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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK CHEK1 203
AGC AKT1 150
AGC AKT3 148
CMGC CDK4 6
CAMK MAPKAPK2 64
TK SRC 270
--WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVD---CPENI-KK-EICINKML-N---HENVVKFYGHRRE-----GNIQYLFLEYCSGGELFDRIE--PDI---GMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLLLDERDNL---KISDFGLATVFRYNNRERLLNK---MCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLA-GELPWDQP---SDSCQEYSDWKEKKTYLNPWKKI--D--------------------SAPLALLHKILVENPSARIT-----IPDIKKDRW-Y
--FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVA---KDEVAHTLTENRVLQNS-R---HPFLTALKYSFQT-----HDRLCFVMEYANGGELFFHLS--RER---VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHI---KITDFGLCKEG--IKDGATMKT---FCGTPEYLAPEVLE-DNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQ----DHEKLFELILMEEIRFPRTLG------------------------PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF-
-FD-YLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIA---KDEVAHTLTESRVLKNT-R---HPFLTSLKYSFQT-----KDRLCFVMEYVNGGELFFHLS--RER---VFSEDRTRFYGAEIVSALDYLHS-GKIVYRDLKLENLMLDKDGHI---KITDFGLCKEG--ITDAATMKT---FCGTPEYLAPEVLE-DNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQ----DHEKLFELILMEDIKFPRTLS------------------------SDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFF-
--YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVR-EVALLRRL-EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPP---GLPAETIKDLMRQFLRGLDFLHA-NCIVHRDLKPENILVTSGGTV---KLADFGLARI---YSYQMALTP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPLFCGN-SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRIS-----AFRALQHSYL-
KVT--SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR----------R-EVELHWRASQ---CPHIVRIVDVYENLY-AGRKCLLIVMECLDGGELFSRIQDRGDQ---AFTEREASEIMKSIGEAIQYLHS-INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE---TTSHNSLTT---PCYTPYYVAPEVLG-PEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS--------------------EEVKMLIRNLLKTEPTQRMT-----ITEFMNHPWI-
--LRLEVKLGQGCFGEVWMGTWN-GTTRVAIKTLK-PGTM----SPEAFL-Q-EAQVMKKL-R---HEKLVQLYAVVS------EEPIYIVTEYMSKGSLLDFLK---GETGKYLRLPQLVDMAAQIASGMAYVER-MNYVHRDLRAANILVGENLVC---KVADFGLARLI--E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGM-VNREVLDQVERGYRMPCPPECP--------------------------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L-
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