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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK EPHB2 203
CMGC CDK2 4
CMGC CDK4 6
CAMK CHEK1 9
CAMK CHEK2 220
TK CSK 195
TK EPHA1 624
TK EPHA4 621
TK EPHA5 675
TK EPHB1 619
TK EPHB3 633
TK EPHB4 615
TK FYN 271
CMGC GSK3B 56
TK HCK 241
TK LCK 245
CMGC MAPK1 13
CMGC MAPK14 24
CMGC MAPK8 26
AGC PDPK1 82
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
TK PTK6 191
TK SRC 270
TK TXK 271
TK YES1 277
--V-KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLK-SGYT----EKQRRD-FL-S------EASIMGQFD---HPNVIHLEGVVT-K------STPVM--IITEFMENG--SLDSFLR-----QN-DGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVN-SNLVC---KVSDFGLSRFLEDDT--S--DPTY-TSALGGKIPIRWTAPEAIQ---YRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCP-----------------------------------------SALHQLMLDCWQKDRNHRPKFGQIVNTL-------------
---FQKVEKIGEGTYGVVYKARNK---LTGEVVALKKIRLDTETE---GV--PS-TAIR------EISLLKELN---HPNIVKLLDVIH-T------ENKLY--LVFEFLHQ---DLKKFMDA--SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI---KLADFGLARAF------GVPVRTY-TH---EVVTLWYRAPEILL--GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-----------
--Y-EPVAEIGVGAYGTVYKARDP---HSGHFVALKSVRVPNGGGGGGGL--PI-STVR------EVALLRRLEAFEHPNVVRLMDVCA-TSR-TDREIKVT--LVFEHVDQ---DLRTYLDK--APPP---GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTV---KLADFGLARI-------YSYQMAL-TP---VVVTLWYRAPEVLL---QSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR---------------PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL-----------
--W-DLVQTLGEGAYGEVQLAVNR---VTEEAVAVKIVDMKRAVD---CP--EN-I-KK------EICINKMLN---HENVVKFYGHRR-E------GNIQY--LFLEYCSGG--ELFDRIE----PDI---GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL---KISDFGLATVFR----YNNRERLL-NK---MCGTLPYVAPELLK--RREFHAEPVDVWSCGIVLTAMLA-GELPWDQP--SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y----------
-YI--MSKTLGSGACGEVKLAFER---KTCKKVAIKIISKRKFAI---GS--AR-EADPALNVETEIEILKKLN---HPCIIKIKNFF--D------AEDYY--IVLELMEGG--ELFDKVV----GNK---RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS-SQEEDCLIKITDFGHSKI-------LGETSLM-RT---LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH--RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL-----------
---LKLLQTIGKGEFGDVMLGDYR-----GNKVAVKCIK-NDAT----AQ---A-FL-A------EASVMTQLR---HSNLVQLLGVIVEE------KGGLY--IVTEYMAKG--SLVDYLR-----SRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVS-EDNVA---KVSDFGLTKEA------------S-STQDTGKLPVKWTAPEALR---EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP-----------------------------------------PAVYEVMKNCWHLDAAMRPSFLQLREQL-------------
-LM--VDTVIGEGEFGEVYRGTLRLPSQDCKTVAIKTLK-DTSP----GGQWWN-FL-R------EATIMGQFS---HPHILHLEGVVT-K------RKPIM--IITEFMENG--ALDAFLR-----ER-EDQLVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVN-QNLCC---KVSDFGLTRLL---D--D--FDGT-YETQGGKIPIRWTAPEAIA---HRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCP-----------------------------------------APLYELMKNCWAYDRARRPHFQKLQAHL-------------
---IKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLK-AGYT----DKQRRD-FL-S------EASIMGQFD---HPNIIHLEGVVT-K------CKPVM--IITEYMENG--SLDAFLR-----KN-DGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVN-SNLVC---KVSDFGMSRVL---E--D--DPEAAYTTRGGKIPIRWTAPEAIA---YRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCP-----------------------------------------IALHQLMLDCWQKERSDRPKFGQIVNML-------------
---ITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLK-VGYT----EKQRRD-FL-G------EASIMGQFD---HPNIIHLEGVVT-K------SKPVM--IVTEYMENG--SLDTFLK-----KN-DGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILIN-SNLVC---KVSDFGLSRVL---E--D--DPEAAYTTRGGKIPIRWTAPEAIA---FRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCP-----------------------------------------AALYQLMLDCWQKERNSRPKFDEIVNML-------------
--V-KIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLK-AGYS----EKQRRD-FL-S------EASIMGQFD---HPNIIRLEGVVT-K------SRPVM--IITEFMENG--ALDSFLR-----QN-DGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVN-SNLVC---KVSDFGLSRYLQDDT--S--DPTY-TSSLGGKIPVRWTAPEAIA---YRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCP-----------------------------------------AALHQLMLDCWQKDRNSRPRFAEIVNTL-------------
--V-KIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLK-VGYT----ERQRRD-FL-S------EASIMGQFD---HPNIIRLEGVVT-K------SRPVM--ILTEFMENC--ALDSFLR-----LN-DGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVN-SNLVC---KVSDFGLSRFLEDDP--S--DPTY-TSSLGGKIPIRWTAPEAIA---YRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCP-----------------------------------------TALHQLMLDCWVRDRNLRPKFSQIVNTL-------------
--V-KIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLK-GGYT----ERQRRE-FL-S------EASIMGQFE---HPNIIRLEGVVT-N------SMPVM--ILTEFMENG--ALDSFLR-----LN-DGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVN-SNLVC---KVSDFGLSRFLEENS--S--DPTY-TSSLGGKIPIRWTAPEAIA---FRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCP-----------------------------------------TSLHQLMLDCWQKDRNARPRFPQVVSAL-------------
---LQLIKRLGNGQFGEVWMGTWN----GNTKVAIKTLK-PGTM----SP--ES-FL-E------EAQIMKKLK---HDKLVQLYAVVS--------EEPIY--IVTEYMNKG--SLLDFLK-----DGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVG-NGLIC---KIADFGLARLI------E--DNEY-TARQGAKFPIKWTAPEAAL---YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCP-----------------------------------------ISLHELMIHCWKKDPEERPTFEYLQSFL-------------
---YTDTKVIGNGSFGVVYQAKLC---DSGELVAIKKVLQDKRFK---NR---------------ELQIMRKLD---HCNIVRLRYFFY-SSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ---TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ-------LVRGEPN-VS---YICSRYYRAPELIF--GATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF-----------
---LKLEKKLGAGQFGEVWMATYN----KHTKVAVKTMK-PGSM----SV--EA-FL-A------EANVMKTLQ---HDKLVKLHAVVT--------KEPIY--IITEFMAKG--SLLDFLK-----SDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVS-ASLVC---KIADFGLARVI------E--DNEY-TAREGAKFPIKWTAPEAIN---FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCP-----------------------------------------EELYNIMMRCWKNRPEERPTFEYIQSV--L-----------
---LKLVERLGAGQFGEVWMGYYN----GHTKVAVKSLK-QGSM----SP--DA-FL-A------EANLMKQLQ---HQRLVRLYAVVT--------QEPIY--IITEYMENG--SLVDFLK-----TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSC---KIADFGLARLI------E--DNEY-TAREGAKFPIKWTAPEAIN---YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP-----------------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L-----------
---YTNLSYIGEGAYGMVCSAYDN---VNKVRVAIKKISPFEHQT---YC--QR-T-LR------EIKILLRFR---HENIIGINDIIR-APT-IEQMKDVY--IVQDLMET---DLYKLLK-----TQ---HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDL---KICDFGLARVAD---PDHDHTGFL-TE---YVATRWYRAPEIML--NSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN-----------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL-----------
---YQNLSPVGSGAYGSVCAAFDT---KTGLRVAVKKLSRPFQSI---IH--AK-RTYR------ELRLLKHMK---HENVIGLLDVFT-PARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQ---KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCEL---KILDFGLAR---------HTDDEM-TG---YVATRWYRAPEIML--NWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF-----------
---YQNLKPIGSGAQGIVCAAYDA---ILERNVAIKKLSRPFQNQ---TH--AK-RAYR------ELVLMKCVN---HKNIIGLLNVFT-PQKSLEEFQDVY--IVMELMDA---NLCQVIQ------M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL---KILDFGLART-------AGTSFMM-TP---YVVTRYYRAPEVIL---GMGYKENVDLWSVGCIMGEMVC-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI-----------
--F-KFGKILGEGSFSTVVLAREL---ATSREYAIKILEKRHIIK---EN--KVPYVTR------ERDVMSRLD---HPFFVKLYFTFQ-D------DEKLY--FGLSYAKNG--ELLKYIR----KIG---SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHI---QITDFGTAKVLS----PESKQARA-NS---FVGTAQYVSPELLT---EKSACKSSDLWALGCIIYQLVA-GLPPFRAG---NEYLIFQKIIKLEYDFPEKFF---------------------------------------PKARDLVEKLLVLDATKRLGCEEM------EGYGPLKAHPF
-PD----EVLGSGQFGIVYGGKHR---KTGRDVAIKIIDKLRFPT---KQ--ES-QLRN------EVAILQNLH---HPGVVNLECMFE-T------PERVF--VVMEKLHGD--MLEMILS---SEKG---RLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLA-SADPFPQVKLCDFGFARI-------IGEKSFR-RS---VVGTPAYLAPEVLR---NKGYNRSLDMWSVGVIIYVSLS-GTFPFNED-----EDIHDQIQNAAFMYPPNPWKEIS-----------------------------------HEAIDLINNLLQVKMRKRYSVDKTLSHPWL-----------
-PD----EVLGSGQFGVVYGGKHR---KTGRDVAVKVIDKLRFPT---KQ--ES-QLRN------EVAILQSLR---HPGIVNLECMFE-T------PEKVF--VVMEKLHGD--MLEMILS---SEKG---RLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLA-SADPFPQVKLCDFGFARI-------IGEKSFR-RS---VVGTPAYLAPEVLL---NQGYNRSLDMWSVGVIMYVSLS-GTFPFNED-----EDINDQIQNAAFMYPASPWSHIS-----------------------------------AGAIDLINNLLQVKMRKRYSVDKSLSHPWL-----------
FAD----EVLGSGQFGIVYGGKHR---KTGRDVAIKVIDKMRFPT---KQ--ES-QLRN------EVAILQNLH---HPGIVNLECMFE-T------PERVF--VVMEKLHGD--MLEMILS---SEKS---RLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLA-SAEPFPQVKLCDFGFARI-------IGEKSFR-RS---VVGTPAYLAPEVLR---SKGYNRSLDMWSVGVIIYVSLS-GTFPFNED-----EDINDQIQNAAFMYPPNPWREIS-----------------------------------GEAIDLINNLLQVKMRKRYSVDKSLSHPWL-----------
--F-TLCRKLGSGYFGEVFEGLWK----DRVQVAIKVIS-RDNL----LH-QQM-LQ-S------EIQAMKKLR---HKHILALYAVVS-V------GDPVY--IITELMAKG--SLLELLR-----DSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVG-ENTLC---KVGDFGLARLI---------KEDV-YLSHDHNIPYKWTAPEALS---RGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECP-----------------------------------------PSVHKLMLTCWCRDPEQRPCFKALRERL-------------
--L-RLEVKLGQGCFGEVWMGTWN----GTTRVAIKTLK-PGTM----SP--EA-FL-Q------EAQVMKKLR---HEKLVQLYAVVS--------EEPIY--IVTEYMSKG--SLLDFLK-----GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVC---KVADFGLARLI------E--DNEY-TARQGAKFPIKWTAPEAAL---YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP-----------------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L-----------
--L-AFIKEIGSGQFGVVHLGEWR----SHIQVAIKAIN-EGSM----SE--ED-FI-E------EAKVMMKLS---HSKLVQLYGVCI-Q------RKPLY--IVTEFMENG--CLLNYLR-----EN-KGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVS-STCIV---KISDFGMTRYV------L--DDEY-VSSFGAKFPIKWSPPEVFL---FNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAP-----------------------------------------MSIYEVMYSCWHEKPEGRPTFAELLR---AV----------
--L-RLEVKLGQGCFGEVWMGTWN----GTTKVAIKTLK-PGTM----MP--EA-FL-Q------EAQIMKKLR---HDKLVPLYAVVS--------EEPIY--IVTEFMSKG--SLLDFLK-----EGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVG-ENLVC---KIADFGLARLI------E--DNEY-TARQGAKFPIKWTAPEAAL---YGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCP-----------------------------------------ESLHELMNLCWKKDPDERPTFEYIQSFL-------------
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