFFIT-ENMEL----KVGDFGLAARL--EPPEQRKKTICGTPNYVAPEVLL-RQGHGPEADVWSLGCVMYTLLCGSPPFETA-------DLKETYRCIKQVHYTLPASLS----------------------------LPARQLLAAILRASPRDRPS-----IDQILRHDFF--
-REP-----ALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQR---------EVAAL-RLCQSHPN--VVNLHEVHHD------QLHTY--LVLELLRGG--ELLEHIR--KKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYA-DDT-PGAPVKIIDFGFARLR-PQSPGVPMQTPCFTLQYAAPELLA-QQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVS------------------------EEAKELVRGLLTVDPAKRLK-----LEGLRGSSW-L-
----FHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIM---SERNVLLKNV-KHPF--LVGLHFSFQT------ADKLY--FVLDYINGG--ELFYHLQ--RERCFLEPRARFYAAEIASALGYLHS-LNIVYRDLKPENILLD-SQGHI----VLTDFGLCKEN--IEHNSTTSTFCGTPEYLAPEVLH-KQPYDRTVDWWCLGAVLYEMLYGLPPFYSR-------NTAEMYDNILNKPLQLKPNIT----------------------------NSARHLLEGLLQKDRTKRLGAK-DDFMEIKSHV--FF
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