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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC GRK1 203
CMGC CDK2 4
TK EGFR 712
AGC GRK6 186
TKL MAP3K7 36
TK RET 724
FLDF----RVLGKGGFGEVSACQMK-----ATGKLYACKKLNKKRLKKRK--GYQGAMVEKKILMKVHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENP--------------------------GFPEPRALFYTAQIICGLEHLHQRR---IVYRDLKPENVLLDNDG-NVRISDLGLAVEL-LDGQSKTKG---YAGTPGFMAPELLQ-GEEYDFSVDYFALGVTLYEMIA-ARGPFRAR--GEKVENKELKHRIISEPVKYPDKFS--------------------------QASKDFCEALLEKDPEKRLG-----FRD-------ETCDKLRAHPLF
----FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKIRLDTETEGV--PSTAIR-EISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDA--SALT--------------------------GIPLPLIKSYLFQLLQGLAFCHSHR---VLHRDLKPQNLLINTEG-AIKLADFGLARAF-GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD---SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF------------
---F-KKIKVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELR-EATS-PKANKEIL-D-EAYVMASVDNPHVCRLLGICL-TSTVQLITQLMPFGCLLDYVR-----EH-----------------------K-DNIGSQYLLNWCVQIAKGMNYLEDRR---LVHRDLAARNVLVKTPQ-HVKITDFGLAKLLGA--EEKEYHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGI---PASEISSILEKGERLPQPPICT----------------------------IDVYMIMVKCWMIDADSRPK-----FRELI----IEF----------
---F-RQYRVLGKGGFGEVCACQVR-----ATGKMYACKKLEKKRIKKRK--GEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYH--MGQA--------------------------GFPEARAVFYAAEICCGLEDLHRER---IVYRDLKPENILLDDHG-HIRISDLGLAVH--VPEGQTIKG---RVGTVGYMAPEVVK-NERYTFSPDWWALGCLLYEMIA-GQSPFQQR---KKKIKREEVERLVK-EVPEEYSER--FS----------------------PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF------------
----IEVEEVVGRGAFGVVCKAKWR-------AKDVAIKQIE----S-ESERKAFI-V-ELRQLSRVNHPNIVKLYGACL--NPVCLVMEYAEGGSLYNVLH-----GA----------------------EPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDI-------QTHMTNNKGSAAWMAPEVFE-GSNYSEKCDVFSWGIILWEVITR-RKPFDEIGG-PAFRIMWAVHNGTRPPLIKNLP----------------------------KPIESLMTRCWSKDPSQRPS-----MEEIVKI--M------------
---L-VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-ENAS-PSELRDLL-S-EFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLR-----ESRKVGPGYLGSGGSRNSSSLDHPDE-RALTMGDLISFAWQISQGMQYLAEMK---LVHRDLAARNILVAEGR-KMKISDFGLSRDVYE--EDSYVKRSQGRIPVKWMAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI---PPERLFNLLKTGHRMERPDNCS----------------------------EEMYRLMLQCWKQEPDKRPV-----FADISKDL--------------
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