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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK EPHB2 203
TK ABL1 261
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK9 2.7.11.23
TK FGFR1 478
TK LCK 245
TK LYN 247
CMGC MAPK14 24
CAMK MKNK2 84
TK PTK6 191
AGC RPS6KB2 67
TK SRC 270
STE STK10 36
---V-KIEQVIGAGEFGEVCSGHLK----LPGKREI---FVAIKTLK-SGYT-EKQRRDFL-S--EASIMGQF--DHPNVIHLEGVVTK--------STPVMIITEFMENGSLDSFLR----QN---------------DGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVC---KVSDFGLSRFLE--DDT----S--DPTYTSALGGKIPIRWTAPEAIQ-----YRKFTSASDVWSYGIVMWEVMSYGERPYWDM------------TNQDVINAIEQDYRLPPPMDCP-------------------------------SALHQLMLDCWQKDRNHRPK-----FGQIVNTL--
----ITMKHKLGGGQYGEVYEGVWK-------KYSL---TVAVKTLK-EDTM-EV--EEFL-K--EAAVMKEI--KHPNLVQLLGVCTR--------EPPFYIITEFMTYGNLLDYLR----EC--------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLV---KVADFGLSRLM----------T--GDTYTAHAGAKFPIKWTAPESLA-----YNKFSIKSDVWAFGVLLWEIATYGMSPYPGI------------DLSQVYELLEKDYRMERPEGCP-------------------------------EKVYELMRACWQWNPSDRPS-----FAEIHQA--F
----YTKIEKIGEGTYGVVYKGRHK-------TTGQ---VVAMKKIRLESEEEGV--PSTAIR--EISLLKEL--RHPNIVSLQDVLMQ--------DSRLYLIFEFLSM-DLKKYLDSIPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTI---KLADFGLARAF----------GIPIRVYTH---EVVTLWYRSPEVLL----GSARYSTPVDIWSIGTIFAELAT-KKPLFHGD------------SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP---GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYF
----FQKVEKIGEGTYGVVYKARNK-------LTGE---VVALKKIRLDTETEGV--PSTAIR--EISLLKEL--NHPNIVKLLDVIHT--------ENKLYLVFEFLHQ-DLKKFMDA-SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAI---KLADFGLARAF----------GVPVRTYTH---EVVTLWYRAPEILL----GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD------------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF
----YEKLAKIGQGTFGEVFKARHR-------KTGQ---KVALKKVLMENEKEGF--PITALR--EIKILQLL--KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLS--NVLV-----------------KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVL---KLADFGLARAFSL------AKNSQPNRYTN---RVVTLWYRPPELLL----GERDYGPPIDLWGAGCIMAEMWT-RSPIMQGN------------TEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-----SDDALNHDFF
---L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT---KVAVKMLK-SDAT-EKDLSDLI-S--EMEMMKMIG-KHKNIINLLGACTQ--------DGPLYVIVEYASKGNLREYLQ----ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVM---KIADFGLARDI-----H----H--IDYYKKTTNGRLPVKWMAPEALF-----DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV------------PVEELFKLLKEGHRMDKPSNCT-------------------------------NELYMMMRDCWHAVPSQRPT-----FKQLVEDL--
----LKLVERLGAGQFGEVWMGYYN--------GHT---KVAVKSLK-QGSM-SP--DAFL-A--EANLMKQL--QHQRLVRLYAVVT---------QEPIYIITEYMENGSLVDFLK----TP--------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSC---KIADFGLARLI----------E--DNEYTAREGAKFPIKWTAPEAIN-----YGTFTIKSDVWSFGILLTEIVTHGRIPYPGM------------TNPEVIQNLERGYRMVRPDNCP-------------------------------EELYQLMRLCWKERPEDRPT-----FDYLRSV--L
----IKLVKRLGAGQFGEVWMGYYN--------NST---KVAVKTLK-PGTM-SV--QAFL-E--EANLMKTL--QHDKLVRLYAVVTR--------EEPIYIITEYMAKGSLLDFLK----SD--------------EGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMC---KIADFGLARVI----------E--DNEYTAREGAKFPIKWTAPEAIN-----FGCFTIKSDVWSFGILLYEIVTYGKIPYPGR------------TNADVMTALSQGYRMPRVENCP-------------------------------DELYDIMKMCWKEKAEERPT-----FDYLQSV--L
----YQNLSPVGSGAYGSVCAAFDT-------KTGL---RVAVKKLSRPFQSIIH--AKRTYR--ELRLLKHM--KHENVIGLLDVFTPARS--LEEFNDVYLVTHLMGA-DLNNIVK----CQ-----------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCEL---KILDFGLAR-------------HTDDEMTG---YVATRWYRAPEIML----NWMHYNQTVDIWSVGCIMAELLT-GRTLFPGT------------DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-----AAQALAHAYF
QLQE----DVLGEGAHARVQTCINL-------ITSQ---EYAVKIIEKQPGHIRS--R--VFR--EVEMLYQC-QGHRNVLELIEFFEE--------EDRFYLVFEKMRGGSILSHIH---KRR-----------------HFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLN---GDCSPISTPELLT---PCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLS-GYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHIS-------------------------CAAKDLISKLLVRDAKQRLS-----AAQVLQHPWV
---F-TLCRKLGSGYFGEVFEGLWK--------DRV---QVAIKVIS-RDNL-LH-QQMLQ-S--EIQAMKKL--RHKHILALYAVVSV--------GDPVYIITELMAKGSLLELLR----DS--------------DEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLC---KVGDFGLARLI-------------KEDVYLSHDHNIPYKWTAPEALS-----RGHYSTKSDVWSFGILLHEMFSRGQVPYPGM------------SNHEAFLRVDAGYRMPCPLECP-------------------------------PSVHKLMLTCWCRDPEQRPC-----FKALRERL--
----FELLRVLGKGGYGKVFQVRKV-------QGTNLGKIYAMKVLRKAKIVRNA--KDTAHTRAERNILESV--KHPFIVELAYAFQT--------GGKLYLILECLSGGELFTHLE---REG-----------------IFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHI---KLTDFGLCKES----------IHEGAVTHT---FCGTIEYMAPEILV-----RSGHNRAVDWWSLGALMYDMLT-GSPPFTAE---------------NRKKTMDKIIRGKLALPPYLT-----------------------------PDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFF
---L-RLEVKLGQGCFGEVWMGTWN--------GTT---RVAIKTLK-PGTM-SP--EAFL-Q--EAQVMKKL--RHEKLVQLYAVVS---------EEPIYIVTEYMSKGSLLDFLK----GE--------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVC---KVADFGLARLI----------E--DNEYTARQGAKFPIKWTAPEAAL-----YGRFTIKSDVWSFGILLTELTTKGRVPYPGM------------VNREVLDQVERGYRMPCPPECP-------------------------------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L
----WEIVGELGDGAFGKVYKAKNK-------ETGA---LAAAKVIETKSEEELE--DYI--V--EIEILATC--DHPYIVKLLGAYYH--------DGKLWIMIEFCPGGAVDAIML--ELDR-----------------GLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDI---RLADFGVSAKN----------LKTLQKRDS---FIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQ-IEPPHHEL------------NPMRVLLKIAKSDPPTLLTPSKWS-----------------------------VEFRDFLKIALDKNPETRPS-----AAQLLEHPFV
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