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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK CHEK1 203
AGC AKT1 150
AGC AKT3 148
CMGC GSK3B 56
STE PAK1 270
Other PLK2 82
Other PLK3 62
AGC ROCK1 76
AGC RPS6KB1 91
-W-DLVQTLGEGAYGEVQLAVN---RVTEEAVAVKIVDMKRAVDCPENI-KK--EICINKMLNHENVVKFYGHRRE----GNIQY--LFLEYCSGG--ELFDRIE----PDIGMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLLLD-ERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK---RREFHAEPVDVWSCGIVLTAMLAGELPWDQP--SDSCQEYSDWKEKKTYLNPWKKI--D----------------------SAPLALLHKILVENPSA--RIT-----IPDIKKDRW-Y
-F-EYLKLLGKGTFGKVILVKE---KATGRYYAMKILKKEVIVAKDEVAHTL-TENRVLQNSRHPFLTALKYSFQT----HDRLC--FVMEYANGG--ELFFHLS----RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD-KDGHIKITDFGLCKEG--IKDGATMKTFCGTPEYLAPEVLE----DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ---DHEKLFELILMEEIRFPRTLG--------------------------PEAKSLLSGLLKKDPKQ--RLGGGSEDAKEIMQHRFF-
FD--YLKLLGKGTFGKVILVRE---KASGKYYAMKILKKEVIIAKDEVAHTL-TESRVLKNTRHPFLTSLKYSFQT----KDRLC--FVMEYVNGG--ELFFHLS----RERVFSEDRTRFYGAEIVSALDYLHS-GKIVYRDLKLENLMLD-KDGHIKITDFGLCKEG--ITDAATMKTFCGTPEYLAPEVLE----DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ---DHEKLFELILMEDIKFPRTLS--------------------------SDAKSLLSGLLIKDPNK--RLGGGPDDAKEIMRHSFF-
--YTDTKVIGNGSFGVVYQAKL---CDSGELVAIKKVLQDKRFKNR--------ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS-FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ---LVRGEPNVSYICSRYYRAPELIF---GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTA--RLT-----PLEACAHSFF-
--YTRFEKIGQGASGTVYTAMD---VATGQEVAIKQMNLQQQPKKELII--N--EILVMRENKNPNIVNYLDSYLV----GDELW--VVMEYLAGG--SLTDVVT-----ETCMDEGQIAAVCRECLQALEFLHS-NQVIHRDIKSDNILLG-MDGSVKLTDFGFCAQI--TPEQSKRSTMVGTPYWMAPEVVT----RKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLS--------------------------AIFRDFLNRCLEMDVEK--RGS-----AKELLQHQFL-
-Y-CRGKVLGKGGFAKCYEMTD---LTNNKVYAAKIIPHSRVAKPHQREKID-KEIELHRILHHKHVVQFYHYFED----KENIY--ILLEYCSRR--SMAHILK----ARKVLTEPEVRYYLRQIVSGLKYLHE-QEILHRDLKLGNFFIN-EAMELKVGDFGLAARL--EPLEHRRRTICGTPNYLSPEVLN----KQGHGCESDIWALGCVMYTMLLGRPPFETT---NLKETYRCIREARYTMPSSLL--------------------------APAKHLIASMLSKNPED--RPS-----LDDIIRHDFF-
YL--KGRLLGKGGFARCYEATD---TETGSAYAVKVIPQSRVAKPHQREKIL-NEIELHRDLQHRHIVRFSHHFED----ADNIY--IFLELCSRK--SLAHIWK----ARHTLLEPEVRYYLRQILSGLKYLHQ-RGILHRDLKLGNFFIT-ENMELKVGDFGLAARL--EPPEQRKKTICGTPNYVAPEVLL----RQGHGPEADVWSLGCVMYTLLCGSPPFETA---DLKETYRCIKQVHYTLPASLS--------------------------LPARQLLAAILRASPRD--RPS-----IDQILRHDFF-
--YEVVKVIGRGAFGEVQLVRH---KSTRKVYAMKLLSKFEMIKRSDSAFFW-EERDIMAFANSPWVVQLFYAFQD----DRYLY--MVMEYMPGG--DLVNLMS-----NYDVPEKWARFYTAEVVLALDAIHS-MGFIHRDVKPDNMLLD-KSGHLKLADFGTCMKM-NKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYAD---SLVGTYSKIMNHKNSLTFPDDNDIS----------------------KEAKNLICAFLTDREVRLGRNG-----VEEIKRHLFF-
--FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQT----GGKLY--LILEYLSGG--ELFMQLE----REGIFMEDTACFYLAEISMALGHLHQ-KGIIYRDLKPENIMLN-HQGHVKLTDFGLCKES--IHDGTVTHTFCGTIEYMAPEILM----RSGHNRAVDWWSLGALMYDMLTGAPPFTGE---NRKKTIDKILKCKLNLPPYLT--------------------------QEARDLLKKLLKRNAAS--RLGAGPGDAGEVQAHPFF-
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