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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK EPHB2 203
TK ABL1 261
CMGC CDC2 4
TK EGFR 712
TK EPHA6 631
TK EPHB4 615
TK ERBB4 718
TK FGFR1 478
TK FLT4 845
TK IGF1R 999
TK INSR 1023
TK ITK 363
TK KDR 834
TK LCK 245
TK RET 724
TK SRC 270
TK TEK 824
TK YES1 277
------V-KIEQVIGAGEFGEVCSGHLK----LPGKREIFVAIKTLK-SGYT-EKQRRDFL-SEASIMGQF-DHPNVIHLEGVVT-KSTPVMIITEFMENGSLDSFLR----QN-----------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTS--DPTY-TSALGGKIPIRWTAPEAIQ-YRKFTSASDVWSYGIVMWEVMSYGERPYWDM-TNQDVINAIEQDYRLPPPMDCP----------------------------SALHQLMLDCWQKDRNHRPKFGQIVNTL----
-------ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-EDTM-EV--EEFL-KEAAVMKEI-KHPNLVQLLGVCT-REPPFYIITEFMTYGNLLDYLR----EC----------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM----T--GDTY-TAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELLEKDYRMERPEGCP----------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F--
-------YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKIRLESEEEGV--PSTAIREISLLKEL-RHPNIVSLQDVLM-QDSRLYLIFEFLSM-DLKKYLDSIPPGQ-------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF----GIPIRVY-TH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--
------F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-EATS-PKANKEIL-DEAYVMASV-DNPHVCRLLGICL--TSTVQLITQLMPFGCLLDYVR----EH-----------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLL---GA--EEKE-YHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGI-PASEISSILEKGERLPQPPICT----------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF
LPPRIPA--------------------------------------------------------------------------------GRPVMIVVEYMENGSLDSFLR----KH-----------------------------------------------------------------DGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVL---ED--DPEAAYTTTGGKIPIRWTAPEAIA-YRKFSSASDAWSYGIVMWEVMSYGERPYWEM-SNQDVILSIEEGYRLPAPMGCP----------------------------ASLHQLMLHCWQKERNHRPKFTDIVSFL----
------V-KIEEVIGAGEFGEVCRGRLK----APGKKESCVAIKTLK-GGYT-ERQRREFL-SEASIMGQF-EHPNIIRLEGVVT-NSMPVMILTEFMENGALDSFLR----LN-----------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSS--DPTY-TSSLGGKIPIRWTAPEAIA-FRKFTSASDAWSYGIVMWEVMSFGERPYWDM-SNQDVINAIEQDYRLPPPPDCP----------------------------TSLHQLMLDCWQKDRNARPRFPQVVSAL----
------L-KRVKVLGSGAFGTVYKGIWVP---EGETVKIPVAIKILN-ETTG-PKANVEFM-DEALIMASM-DHPHLVRLLGVCL--SPTIQLVTQLMPHGCLLEYVH----EH-----------------------------------------------------------------KDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLL---EG--DEKE-YNADGGKMPIKWMALECIH-YRKFTHQSDVWSYGVTIWELMTFGGKPYDGI-PTREIPDLLEKGERLPQPPICT----------------------------IDVYMVMVKCWMIDADSRPKFKELAAE--F--
------L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SDAT-EKDLSDLI-SEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKGNLREYLQ----ARRPPGLEY--------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI---HH--IDYY-KKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELFKLLKEGHRMDKPSNCT----------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL----
-------LHLGRVLGYGAFGKVVEASAFG--IHKGSSCDTVAVKMLK-EGAT-ASEHRALM-SELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLR----AKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR--PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDI---YK--DPDY-VRKGSARLPLKWMAPESIF-DKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELAT----------------------------PAIRRIMLNCWSGDPKARPAFSELVEIL----
-------ITMSRELGQGSFGMVYEGVAKG--VVKDEPETRVAIKTVN-EAAS-MRERIEFL-NEASVMKEF-NCHHVVRLLGVVS-QGQPTLVIMELMTRGDLKSYLR----SLRPEM--------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDI---YE--TDYY-RKGGKGLLPVRWMSPESLK-DGVFTTYSDVWSFGVVLWEIATLAEQPYQGL-SNEQVLRFVMEGGLLDKPDNCP----------------------------DMLFELMRMCWQYNPKMRPSFLEIISS--I--
-------ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVN-ESAS-LRERIEFL-NEASVMKGF-TCHHVVRLLGVVS-KGQPTLVVMELMAHGDLKSYLR----SLRPEA--------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDI---YE--TDYY-RKGGKGLLPVRWMAPESLK-DGVFTTSSDMWSFGVVLWEITSLAEQPYQGL-SNEQVLKFVMDGGYLDQPDNCP----------------------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL----
-------LTFVQEIGSGQFGLVHLGYWL--------NKDKVAIKTIR-EGAM-SE--EDFI-EEAEVMMKL-SHPKLVQLYGVCL-EQAPICLVFEFMEHGCLSDYLR----TQ-----------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFV----L--DDQY-TSSTGTKFPVKWASPEVFS-FSRYSSKSDVWSFGVLMWEVFSEGKIPYENR-SNSEVVEDISTGFRLYKPRLAS----------------------------THVYQIMNHCWKERPEDRPAFSRLLRQL----
-------LKLGKPLGRGAFGQVIEADAFG--IDKTATCRTVAVKMLK-EGAT-HSEHRALM-SELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLR----SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDI---YK--DPDY-VRKGDARLPLKWMAPETIF-DRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTT----------------------------PEMYQTMLDCWHGEPSQRPTFSELVEHL----
-------LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-QGSM-SP--DAFL-AEANLMKQL-QHQRLVRLYAVVT--QEPIYIITEYMENGSLVDFLK----TP----------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI----E--DNEY-TAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNLERGYRMVRPDNCP----------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L--
------L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-ENAS-PSELRDLL-SEFNVLKQV-NHPHVIKLYGACS-QDGPLLLIVEYAKYGSLRGFLR----ESRKVGPGYLGSG------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDV---YE--EDSY-VKRSQGRIPVKWMAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI-PPERLFNLLKTGHRMERPDNCS----------------------------EEMYRLMLQCWKQEPDKRPVFADISKDL----
------L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-PGTM-SP--EAFL-QEAQVMKKL-RHEKLVQLYAVVS--EEPIYIVTEYMSKGSLLDFLK----GE----------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI----E--DNEY-TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGM-VNREVLDQVERGYRMPCPPECP----------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L--
-------IKFQDVIGEGNFGQVLKARIK-----KDGLRMDAAIKRMK-EYAS-KDDHRDFA-GELEVLCKLGHHPNIINLLGACE-HRGYLYLAIEYAPHGNLLDFLR----KSRVLETDP--------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ--------EVY-VKKTMGRLPVRWMAIESLN-YSVYTTNSDVWSYGVLLWEIVSLGGTPYCGM-TCAELYEKLPQGYRLEKPLNCD----------------------------DEVYDLMRQCWREKPYERPSFAQILV---SL-
------L-RLEVKLGQGCFGEVWMGTWN--------GTTKVAIKTLK-PGTM-MP--EAFL-QEAQIMKKL-RHDKLVPLYAVVS--EEPIYIVTEFMSKGSLLDFLK----EG----------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLI----E--DNEY-TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILQTELVTKGRVPYPGM-VNREVLEQVERGYRMPCPQGCP----------------------------ESLHELMNLCWKKDPDERPTFEYIQSFL----
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