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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK EPHB4 203
TK ALK 1116
TK CSK 195
TK FGFR1 478
TK LCK 245
TK SRC 270
V-KIEEVIGAGEFGEVCRGRLK----APGKKESCVAIKTLKGGYTERQRREFLSEASIMGQF-EHPNIIRLEGVVT-NSMPVMILTEFMENGALDSFLRLN---------------DGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNS---NLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSAL-
I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKF-NHQNIVRCIGVSL-QSLPRFILLELMAGGDLKSFLRETRP---------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI---YRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILER-I
-LKLLQTIGKGEFGDVMLGDYR---------GNKVAVKCIKNDATAQ---AFLAEASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR--------------GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSE---DNVAKVSDFGLTKEA--------SSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQL-
L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVMKIADFGLARDI---HHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL-
-LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLKQGSMSP--DAFLAEANLMKQL-QHQRLVRLYAVVT--QEPIYIITEYMENGSLVDFLKTP--------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD---TLSCKIADFGLARLI----EDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSV-L
L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLKPGTMSP--EAFLQEAQVMKKL-RHEKLVQLYAVVS--EEPIYIVTEYMSKGSLLDFLKGE--------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLI----EDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAF-L
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