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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC DMPK 203
CAMK CAMK2G 14
CAMK CHEK1 9
CAMK CHEK2 220
AGC CIT 97
CAMK DAPK1 13
CAMK DAPK2 23
CAMK MARK2 53
CAMK NUAK1 55
CAMK NUAK2 97
CAMK PHKG1 20
AGC PKN2 657
AGC PRKCD 349
AGC PRKCQ 380
CAMK PRKD2 551
AGC RPS6KB1 91
STE SLK 34
STE STK10 36
CAMK STK17A 61
---FEILKVIGRGAFSEVAVVKM---KQTGQVYAMKIMNKWDMLKRGEVSCFR------EERDVLVNG-D---RRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLS-KFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHI----RLADFGSCLKL-RADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKE---HLSLPLVDEGVPEEARDFIQRLLCPP-ETRLGR--GGAG-DFRTHPFF-
---YQLFEELGKGAFSVVRRCVK---KTSTQEYAAKIINTKKLSARDHQKLER-------EARICRLL-K---HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIV--AREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGA-AVKLADFGLAIEV--QGEQQAWFGFAGTPGYLSPEVLR-------KDPYGKPVDIWACGVILYILLVGYPPFWDE---DQHKLYQQIKAGAYDFPSPEWDT-VTPEAKNLINQMLTINPAKRIT-----AD-QALKHPWV-
--W-DLVQTLGEGAYGEVQLAVN---RVTEEAVAVKIVDMKRAVDCPENI-KK-------EICINKML-N---HENVVKFYGHRREGNIQYLFLEYCSGGELFDRIE--PDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNL----KISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK------RREFHAEPVDVWSCGIVLTAMLAGELPWDQP--SDSCQEYSDWKEKKTYLNPWKKI---DSAPLALLHKILVENPSARIT-----IP-DIKKDRW-Y
-YI--MSKTLGSGACGEVKLAFE---RKTCKKVAIKIISKRKFAIGSAREADPALN-VETEIEILKKL-N---HPCIIKIKNFF-DAEDYYIVLELMEGGELFDKVV--GNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDC-LIKITDFGHSKI---LGETSLMRTLCGTPTYLAPEVLVS----VGTAGYNRAVDCWSLGVILFICLSGYPPFSEH--RTQVSLKDQITSGKYNFIPEVWAE-VSEKALDLVKKLLVVDPKARFT-----TE-EALRHPWL-
--F-EVRSLVGCGHFAEVQVVRE---KATGDIYAMKVMKKKALLAQEQVSFFE------EERNILSRS-T---SPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLN-RYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHI----KLVDFGSAAKM-NSNKMVNAKLPIGTPDYMAPEVLTVM-NGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEG---TSARTFNNIMNFQRFLKFPDDPK-VSSDFLDLIQSLLCG-QKERLK-----FE-GLCCHPFF-
---YDTGEELGSGQFAVVKKCRE---KSTGLQYAAKFIKKRRTKSSRRGVSREDI---EREVSILKEI-Q---HPNVITLHEVYENKTDVILILELVAGGELFDFLA--EKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHK---IDFGNEFKNIFGTPEFVAPEIVN-------YEPLGLEADMWSIGVITYILLSGASPFLGD---TKQETLANVSAVNYEFEDEYFSN-TSALAKDFIRRLLVKDPKKRMT-----IQ-DSLQHPWI-
---YDIGEELGSGQFAIVKKCRE---KSTGLEYAAKFIKKRQSRASRRGVSREEI---EREVSILRQV-L---HHNVITLHDVYENRTDVVLILELVSGGELFDFLA--QKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHE---IEDGVEFKNIFGTPEFVAPEIVN-------YEPLGLEADMWSIGVITYILLSGASPFLGD---TKQETLANITAVSYDFDEEFFSQ-TSELAKDFIRKLLVKETRKRLT-----IQ-EALRHPWI-
---YRLLKTIGKGNFAKVKLARH---ILTGKEVAVKIIDKTQLNSSSLQKLFR-------EVRIMKVL-N---HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLV--AHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNI----KIADFGFSNE---FTFGNKLDTFCGSPPYAAPELFQ------GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQ---NLKELRERVLRGKYRIPFYMS-----TDCENLLKKFLILNPSKRGT-----LE-QIMKDRWM-
---YELQETLGKGTYGKVKRATE---RFSGRVVAIKSIRKDKIKDEQDMVHIR------REIEIMSSL-N---HPHIISIYEVFENKDKIVIIMEYASKGELYDYIS--ERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNI----KIADFGLSNL---YQKDKFLQTFCGSPLYASPEIVN------GRPYRGPEVDSWALGVLLYTLVYGTMPFDGF---DHKNLIRQISSGEYREPTQP------SDARGLIRWMLMVNPDRRAT-----IE-DIANHWW-V
---YEFLETLGKGTYGKVKKARE---SSGR-LVAIKSIRKDKIKDEQDLMHIR------REIEIMSSL-N---HPHIIAIHEVFENSSKIVIVMEYASRGDLYDYIS--ERQQLSEREARHFFRQIVSAVHYCHQNRVVHRDLKLENILLDANGNI----KIADFGLSNL---YHQGKFLQTFCGSPLYASPEIVN------GKPYTGPEVDSWSLGVLLYILVHGTMPFDGH---DHKILVKQISNGAYREPPK------PSDACGLIRWLLMVNPTRRAT-----LE-DVASHWW-V
---YEPKEILGRGVSSVVRRCIH---KPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEVDILRKVSG---HPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLT--EKVTLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMNI----KLTDFGFSCQ---LEPGERLREVCGTPSYLAPEIIECS-MNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHR---KQMLMLRMIMSGNYQFGSPEWDD-YSDTVKDLVSRFLVVQPQNRYT-----AE-EALAHPFF-
-FR--CCAVLGRGHFGKVLLAEY---KNTNEMFAIKALKKGDIVARDEVDSLM------CEKRIFETV-NSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIH---TDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFV----KIADFGLCKEG--MGYGDRTSTFCGTPEFLAPEVLT-------ETSYTRAVDWWGLGVLIYEMLVGESPFPGD---DEEEVFDSIVNDEVRYPRFLS-----TEAISIMRRLLRRNPERRLGASEKDAE-DVKKHPFF-
-FI--FHKVLGKGSFGKVLLGEL---KGRGEYFAIKALKKDVVLIDDDVECTM------VEKRVLTLAAE---NPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQ--DKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHI----KIADFGMCKEN--IFGESRASTFCGTPDYIAPEILQ-------GLKYTFSVDWWSFGVLLYEMLIGQSPFHGD---DEDELFESIRVDTPHYPRWIT-----KESKDILEKLFEREPTKRLG----VTG-NIKIHPFF-
-FI--LHKMLGKGSFGKVFLAEF---KKTNQFFAIKALKKDVVLMDDDVECTM------VEKRVLSLAWE---HPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQ--SCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHI----KIADFGMCKEN--MLGDAKTNTFCGTPDYIAPEILL-------GQKYNHSVDWWSFGVLLYEMLIGQSPFHGQ---DEEELFHSIRMDNPFYPRWLE-----KEAKDLLVKLFVREPEKRLG-----VRGDIRQHPLF-
-PD----EVLGSGQFGVVYGGKH---RKTGRDVAVKVIDKLRFPTKQESQLRN-------EVAILQSL-R---HPGIVNLECMFETPEKVFVVMEKLHGDMLEMILS-SEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFP-QVKLCDFGFARI---IGEKSFRRSVVGTPAYLAPEVLL-------NQGYNRSLDMWSVGVIMYVSLSGTFPFNED-----EDINDQIQNAAFMYPASPWSH-ISAGAIDLINNLLQVKMRKRYS-----VD-KSLSHPWL-
---FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTK-----AERNILEEV-K---HPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLE--REGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHV----KLTDFGLCKES--IHDGTVTHTFCGTIEYMAPEILM-------RSGHNRAVDWWSLGALMYDMLTGAPPFTGE---NRKKTIDKILKCKLNLPPYLT-----QEARDLLKKLLKRNAASRLGAGPGDAG-EVQAHPFF-
---WEIIGELGDGAFGKVYKAQN---KETSVLAAAKVIDTKSEEELEDYM--V-------EIDILASC-D---HPNIVKLLDAFYYENNLWILIEFCAGGAVDAVML-ELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDI----KLADFGVSAKN--TRTIQRRDSFIGTPYWMAPEVVMCE--TSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWS-----SNFKDFLKKCLEKNVDARWT-----TS-QLLQHPFV-
---WEIVGELGDGAFGKVYKAKN---KETGALAAAKVIETKSEEELEDYI--V-------EIEILATC-D---HPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIML-ELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDI----RLADFGVSAKN--LKTLQKRDSFIGTPYWMAPEVVMCE--TMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWS-----VEFRDFLKIALDKNPETRPS-----AA-QLLEHPFV-
LCP---GRELGRGKFAVVRKCIK---KDSGKEFAAKFMRKRRKGQDCRMEIIH-------EIAVLELAQD---NPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLG-DIKIVDFGLSRI---LKNSEELREIMGTPEYVAPEILS-------YDPISMATDMWSIGVLTYVMLTGISPFLGN---DKQETFLNISQMNLSYSEEEFDV-LSESAVDFIRTLLVKKPEDRAT-----AE-ECLKHPWL-
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