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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CLK2 203
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK9 2.7.11.23
CMGC GSK3A 119
CMGC MAPK1 13
YEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAAR---LEINVLEKINEKDPDNKNLCVQMFDWFDY--------HGHMC--ISFELLGL---STFDFLK---DNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFV-NSDYELTYNLEKKRDERSVKSTAVRVVDFGSAT-------FDHEHHSTIVSTRHYRAPEVIL-ELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF
YTKIEKIGEGTYGVVYKGRHKTTGQ-VVAMKKIRLESEEEGVPSTAIREISLLKELR-----HPN-IVSLQDVLMQ--------DSRLY--LIFEFLSM---DLKKYLDSIPPGQYM--DSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI-------------------KLADFGLARAF----GIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP---------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
FQKVEKIGEGTYGVVYKARNKLTGE-VVALKKIRLDTETEGVPSTAIREISLLKELN-----HPN-IVKLLDVIHT--------ENKLY--LVFEFLHQ---DLKKFMDA-SALTGI--PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI-------------------KLADFGLARAF----GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
YEKLAKIGQGTFGEVFKARHRKTGQ-KVALKKVLMENEKEGFPITALREIKILQLLK-----HEN-VVNLIEICRTKASPYNRCKGSIY--LVFDFCEH---DLAGLLS--NVLVKF--TLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVL-------------------KLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF
YTDIKVIGNGSFGVVYQARLAETRE-LVAIKKVLQDKRFKNR------ELQIMRKLD-----HCN-IVRLRYFFYSSG----EKKDELYLNLVLEYVPETVYRVARHFT--KAKLTI--PILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVL-------------------KLCDFGSAKQ-----LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH---------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF
YTNLSYIGEGAYGMVCSAYDNVNKV-RVAIKKISPFEHQTYCQRT-LREIKILLRFR-----HEN-IIGINDIIRAPT---IEQMKDVY--IVQDLMET---DLYKLLK----TQHL--SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDL-------------------KICDFGLARVAD-PDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN-------------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL
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