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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK EPHB2 203
TK ABL1 261
CMGC CDC2 4
CMGC CDK2 4
TK CSK 195
TK EGFR 712
TK EPHA4 621
TK EPHA5 675
TK EPHA6 631
TK EPHB1 619
TK EPHB3 633
TK EPHB4 615
TK FGFR1 478
TK FGFR2 481
TK FYN 271
TK JAK2 849
TK JAK3 822
TK KDR 834
TK LCK 245
STE MAP4K4 25
CMGC MAPK14 24
TK PTK6 191
TK RET 724
TK SRC 270
TK TEK 824
TK TNK2 150
TK YES1 277
------V-KIEQVIGAGEFGEVCSGHLK----LPGKREIFVAIKTLK-S--GYT-EKQRRDFL-SEASIMGQF--DHPNVIHLEGVVT--K------STPVMIITEFMENGSLDSFLR----QN-----------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTS--DPTY-TSALGGKIPIRWTAPEAIQ-----YRKFTSASDVWSYGIVMWEVMSYGERP---------------YWDM-TNQDVINAI-EQDYRLPPPMDCP------------------------------SALHQLMLDCWQKDRNHRPKFGQIVNTL----
-------ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-E--DTM-EV--EEFL-KEAAVMKEI--KHPNLVQLLGVCT--R------EPPFYIITEFMTYGNLLDYLR----EC----------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM----T--GDTY-TAHAGAKFPIKWTAPESLA-----YNKFSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-DLSQVYELL-EKDYRMERPEGCP------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F--
-------YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKIRLE--SEEEGV--PSTAIREISLLKEL--RHPNIVSLQDVLM--Q------DSRLYLIFEFLSM-DLKKYLDSIPPGQ-------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF----GIPIRVY-TH---EVVTLWYRSPEVLL----GSARYSTPVDIWSIGTIFAELAT-KKPL---------------FHGD-SEIDQLFRI-FRALGTPNNEVWPEVESLQDYKNTFPKWKP--GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--
-------FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLD--TETEGV--PSTAIREISLLKEL--NHPNIVKLLDVIH--T------ENKLYLVFEFLHQ-DLKKFMDA-SALT-------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF----GVPVRTY-TH---EVVTLWYRAPEILL----GCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
-------LKLLQTIGKGEFGDVMLGDYR---------GNKVAVKCIK-N--DAT-AQ---AFL-AEASVMTQL--RHSNLVQLLGVIV-EE------KGGLYIVTEYMAKGSLVDYLR----SR----------------------------------------------------------------GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA----------S-STQDTGKLPVKWTAPEALR-----EKKFSTKSDVWSFGILLWEIYSFGRVP---------------YPRI-PLKDVVPRV-EKGYKMDAPDGCP------------------------------PAVYEVMKNCWHLDAAMRPSFLQLREQL----
------F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-E--ATS-PKANKEIL-DEAYVMASV--DNPHVCRLLGICL---------TSTVQLITQLMPFGCLLDYVR----EH-----------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLL---GA--EEKE-YHAEGGKVPIKWMALESIL-----HRIYTHQSDVWSYGVTVWELMTFGSKP---------------YDGI-PASEISSIL-EKGERLPQPPICT------------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF
-------IKIEKVIGVGEFGEVCSGRLK----VPGKREICVAIKTLK-A--GYT-DKQRRDFL-SEASIMGQF--DHPNIIHLEGVVT--K------CKPVMIITEYMENGSLDAFLR----KN-----------------------------------------------------------------DGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVL---ED--DPEAAYTTRGGKIPIRWTAPEAIA-----YRKFTSASDVWSYGIVMWEVMSYGERP---------------YWDM-SNQDVIKAI-EEGYRLPPPMDCP------------------------------IALHQLMLDCWQKERSDRPKFGQIVNML----
-------ITIERVIGAGEFGEVCSGRLK----LPGKRELPVAIKTLK-V--GYT-EKQRRDFL-GEASIMGQF--DHPNIIHLEGVVT--K------SKPVMIVTEYMENGSLDTFLK----KN-----------------------------------------------------------------DGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVL---ED--DPEAAYTTRGGKIPIRWTAPEAIA-----FRKFTSASDVWSYGIVMWEVVSYGERP---------------YWEM-TNQDVIKAV-EEGYRLPSPMDCP------------------------------AALYQLMLDCWQKERNSRPKFDEIVNML----
LPPRIPA------------------------------------------------------------------------------------------GRPVMIVVEYMENGSLDSFLR----KH-----------------------------------------------------------------DGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVL---ED--DPEAAYTTTGGKIPIRWTAPEAIA-----YRKFSSASDAWSYGIVMWEVMSYGERP---------------YWEM-SNQDVILSI-EEGYRLPAPMGCP------------------------------ASLHQLMLHCWQKERNHRPKFTDIVSFL----
------V-KIEEVIGAGEFGEVYKGRLK----LPGKREIYVAIKTLK-A--GYS-EKQRRDFL-SEASIMGQF--DHPNIIRLEGVVT--K------SRPVMIITEFMENGALDSFLR----QN-----------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTS--DPTY-TSSLGGKIPVRWTAPEAIA-----YRKFTSASDVWSYGIVMWEVMSFGERP---------------YWDM-SNQDVINAI-EQDYRLPPPMDCP------------------------------AALHQLMLDCWQKDRNSRPRFAEIVNTL----
------V-KIEEVIGAGEFGEVCRGRLK----QPGRREVFVAIKTLK-V--GYT-ERQRRDFL-SEASIMGQF--DHPNIIRLEGVVT--K------SRPVMILTEFMENCALDSFLR----LN-----------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPS--DPTY-TSSLGGKIPIRWTAPEAIA-----YRKFTSASDVWSYGIVMWEVMSYGERP---------------YWDM-SNQDVINAV-EQDYRLPPPMDCP------------------------------TALHQLMLDCWVRDRNLRPKFSQIVNTL----
------V-KIEEVIGAGEFGEVCRGRLK----APGKKESCVAIKTLK-G--GYT-ERQRREFL-SEASIMGQF--EHPNIIRLEGVVT--N------SMPVMILTEFMENGALDSFLR----LN-----------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSS--DPTY-TSSLGGKIPIRWTAPEAIA-----FRKFTSASDAWSYGIVMWEVMSFGERP---------------YWDM-SNQDVINAI-EQDYRLPPPPDCP------------------------------TSLHQLMLDCWQKDRNARPRFPQVVSAL----
------L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-S--DAT-EKDLSDLI-SEMEMMKMIG-KHKNIINLLGACT--Q------DGPLYVIVEYASKGNLREYLQ----ARRPPGLEY--------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI---HH--IDYY-KKTTNGRLPVKWMAPEALF-----DRIYTHQSDVWSFGVLLWEIFTLGGSP---------------YPGV-PVEELFKLL-KEGHRMDKPSNCT------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL----
-------LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-D--DAT-EKDLSDLV-SEMEMMKMIG-KHKNIINLLGACT--Q------DGPLYVIVEYASKGNLREYLR----ARRPPGMEY--------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI---NN--IDYY-KKTTNGRLPVKWMAPEALF-----DRVYTHQSDVWSFGVLMWEIFTLGGSP---------------YPGI-PVEELFKLL-KEGHRMDKPANCT------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL----
-------LQLIKRLGNGQFGEVWMGTWN--------GNTKVAIKTLK-P--GTM-SP--ESFL-EEAQIMKKL--KHDKLVQLYAVVS---------EEPIYIVTEYMNKGSLLDFLK----DG----------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLI----E--DNEY-TARQGAKFPIKWTAPEAAL-----YGRFTIKSDVWSFGILLTELVTKGRVP---------------YPGM-NNREVLEQV-ERGYRMPCPQDCP------------------------------ISLHELMIHCWKKDPEERPTFEYLQSFL----
-------LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKLQ-H--STE--EHLRDFE-REIEILKSL--QHDNIVKYKGVCYSAG------RRNLKLIMEYLPYGSLRDYLQ----KH-----------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVL--PQD--KEYY-KVKEPGESPIFWYAPESLT-----ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELL-KNNGRLPRPDGCP------------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
------L-KYISQLGKGNFGSVELCRYDP---LGDNTGALVAVKQLQ-H--SGP-DQ-QRDFQ-REIQILKAL--HSDFIVKYRGVSYGPG------RQSLRLVMEYLPSGCLRDFLQ----RH-----------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLL--PLD--KDYY-VVREPGQSPIFWYAPESLS-----DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELL-EEGQRLPAPPACP------------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL-
-------LKLGKPLGRGAFGQVIEADAFG--IDKTATCRTVAVKMLK-E--GAT-HSEHRALM-SELKILIHIG-HHLNVVNLLGACT-KP------GGPLMVIVEFCKFGNLSTYLR----SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDI---YK--DPDY-VRKGDARLPLKWMAPETIF-----DRVYTIQSDVWSFGVLLWEIFSLGASP---------------YPGVKIDEEFCRRL-KEGTRMRAPDYTT------------------------------PEMYQTMLDCWHGEPSQRPTFSELVEHL----
-------LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-Q--GSM-SP--DAFL-AEANLMKQL--QHQRLVRLYAVVT---------QEPIYIITEYMENGSLVDFLK----TP----------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI----E--DNEY-TAREGAKFPIKWTAPEAIN-----YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNL-ERGYRMVRPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L--
-------FELVEVVGNGTYGQVYKGRHV-------KTGQLAAIKVMDVT--EDEEEE--IKL---EINMLKKY-SHHRNIATYYGAFI--KKSPPGHDDQLWLVMEFCGAGSITDLVKN-TKGN-------------------------------------------------------------------TLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQL----DRTVGRR-NT---FIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAE-GAPP---------------LCDM-HPMRALFLI-PRNPPPRLKSKKWS-----------------------------KKFFSFIEGCLVKNYMQRPSTEQLLKHPFI--
-------YQNLSPVGSGAYGSVCAAFDT-------KTGLRVAVKKLSRP--FQSIIH--AKRTYRELRLLKHM--KHENVIGLLDVFT--PARSLEEFNDVYLVTHLMGA-DLNNIVK----CQ-------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-------HTDDEM-TG---YVATRWYRAPEIML----NWMHYNQTVDIWSVGCIMAELLT-GRTL---------------FPGT-DHIDQLKLI-LRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF--
------F-TLCRKLGSGYFGEVFEGLWK--------DRVQVAIKVIS-R--DNL-LH-QQMLQ-SEIQAMKKL--RHKHILALYAVVS--V------GDPVYIITELMAKGSLLELLR----DS----------------------------------------------------------------DEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLI-------KEDV-YLSHDHNIPYKWTAPEALS-----RGHYSTKSDVWSFGILLHEMFSRGQVP---------------YPGM-SNHEAFLRV-DAGYRMPCPLECP------------------------------PSVHKLMLTCWCRDPEQRPCFKALRERL----
------L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-E--NAS-PSELRDLL-SEFNVLKQV--NHPHVIKLYGACS--Q------DGPLLLIVEYAKYGSLRGFLR----ESRKVGPGYLGSG------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDV---YE--EDSY-VKRSQGRIPVKWMAIESLF-----DHIYTTQSDVWSFGVLLWEIVTLGGNP---------------YPGI-PPERLFNLL-KTGHRMERPDNCS------------------------------EEMYRLMLQCWKQEPDKRPVFADISKDL----
------L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-P--GTM-SP--EAFL-QEAQVMKKL--RHEKLVQLYAVVS---------EEPIYIVTEYMSKGSLLDFLK----GE----------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI----E--DNEY-TARQGAKFPIKWTAPEAAL-----YGRFTIKSDVWSFGILLTELTTKGRVP---------------YPGM-VNREVLDQV-ERGYRMPCPPECP------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L--
-------IKFQDVIGEGNFGQVLKARIK-----KDGLRMDAAIKRMK-E--YAS-KDDHRDFA-GELEVLCKLG-HHPNIINLLGACE--H------RGYLYLAIEYAPHGNLLDFLR----KSRVLETDP--------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ--------EVY-VKKTMGRLPVRWMAIESLN-----YSVYTTNSDVWSYGVLLWEIVSLGGTP---------------YCGM-TCAELYEKL-PQGYRLEKPLNCD------------------------------DEVYDLMRQCWREKPYERPSFAQILV---SL-
------L-RLLEKLGDGSFGVVRRGEWD----APSGKTVSVAVKCLK-PDVLSQ-PEAMDDFI-REVNAMHSL--DHRNLIRLYGVVL---------TPPMKMVTELAPLGSLLDRLR----KH-----------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRAL--PQN--DDHY-VMQEHRKVPFAWCAPESLK-----TRTFSHASDTWMFGVTLWEMFTYGQEP---------------WIGL-NGSQILHKIDKEGERLPRPEDCP------------------------------QDIYNVMVQCWAHKPEDRPTFVALRDF--L--
------L-RLEVKLGQGCFGEVWMGTWN--------GTTKVAIKTLK-P--GTM-MP--EAFL-QEAQIMKKL--RHDKLVPLYAVVS---------EEPIYIVTEFMSKGSLLDFLK----EG----------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLI----E--DNEY-TARQGAKFPIKWTAPEAAL-----YGRFTIKSDVWSFGILQTELVTKGRVP---------------YPGM-VNREVLEQV-ERGYRMPCPQGCP------------------------------ESLHELMNLCWKKDPDERPTFEYIQSFL----
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