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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK FGFR3 203
TK ABL1 261
TK ALK 1116
Other AURKA 133
Other AURKC 43
TKL BRAF 456
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK5 4
TK CSF1R 582
TK EGFR 712
Other EIF2AK2 267
TK FGFR1 478
TK HCK 241
TK IGF1R 999
TK INSR 1023
TK JAK2 849
TK KIT 589
TK LCK 245
TK LYN 247
CMGC MAPK14 24
TK NTRK1 510
TK PDGFRA 593
TK PDGFRB 600
TK RET 724
CAMK SIK1 27
TK SRC 270
TKL TGFBR1 205
--LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLK-D-D-AT-DKDLSDLV-S-EMEMMKMIGKHKNIINLLGACT--Q-----------------------------GGPLYVLVEYAAKGNLREFLR----ARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQ--------KCIHRDLAARNVLVTE---DNVMKIADFGLARDV---H--N--LDYYKKTTNGRLPVKWMAPEALF------DRV---YTHQSDVWSFGVLLWEIFTLGG----------SP---------------YPGI-----PVEELFKLLKEGHR----MDKPANCT------------------------------HDLYMIMRECWHAAPSQRPTFKQLVEDL-----
--ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-E-D-TM-EV--EEFL-K-EAAVMKEI-KHPNLVQLLGVCT--R-----------------------------EPPFYIITEFMTYGNLLDYLR----EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVGE---NHLVKVADFGLSRLM------T--GDTYTAHAGAKFPIKWTAPESLA------YNK---FSIKSDVWAFGVLLWEIATYGM----------SP---------------YPGI-----DLSQVYELLEKDYR----MERPEGCP------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F---
-I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLP-E-V-CS-EQDELDFL-M-EALIISKF-NHQNIVRCIGVSL--Q-----------------------------SLPRFILLELMAGGDLKSFLR----ETRP--------------------------------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEEN--------HFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI---Y--R--ASYYRKGGCAMLPVKWMPPEAFM------EGI---FTSKTDTWSFGVLLWEIFSLGY----------MP---------------YPSK-----SNQEVLEFVTSGGR----MDPPKNCP------------------------------GPVYRIMTQCWQHQPEDRPNFAIILER--I---
--FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKA-QLEKAGV--EHQLRR-EVEIQSHL-RHPNILRLYGYFH--D-----------------------------ATRVYLILEYAPLGTVYRELQ---KLS----------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSK--------RVIHRDIKPENLLLGS---AGELKIADFGWSV--------HAPSSRRTT---LCGTLDYLPPEMIE------GRM---HDEKVDLWSLGVLCYEFLV-GK----------PP---------------FEAN--------TYQETYKRISR----VEFTFPDFVT----------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI---
--FEIGRPLGKGKFGNVYLARLK-------ESHFIVALKVLFKS-Q-IEKEG--LEHQLRREIEIQAHL-QHPNILRLYNYFH--D-----------------------------ARRVYLILEYAPRGELYKELQ---KSE----------------------------------------------------------------------------------------------------KLDEQRTATIIEELADALTYCHDK--------KVIHRDIKPENLLLGF---RGEVKIADFGWSV--------HTPSLRRKT---MCGTLDYLPPEMIE------GRT---YDEKVDLWCIGVLCYELLV-GY----------PP---------------FESA--------SHSETYRRILK----VDVRFPLSMP----------------------------LGARDLISRLLRYQPLERLPLAQILKHPWV---
--ITVGQRIGSGSFGTVYKGKWH----------GDVAVKMLN-VTA-PT-PQQLQAFK-N-EVGVLRKT-RHVNILLFMGYST--------------------------------KPQLAIVTQWCEGSSLYHHLH----II--------------------------------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAK--------SIIHRDLKSNNIFLHE---DLTVKIGDFGLATVK---S--R--WSGSHQFEQLSGSILWMAPEVIR------MQDKNPYSFQSDVYAFGIVLYELMT-GQ----------LP---------------YSNI-N---NRDQIIFMVGRGYLSPDLSKVRSNCP------------------------------KAMKRLMAECLKKKRDERPLFPQILA---SI--
--YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKIRLE-S-EEEGV--PSTAIR-EISLLKEL-RHPNIVSLQDVLM--Q-----------------------------DSRLYLIFEFLSM-DLKKYLDSIPPGQ----------------------------------------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHSR--------RVLHRDLKPQNLLIDD---KGTIKLADFGLARAF------GIPIRVYTH---EVVTLWYRSPEVLL-----GSAR---YSTPVDIWSIGTIFAELAT-KK----------PL---------------FHGD-----SEIDQLFRIFRALG----TPNNEVWPEVESLQDYKNTFPKWKP--GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF---
--FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLD-T-ETEGV--PSTAIR-EISLLKEL-NHPNIVKLLDVIH--T-----------------------------ENKLYLVFEFLHQ-DLKKFMDA-SALT----------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSH--------RVLHRDLKPQNLLINT---EGAIKLADFGLARAF------GVPVRTYTH---EVVTLWYRAPEILL-----GCKY---YSTAVDIWSLGCIFAEMVT-RR----------AL---------------FPGD-----SEIDQLFRIFRTLG----TPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF---
--YEKLEKIGEGTYGTVFKAKNR-------ETHEIVALKRVRLD-D-DDEGV--PSSALR-EICLLKEL-KHKNIVRLHDVLH--S-----------------------------DKKLTLVFEFCDQ-DLKKYFD--SCNG----------------------------------------------------------------------------------------------------DLDPEIVKSFLFQLLKGLGFCHSR--------NVLHRDLKPQNLLINR---NGELKLADFGLARAF------GIPVRCYSA---EVVTLWYRPPDVLF-----GAKL---YSTSIDMWSAGCIFAELANAGR----------PL---------------FPGN-----DVDDQLKRIFRLLG----TPTEEQWPSMTKLPDYKPYPMYPAT--TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF---
--LQFGKTLGAGAFGKVVEATAFG--LGKEDAVLKVAVKMLK-S-T-AH-ADEKEALM-S-ELKIMSHLGQHENIVNLLGACT--H-----------------------------GGPVLVITEYCCYGDLLNFLR----RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASK--------NCIHRDVAARNVLLTN---GHVAKIGDFGLARDI---M--N--DSNYIVKGNARLPVKWMAPESIF------DCV---YTVQSDVWSYGILLWEIFSLGL----------NP---------------YPGI-L---VNSKFYKLVKDGYQ----MAQPAFAP------------------------------KNIYSIMQACWALEPTHRPTFQQICSFL-----
-F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-E-A-TS-PKANKEIL-D-EAYVMASV-DNPHVCRLLGICL--------------------------------TSTVQLITQLMPFGCLLDYVR----EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDR--------RLVHRDLAARNVLVKT---PQHVKITDFGLAKLL---G--A--EEKEYHAEGGKVPIKWMALESIL------HRI---YTHQSDVWSYGVTVWELMTFGS----------KP---------------YDGI-----PASEISSILEKGER----LPQPPICT------------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF-
-F-KEIELIGSGGFGQVFKAKHR-------IDGKTYVIKRVKYN-N-EKAER---------EVKALAKL-DHVNIVHYNGCWD--GFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEK-RRGE----------------------------------------------------------------------------------------------------KLDKVLALELFEQITKGVDYIHSK--------KLIHRDLKPSNIFLVD---TKQVKIGDFGLVTS-------LKNDGKRTR---SKGTLRYMSPEQIS------SQD---YGKEVDLYALGLILAELLH-VC---------DTA---------------FET------------SKFFTDLR----DGIISDIFDK-----------------------------KEKTLLQKLLSKKPEDRPNTSEILR----TLT
-L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-S-D-AT-EKDLSDLI-S-EMEMMKMIGKHKNIINLLGACT--Q-----------------------------DGPLYVIVEYASKGNLREYLQ----ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK--------KCIHRDLAARNVLVTE---DNVMKIADFGLARDI---H--H--IDYYKKTTNGRLPVKWMAPEALF------DRI---YTHQSDVWSFGVLLWEIFTLGG----------SP---------------YPGV-----PVEELFKLLKEGHR----MDKPSNCT------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL-----
--LKLEKKLGAGQFGEVWMATYN--------KHTKVAVKTMK-P-G-SM-SV--EAFL-A-EANVMKTL-QHDKLVKLHAVVT--------------------------------KEPIYIITEFMAKGSLLDFLK----SD-------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQR--------NYIHRDLRAANILVSA---SLVCKIADFGLARVI------E--DNEYTAREGAKFPIKWTAPEAIN------FGS---FTIKSDVWSFGILLMEIVTYGR----------IP---------------YPGM-----SNPEVIRALERGYR----MPRPENCP------------------------------EELYNIMMRCWKNRPEERPTFEYIQSV--L---
--ITMSRELGQGSFGMVYEGVAKG--VVKDEPETRVAIKTVN-E-A-AS-MRERIEFL-N-EASVMKEF-NCHHVVRLLGVVS--Q-----------------------------GQPTLVIMELMTRGDLKSYLR----SLRPEM-----------------------------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNAN--------KFVHRDLAARNCMVAE---DFTVKIGDFGMTRDI---Y--E--TDYYRKGGKGLLPVRWMSPESLK------DGV---FTTYSDVWSFGVVLWEIATLAE----------QP---------------YQGL-----SNEQVLRFVMEGGL----LDKPDNCP------------------------------DMLFELMRMCWQYNPKMRPSFLEIISS--I---
--ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVN-E-S-AS-LRERIEFL-N-EASVMKGF-TCHHVVRLLGVVS--K-----------------------------GQPTLVVMELMAHGDLKSYLR----SLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAK--------KFVHRDLAARNCMVAH---DFTVKIGDFGMTRDI---Y--E--TDYYRKGGKGLLPVRWMAPESLK------DGV---FTTSSDMWSFGVVLWEITSLAE----------QP---------------YQGL-----SNEQVLKFVMDGGY----LDQPDNCP------------------------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL-----
--LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKLQ-H-S-TE--EHLRDFE-R-EIEILKSL-QHDNIVKYKGVCYSAG-----------------------------RRNLKLIMEYLPYGSLRDYLQ----KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTK--------RYIHRDLATRNILVEN---ENRVKIGDFGLTKVL--PQ--D--KEYYKVKEPGESPIFWYAPESLT------ESK---FSVASDVWSFGVVLYELFTYIE----------KSKSPPAEFMRMIGNDKQGQM-----IVFHLIELLKNNGR----LPRPDGCP------------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV-
--LSFGKTLGAGAFGKVVEATAYG--LIKSDAAMTVAVKMLK-P-S-AH-LTEREALM-S-ELKVLSYLGNHMNIVNLLGACT--I-----------------------------GGPTLVITEYCCYGDLLNFLR----RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASK--------NCIHRDLAARNILLTH---GRITKICDFGLARDI---K--N--DSNYVVKGNARLPVKWMAPESIF------NCV---YTFESDVWSYGIFLWELFSLGS----------SP---------------YPGM-P---VDSKFYKMIKEGFR----MLSPEHAP------------------------------AEMYDIMKTCWDADPLKRPTFKQIVQL--I---
--LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-Q-G-SM-SP--DAFL-A-EANLMKQL-QHQRLVRLYAVVT--------------------------------QEPIYIITEYMENGSLVDFLK----TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEER--------NYIHRDLRAANILVSD---TLSCKIADFGLARLI------E--DNEYTAREGAKFPIKWTAPEAIN------YGT---FTIKSDVWSFGILLTEIVTHGR----------IP---------------YPGM-----TNPEVIQNLERGYR----MVRPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L---
--IKLVKRLGAGQFGEVWMGYYN--------NSTKVAVKTLK-P-G-TM-SV--QAFL-E-EANLMKTL-QHDKLVRLYAVVT--R-----------------------------EEPIYIITEYMAKGSLLDFLK----SD-------------------------------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERK--------NYIHRDLRAANVLVSE---SLMCKIADFGLARVI------E--DNEYTAREGAKFPIKWTAPEAIN------FGC---FTIKSDVWSFGILLYEIVTYGK----------IP---------------YPGR-----TNADVMTALSQGYR----MPRVENCP------------------------------DELYDIMKMCWKEKAEERPTFDYLQSV--L---
--YQNLSPVGSGAYGSVCAAFDT-------KTGLRVAVKKLSRP-F-QSIIH--AKRTYR-ELRLLKHM-KHENVIGLLDVFT--PARS-----------------------LEEFNDVYLVTHLMGA-DLNNIVK----CQ----------------------------------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSA--------DIIHRDLKPSNLAVNE---DCELKILDFGLAR---------HTDDEMTG---YVATRWYRAPEIML-----NWMH---YNQTVDIWSVGCIMAELLT-GR----------TL---------------FPGT-----DHIDQLKLILRLVG----TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF---
IV--LKWELGEGAFGKVFLAECHN--LLPEQDKMLVAVKALK-E-A-SE-SA-RQDFQ-R-EAELLTML-QHQHIVRFFGVCT--E-----------------------------GRPLLMVFEYMRHGDLNRFLR----SHGPDAKL------------------------------------------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGL--------HFVHRDLATRNCLVGQ---GLVVKIGDFGMSRDI---Y--S--TDYYRVGGRTMLPIRWMPPESIL------YRK---FTTESDVWSFGVVLWEIFTYGK----------QP---------------WYQL-----SNTEAIDCITQGRE----LERPRACP------------------------------PEVYAIMRGCWQREPQQRHSIKDVHARL-----
-L-VLGRVLGSGAFGKVVEGTAYG--LSRSQPVMKVAVKMLK-P-T-AR-SSEKQALM-S-ELKIMTHLGPHLNIVNLLGACT--K-----------------------------SGPIYIITEYCFYGDLVNYLH----KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASK--------NCVHRDLAARNVLLAQ---GKIVKICDFGLARDI---M--H--DSNYVSKGSTFLPVKWMAPESIF------DNL---YTTLSDVWSYGILLWEIFSLGG----------TP---------------YPGM-M---VDSTFYNKIKSGYR----MAKPDHAT------------------------------SEVYEIMVKCWNSEPEKRPSFYHLSE---IV--
-L-VLGRTLGSGAFGQVVEATAHG--LSHSQATMKVAVKMLK-S-T-AR-SSEKQALM-S-ELKIMSHLGPHLNVVNLLGACT--K-----------------------------GGPIYIITEYCRYGDLVDYLH----RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASK--------NCVHRDLAARNVLICE---GKLVKICDFGLARDI---M--R--DSNYISKGSTFLPLKWMAPESIF------NSL---YTTLSDVWSFGILLWEIFTLGG----------TP---------------YPEL-P---MNEQFYNAIKRGYR----MAQPAHAS------------------------------DEIYEIMQKCWEEKFEIRPPFSQLVL---LL--
-L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-E-N-AS-PSELRDLL-S-EFNVLKQV-NHPHVIKLYGACS--Q-----------------------------DGPLLLIVEYAKYGSLRGFLR----ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM--------KLVHRDLAARNILVAE---GRKMKISDFGLSRDV---Y--E--EDSYVKRSQGRIPVKWMAIESLF------DHI---YTTQSDVWSFGVLLWEIVTLGG----------NP---------------YPGI-----PPERLFNLLKTGHR----MERPDNCS------------------------------EEMYRLMLQCWKQEPDKRPVFADISKDL-----
--YDIERTLGKGNFAVVKLARHR-------VTKTQVAIKIIDKT-R-LDSSN--LEKIYR-EVQLMKLL-NHPHIIKLYQVME--T-----------------------------KDMLYIVTEFAKNGEMFDYLT---SNG----------------------------------------------------------------------------------------------------HLSENEARKKFWQILSAVEYCHDH--------HIVHRDLKTENLLLDG---NMDIKLADFGFGNF-------YKSGEPLST---WCGSPPYAAPEVFE-----GKEY---EGPQLDIWSLGVVLYVLVC-GS----------LP---------------FDGP--------NLPTLRQRVLE----GRFRIPFFMS----------------------------QDCESLIRRMLVVDPARRITIAQIRQHRWM---
-L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-P-G-TM-SP--EAFL-Q-EAQVMKKL-RHEKLVQLYAVVS--------------------------------EEPIYIVTEYMSKGSLLDFLK----GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERM--------NYVHRDLRAANILVGE---NLVCKVADFGLARLI------E--DNEYTARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILLTELTTKGR----------VP---------------YPGM-----VNREVLDQVERGYR----MPCPPECP------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L---
IV--LQESIGKGRFGEVWRGKWR-------GEE--VAVKIFSSR-E-ERSWF--REA----EIYQTVML-RHENILGFIAADN--KDN-------------------------GTWTQLWLVSDYHEHGSLFDYLN----RY----------------------------------------------------------------------------------------------------TVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKK---NGTCCIADLGLAVRHDS--ATDTIDIAPNH---RVGTKRYMAPEVLDDSINMKHFE---SFKRADIYAMGLVFWEIAR-RCSIGGIHEDYQLP---------------YYDLVPSDPSVEEMRKVVCEQKL----RPNIPNRWQSCEAL------------------------RVMAKIMRECWYANGAARLTALRIKK----TL-
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