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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK EGFR 203
TKL BRAF 456
TK ERBB2 720
TK IGF1R 999
TK INSR 1023
TK LCK 245
TK RET 724
TK SRC 270
TK TNK2 150
F-KKIKVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELRE--ATSPKANKEILDEAYVMASVDNPHVCRLLGICL-TSTVQLITQLMPFGCLLDYVREH-----------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLL-GAEEKEYHAEGGKVPIKWMALESILHRI---YTHQSDVWSYGVTVWELMTFGSKPYDGI-PASEISSIL-EKGER----LPQPPICTIDVYMIMVKCWMIDADSRPKFRELI---IEF
-ITVGQRIGSGSFGTVYKGKWH--------GDVAVKMLNV-TAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYST-KPQLAIVTQWCEGSSLYHHLHII-----------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVK-SRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMV-GRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILA--SI-
L-RKVKVLGSGAFGTVYKGIWIP-DGENVKIPVAIKVLRE--NTSPKANKEILDEAYVMAGVGSPYVSRLLGICL-TSTVQLVTQLMPYGCLLDHVREN-----------------------RGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLL-DIDETEYHADGGKVPIKWMALESILRRR---FTHQSDVWSYGVTVWELMTFGAKPYDGI-PAREIPDLL-EKGER----LPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSE-F--
-ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNE--AASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEM--------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDI-YETDYYRKGGKGLLPVRWMSPESLKDGV---FTTYSDVWSFGVVLWEIATLAEQPYQGL-SNEQVLRFV-MEGGL----LDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISS-I--
-ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNE--SASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEA--------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDI-YETDYYRKGGKGLLPVRWMAPESLKDGV---FTTSSDMWSFGVVLWEITSLAEQPYQGL-SNEQVLKFV-MDGGY----LDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL---
-LKLVERLGAGQFGEVWMGYYN------GHTKVAVKSLKQ--GSMSP--DAFLAEANLMKQLQHQRLVRLYAVVT-QEPIYIITEYMENGSLVDFLKTP----------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--EDNEYTAREGAKFPIKWTAPEAINYGT---FTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNL-ERGYR----MVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSV-L--
L-VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKE--NASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDV-YEEDSYVKRSQGRIPVKWMAIESLFDHI---YTTQSDVWSFGVLLWEIVTLGGNPYPGI-PPERLFNLL-KTGHR----MERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL---
L-RLEVKLGQGCFGEVWMGTWN------GTTRVAIKTLKP--GTMSP--EAFLQEAQVMKKLRHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGE----------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEAALYGR---FTIKSDVWSFGILLTELTTKGRVPYPGM-VNREVLDQV-ERGYR----MPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAF-L--
L-RLLEKLGDGSFGVVRRGEWD--APSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVL-TPPMKMVTELAPLGSLLDRLRKH-----------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRT---FSHASDTWMFGVTLWEMFTYGQEPWIGL-NGSQILHKIDKEGER----LPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDF-L--
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