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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC GRK6 203
AGC AKT1 150
Other AURKA 133
Other AURKB 77
Other AURKC 43
CAMK CAMK2A 13
CAMK CAMK4 46
CMGC CDC2L5 705
CMGC CDK2 4
CMGC CDK3 4
CMGC CDKL2 4
CMGC CDKL3 4
CMGC CDKL5 13
CAMK CHEK1 9
CAMK CHEK2 220
AGC CIT 97
CAMK DAPK1 13
CAMK DCLK3 356
AGC GRK1 190
AGC GRK4 187
AGC GRK7 191
TK JAK3 822
STE MAP3K1 1242
STE MAP3K2 356
STE MAP3K3 362
STE MAP3K4 1342
CMGC MAPK10 64
CMGC MAPK12 27
CAMK MAPKAPK2 64
AGC MAST1 374
AGC PDPK1 82
CAMK PIM3 40
AGC PKN2 657
AGC PRKACA 44
AGC PRKACB 44
AGC PRKCD 349
AGC PRKCQ 380
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
AGC PRKG1 375
AGC PRKG2 453
AGC PRKX 49
AGC ROCK1 76
AGC ROCK2 92
CAMK STK17A 61
CAMK STK17B 33
STE STK24 24
STE STK25 20
Other STK36 4
AGC STK38 89
AGC STK38L 90
Other TTK 525
STE YSK4 1162
---F-RQYRVLGKGGFGEVCACQVR----ATGKMYACKKLEKKR-IK-KRK-GE-AMAL-----NEKQILEKV-N----SRFVVSLAYAYE--T----------KDALCLVLTLMNGG-DLKFHIYH--MGQA--GFPEARAVFYAAEICCGLEDLHR-ERIVYRDLKPENILLD-DHGHI----RISDLGLAVH------------------------------------VPEGQTIKG---RVGTVGYMAPEVVK-----------NERYTFSPDWWALGCLLYEMIA-GQSP-------------FQQR--KKKIKREEVERLVK-EVPEEYSER--FS-----------------------------------PQARSLCSQLLCKDPAE--RLGCRGGSAR-EVKEHPLF------------------
---F-EYLKLLGKGTFGKVILVKEK----ATGRYYAMKILKKEV-IV-AKD-EV-AHTL-----TENRVLQNS-R----HPFLTALKYSFQ--T----------HDRLCFVMEYANGG-ELFFHLS----RER--VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD-KDGHI----KITDFGLCKEG-----------------------------------IKDGATMKT---FCGTPEYLAPEVLE-----------DNDYGRAVDWWGLGVVMYEMMC-GRLP-------------FYNQ-----DHEKLFELILMEEIRFPRTLG---------------------------------------PEAKSLLSGLLKKDPKQ--RLGGGSEDAK-EIMQHRFF------------------
----FEIGRPLGKGKFGNVYLAREK----QSKFILALKVLFKAQLEK-AGV-EH-QLRR------EVEIQSHL-R----HPNILRLYGYFH--D----------ATRVYLILEYAPLG-TVYRELQ----KLS--KFDEQRTATYITELANALSYCHS-KRVIHRDIKPENLLLG-SAGEL----KIADFGWSV-------------------------------------HAPSSRRTT---LCGTLDYLPPEMIE-----------GRMHDEKVDLWSLGVLCYEFLV-GKPP-------------FEAN-----TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQ--RPM-----LR-EVLEHPWI------------------
----FEIGRPLGKGKFGNVYLAREK----KSHFIVALKVLFKSQ-IE-KEG-VE-HQLR-----REIEIQAHL-H----HPNILRLYNYFY--D----------RRRIYLILEYAPRG-ELYKELQ----KSC--TFDEQRTATIMEELADALMYCHG-KKVIHRDIKPENLLLG-LKGEL----KIADFGWSV-------------------------------------HAPSLRRKT---MCGTLDYLPPEMIE-----------GRMHNEKVDLWCIGVLCYELLV-GNPP-------------FESA-----SHNETYRRIVKVDLKFPASVP---------------------------------------MGAQDLISKLLRHNPSE--RLP-----LA-QVSAHPWV------------------
----FEIGRPLGKGKFGNVYLARLK----ESHFIVALKVLFKSQ-IE-KEG-LE-HQLR-----REIEIQAHL-Q----HPNILRLYNYFH--D----------ARRVYLILEYAPRG-ELYKELQ----KSE--KLDEQRTATIIEELADALTYCHD-KKVIHRDIKPENLLLG-FRGEV----KIADFGWSV-------------------------------------HTPSLRRKT---MCGTLDYLPPEMIE-----------GRTYDEKVDLWCIGVLCYELLV-GYPP-------------FESA-----SHSETYRRILKVDVRFPLSMP---------------------------------------LGARDLISRLLRYQPLE--RLP-----LA-QILKHPWV------------------
----YQLFEELGKGAFSVVRRCVKV----LAGQEYAAKIINTKK-LS-ARD-HQ-KLER------EARICRLL-K----HPNIVRLHDSIS--E----------EGHHYLIFDLVTGG-ELFEDIV----ARE--YYSEADASHCIQQILEAVLHCHQ-MGVVHRDLKPENLLLA-SKLKGA-AVKLADFGLAIEV-----------------------------------EGEQQAWFG---FAGTPGYLSPEVLR-----------KDPYGKPVDLWACGVILYILLV-GYPP-------------FWDE-----DQHRLYQQIKAGAYDFPSPEWDTVT-----------------------------------PEAKDLINKMLTINPSK--RIT-----AA-EALKHPWI------------------
----FEVESELGRGATSIVYRCKQK----GTQKPYALKVLKKTV-DK-KIV-R-----T------EIGVLLRL-S----HPNIIKLKEIFE--T----------PTEISLVLELVTGG-ELFDRIV----EKG--YYSERDAADAVKQILEAVAYLHE-NGIVHRDLKPENLLYA-T-PAPDAPLKIADFGLSKI------------------------------------VEHQVLMKT---VCGTPGYCAPEILR-----------GCAYGPEVDMWSVGIITYILLC-GFEP-------------FYDE----RGDQFMFRRILNCEYYFISPWWDEVS-----------------------------------LNAKDLVRKLIVLDPKK--RLT-----TF-QALQHPWV------------------
---F-DIIGIIGEGTYGQVYKARDK----DTGEMVALKKVRLDN-EK-EGF-PI-TAIR------EIKILRQL-T----HQSIINMKEIVT--DKEDALDFKKDKGAFYLVFEYMDH--DLMGLLE---SGLV--HFNENHIKSFMRQLMEGLDYCHK-KNFLHRDIKCSNILLN-NRGQI----KLADFGLARLY----------------------------------SSEESRPYTN---KVITLWYRPPELLL----------GEERYTPAIDVWSCGCILGELFT-KKPI-------------FQAN--QELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQY------------RRKLREEFVFIPAAALDLFDYMLALDPSK--RCT-----AE-QALQCEF-L-----------------
----FQKVEKIGEGTYGVVYKARNK----LTGEVVALKKIRLDT-ET-EGV-PS-TAIR------EISLLKEL-N----HPNIVKLLDVIH--T----------ENKLYLVFEFLHQ--DLKKFMDA--SALT--GIPLPLIKSYLFQLLQGLAFCHS-HRVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF-----------------------------------GVPVRTYTH---EVVTLWYRAPEILL----------GCKYYSTAVDIWSLGCIFAEMVT-RRAL-------------FPGD--SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RIS-----AK-AALAHPFF------------------
----FQKVEKIGEGTYGVVYKAKNR----ETGQLVALKKIRLDL-EM-EGV-PS-TAIR------EISLLKEL-K----HPNIVRLLDVVH--N----------ERKLYLVFEFLSQ--DLKKYMDS--TPGS--ELPLHLIKSYLFQLLQGVSFCHS-HRVIHRDLKPQNLLIN-ELGAI----KLADFGLARAF-----------------------------------GVPLRTYTH---EVVTLWYRAPEILL----------GSKFYTTAVDIWSIGCIFAEMVT-RKAL-------------FPGD--SEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR-------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQ--RIT-----AK-TALAHPYF------------------
----YENLGLVGEGSYGMVMKCRNK----DTGRIVAIKKFLESD-DD-KMV-KK-IAMR------EIKLLKQL-R----HENLVNLLEVCK--K----------KKRWYLVFEFVDHT-ILDDLEL----FPN--GLDYQVVQKYLFQIINGIGFCHS-HNIIHRDIKPENILVS-QSGVV----KLCDFGFARTL-----------------------------------AAPGEVYTD---YVATRWYRAPELLV----------GDVKYGKAVDVWAIGCLVTEMFM-GEPL-------------FPGD--SDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKE-----------REPLERRYPKLSEVVIDLAKKCLHIDPDK--RPF-----CA-ELLHHDFF------------------
----YETLGKVGEGSYGTVMKCKHK----NTGQIVAIKIFYERP-EQ-SVN-K--IAMR------EIKFLKQF-H----HENLVNLIEVFR--Q----------KKKIHLVFEFIDHT-VLDELQH----YCH--GLESKRLRKYLFQILRAIDYLHS-NNIIHRDIKPENILVS-QSGIT----KLCDFGFARTL-----------------------------------AAPGDIYTD---YVATRWYRAPELVL----------KDTSYGKPVDIWALGCMIIEMAT-GNPY-------------LPSS--SDLDLLHKIVLKVGN-LSPHLQNIFSKSPIFAGVVLPQVQ----------HPKNARKKYPKLNGLLADIVHACLQIDPAD--RIS-----SS-DLLHHEYF------------------
----FEILGVVGEGAYGVVLKCRHK----ETHEIVAIKKFKDSE-EN-EEV-KE-TTLR------ELKMLRTL-K----QENIVELKEAFR--R----------RGKLYLVFEYVEK--NMLELLE---EMPN--GVPPEKVKSYIYQLIKAIHWCHK-NDIVHRDIKPENLLIS-HNDVL----KLCDFGFARNL----------------------------------SEGNNANYTE---YVATRWYRSPELLL-----------GAPYGKSVDMWSVGCILGELSD-GQPL-------------FPGE--SEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNH----------PQSLERRYLGILNSVLLDLMKNLLKLDPAD--RYL-----TE-QCLNHPTF------------------
---W-DLVQTLGEGAYGEVQLAVNR----VTEEAVAVKIVDMKR-AV-DCP-EN-I-KK------EICINKML-N----HENVVKFYGHRR--E----------GNIQYLFLEYCSGG-ELFDRIE----PDI--GMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLLLD-ERDNL----KISDFGLATVFR---------------------------------YNNRERLLNK---MCGTLPYVAPELLK----------RREFHAEPVDVWSCGIVLTAMLA-GELP-------------WDQP----SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------SAPLALLHKILVENPSA--RIT-----IP-DIKKDRW-Y-----------------
--YI--MSKTLGSGACGEVKLAFER----KTCKKVAIKIISKRK-FA-IGS-AR-EADPALNVETEIEILKKL-N----HPCIIKIKNFF---D----------AEDYYIVLELMEGG-ELFDKVV----GNK--RLKEATCKLYFYQMLLAVQYLHE-NGIIHRDLKPENVLLS-SQEEDC-LIKITDFGHSKI------------------------------------LGETSLMRT---LCGTPTYLAPEVLVS--------VGTAGYNRAVDCWSLGVILFICLS-GYPP-------------FSEH----RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------EKALDLVKKLLVVDPKA--RFT-----TE-EALRHPWL------------------
---F-EVRSLVGCGHFAEVQVVREK----ATGDIYAMKVMKKKA-LL-AQE-QV-SFFE-----EERNILSRS-T----SPWIPQLQYAFQ--D----------KNHLYLVMEYQPGG-DLLSLLN---RYED--QLDENLIQFYLAELILAVHSVHL-MGYVHRDIKPENILVD-RTGHI----KLVDFGSAAKM----------------------------------NSNKMVNAKL---PIGTPDYMAPEVLTVM-----NGDGKGTYGLDCDWWSVGVIAYEMIY-GRSP-------------FAEG-----TSARTFNNIMNFQRFLKFPDDPKVS-----------------------------------SDFLDLIQSLLCG-QKE--RLK-----FE-GLCCHPFF------------------
----YDTGEELGSGQFAVVKKCREK----STGLQYAAKFIKKRR-TK-SSR-RG-VSREDI--EREVSILKEI-Q----HPNVITLHEVYE--N----------KTDVILILELVAGG-ELFDFLA----EKE--SLTEEEATEFLKQILNGVYYLHS-LQIAHFDLKPENIMLL-DRNVPKPRIKIIDFGLAHK------------------------------------IDFGNEFKN---IFGTPEFVAPEIVN-----------YEPLGLEADMWSIGVITYILLS-GASP-------------FLGD-----TKQETLANVSAVNYEFEDEYFSNTS-----------------------------------ALAKDFIRRLLVKDPKK--RMT-----IQ-DSLQHPWI------------------
----YETGRVIGDGNFAVVKECRHR----ETRQAYAMKIIDKSR-LK-GKE-DM-V-DS------EILIIQSL-S----HPNIVKLHEVYE--T----------DMEIYLILEYVQGG-DLFDAII----ESV--KFPEPDAALMIMDLCKALVHMHD-KSIVHRDLKPENLLVQ-RNEDKSTTLKLADFGLAK--------------------------------------HVVRPIFT---VCGTPTYVAPEILS-----------EKGYGLEVDMWAAGVILYILLC-GFPP-------------FRSP---ERDQDELFNIIQLGHFEFLPPYWDNIS-----------------------------------DAAKDLVSRLLVVDPKK--RYT-----AH-QVLQHPWI------------------
FLDF----RVLGKGGFGEVSACQMK----ATGKLYACKKLNKKR-LK-KRK-GY-QGAM-----VEKKILMKV-H----SRFIVSLAYAFE--T----------KADLCLVMTIMNGG-DIRYHIYNVNEENP--GFPEPRALFYTAQIICGLEHLHQ-RRIVYRDLKPENVLLD-NDGNV----RISDLGLAVEL-----------------------------------LDGQSKTKG---YAGTPGFMAPELLQ-----------GEEYDFSVDYFALGVTLYEMIA-ARGP-------------FRAR-GEKVENKELKHRIISEPVKYPDKFS---------------------------------------QASKDFCEALLEKDPEK--RLG-----FR-D-------ETCDKLRAHPLF------
--FR--HYRVLGKGGFGEVCACQVR----ATGKMYACKKLQKKR-IK-KRK-GE-AMAL-----NEKRILEKV-Q----SRFVVSLAYAYE--T----------KDALCLVLTIMNGG-DLKFHIYN--LGNP--GFDEQRAVFYAAELCCGLEDLQR-ERIVYRDLKPENILLD-DRGHI----RISDLGLATE------------------------------------IPEGQRVRG---RVGTVGYMAPEVVN-----------NEKYTFSPDWWGLGCLIYEMIQ-GHSP-------------FKKY--KEKVKWEEVDQRIKNDTEEYSE---KFS-----------------------------------EDAKSICRMLLTKNPSK--RLGCRGEGAA-GVKQHPV-F-----------------
---F-TEFRVLGKGGFGEVCAVQVK----NTGKMYACKKLDKKR-LK-KKG-GE-KMAL-----LEKEILEKV-S----SPFIVSLAYAFE--S----------KTHLCLVMSLMNGG-DLKFHIYN--VGTR--GLDMSRVIFYSAQIACGMLHLHE-LGIVYRDMKPENVLLD-DLGNC----RLSDLGLAVE------------------------------------MKGGKPITQ---RAGTNGYMAPEILM----------EKVSYSYPVDWFAMGCSIYEMVA-GRTP-------------FKDY-KEKVSKEDLKQRTLQDEVKFQHDNF---T-----------------------------------EEAKDICRLFLAKKPEQ--RLG-----SR-E-------KSDDPR------------
---L-KYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQ-HS-GP--DQQRD-FQ-R------EIQILKAL-H----SDFIVKYRGVSYGPG----------RQSLRLVMEYLPSG-CLRDFLQ-----RHRARLDASRLLLYSSQICKGMEYLGS-RRCVHRDLAARNILVE-SEAHV----KIADFGLAKLL------------PL---------------------D--KDYYVVREPGQSPIFWYAPESLS-----------DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVP-ALCRLLELLEEGQRLPAPPACP-----------------------------------------AEVHELMKLCWAPSPQD--RPS-----FS-ALGP---QL-----------------
--WL--KGQQIGLGAFSSCYQAQDV----GTGTLMAVKQVTYVR-NT-SSE-QE-EVVEAL--REEIRMMSHL-N----HPNIIRMLGATC--E----------KSNYNLFIEWMAGG-SVAHLLS----KYG--AFKESVVINYTEQLLRGLSYLHE-NQIIHRDVKGANLLID-STGQR---LRIADFGAAARLAS-------------------------------KGTGAGEFQGQ---LLGTIAFMAPEVLR-----------GQQYGRSCDVWSVGCAIIEMAC-AKPP-------------WNAE--KHSNHLALIFKIASATTAPSIPSHLS-------------------------------------PGLRDVALRCLELQPQD--RPP-----SR-ELLKHPVF------------------
----WRLGKLLGQGAFGRVYLCYDV----DTGRELAVKQVQFDP-DS-PET-SK-EVNAL---ECEIQLLKNL-L----HERIVQYYGCLR--DP--------QEKTLSIFMEYMPGG-SIKDQLK----AYG--ALTENVTRKYTRQILEGVHYLHS-NMIVHRDIKGANILRD-STGNV----KLGDFGASKRLQ--------------------------------TICLSGTGMKS---VTGTPYWMSPEVIS-----------GEGYGRKADIWSVACTVVEMLT-EKPP-------------WAEF-----EAMAAIFKIATQPTNPKLPPHVS-------------------------------------DYTRDFLKRIFV-EAKL--RPS-----AD-ELLRHMF-V-----------------
---W-RRGKLLGQGAFGRVYLCYDV----DTGRELASKQVQFDP-DS-PET-SK-EVSAL---ECEIQLLKNL-Q----HERIVQYYGCLR--DR--------AEKTLTIFMEYMPGG-SVKDQLK----AYG--ALTESVTRKYTRQILEGMSYLHS-NMIVHRDIKGANILRD-SAGNV----KLGDFGASKRLQ--------------------------------TICMSGTGMRS---VTGTPYWMSPEVIS-----------GEGYGRKADVWSLGCTVVEMLT-EKPP-------------WAEY-----EAMAAIFKIATQPTNPQLPSHIS-------------------------------------EHGRDFLRRIFV-EARQ--RPS-----AE-ELLTHHF-A-----------------
---W-QRGNKIGEGQYGKVYTCISV----DTGELMAMKEIRFQP-ND-HKT-IK-ETAD------ELKIFEGI-K----HPNLVRYFGVEL--H----------REEMYIFMEYCDEG-TLEEVS------RL--GLQEHVIRLYSKQITIAINVLHE-HGIVHRDIKGANIFLT-SSGLI----KLGDFGCSVKLKN-------------------------------NAQTMPGEVNS---TLGTAAYMAPEVITR--------AKGEGHGRAADIWSLGCVVIEMVT-GKRP-------------WHEY---EHNFQIMYKVGMGHKPPIPERLS---------------------------------------PEGKDFLSHCLESDPKM--RWT-----AS-QLLDHSFV------------------
----YQNLKPIGSGAQGIVCAAYDA----VLDRNVAIKKLSRPF-QN-QTH-AK-RAYR------ELVLMKCV-N----HKNIISLLNVFT--PQKT----LEEFQDVYLVMELMDA--NLCQVIQ------M--ELDHERMSYLLYQMLCGIKHLHS-AGIIHRDLKPSNIVVK-SDCTL----KILDFGLART------------------------------------AGTSFMMTP---YVVTRYYRAPEVIL-----------GMGYKENVDIWSVGCIMGEMVR-HKIL-------------FPGR--DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAK--RIS-----VD-DALQHPYI------------------
----YRDLQPVGSGAYGAVCSAVDG----RTGAKVAIKKLYRPF-QS-ELF-AK-RAYR------ELRLLKHM-R----HENVIGLLDVFT--PDET----LDDFTDFYLVMPFMGT--DLGKLMK-----HE--KLGEDRIQFLVYQMLKGLRYIHA-AGIIHRDLKPGNLAVN-EDCEL----KILDFGLAR--------------------------------------QADSEMTG---YVVTRWYRAPEVIL----------NWMRYTQTVDIWSVGCIMAEMIT-GKTL-------------FKGS--DHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELE-----------KKDFASILTNASPLAVNLLEKMLVLDAEQ--RVT-----AG-EALAHPYF------------------
-KVT---SQVLGLGINGKVLQIFNK----RTQEKFALKMLQDCP-KA-R---------R------EVELHWRASQ----CPHIVRIVDVYE--NLY------AGRKCLLIVMECLDGG-ELFSRIQD--RGDQ--AFTEREASEIMKSIGEAIQYLHS-INIAHRDVKPENLLYT-SKRPNA-ILKLTDFGFAKE------------------------------------TTSHNSLTT---PCYTPYYVAPEVLG-----------PEKYDKSCDMWSLGVIMYILLC-GYPP-------------FYSN-HGLAISPGMKTRIRMGQYEFPNPEWSEVS-----------------------------------EEVKMLIRNLLKTEPTQ--RMT-----IT-EFMNHPWI------------------
--FD--TIKLISNGAYGAVYLVRHR----DTRQRFAMKKINKQN-LILRNQ-IQ-QAFV------ERDILTFA-E----NPFVVGMFCSFE--T----------RRHLCMVMEYVEGG-DCATLLK----NIG--ALPVEMARMYFAETVLALEYLHN-YGIVHRDLKPDNLLIT-SMGHI----KLTDFGLSKMGLMSLTTN--------------------LYEGHIEKDAREFLDKQ---VCGTPEYIAPEVIL-----------RQGYGKPVDWWAMGIILYEFLV-GCVP-------------FFGD-----TPEELFGQVISDDILWPEGDE-ALP-----------------------------------TEAQLLISSLLQTNPLV--RLGA--GGAF-EVKQHSFF------------------
---F-KFGKILGEGSFSTVVLAREL----ATSREYAIKILEKRH-II-KEN-KVPYVTR------ERDVMSRL-D----HPFFVKLYFTFQ--D----------DEKLYFGLSYAKNG-ELLKYIR----KIG--SFDETCTRFYTAEIVSALEYLHG-KGIIHRDLKPENILLN-EDMHI----QITDFGTAKVLS---------------------------------PESKQARANS---FVGTAQYVSPELLT-----------EKSACKSSDLWALGCIIYQLVA-GLPP-------------FRAG-----NEYLIFQKIIKLEYDFPEKFF---------------------------------------PKARDLVEKLLVLDATK--RLG-----CE-EM------EGYGPLKAHPF-------
----YQVGAVLGSGGFGTVYAGSRI----ADGLPVAVKHVVKER-VT-EWG-SL-GGATV---PLEVVLLRKV-GAAGGARGVIRLLDWFE--R----------PDGFLLVLERPEPAQDLFDFIT----ERG--ALDEPLARRFFAQVLAAVRHCHS-CGVVHRDIKDENLLVDLRSGEL----KLIDFGSGA-------------------------------------LLKDTVYTD---FDGTRVYSPPEWIR----------YHRYHGRSATVWSLGVLLYDMVC-GDIP-------------FEQD-----------EEILRGRLLFRRRVS---------------------------------------PECQQLIRWCLSLRPSE--RPS-----LD-QIAAHPWM------------------
--FR--CCAVLGRGHFGKVLLAEYK----NTNEMFAIKALKKGD-IV-ARD-EV-DSLM-----CEKRIFETV-NS-VRHPFLVNLFACFQ--T----------KEHVCFVMEYAAGG-DLMMHIH-----TD--VFSEPRAVFYAACVVLGLQYLHE-HKIVYRDLKLDNLLLD-TEGFV----KIADFGLCKEG-----------------------------------MGYGDRTST---FCGTPEFLAPEVLT-----------ETSYTRAVDWWGLGVLIYEMLV-GESP-------------FPGD-----DEEEVFDSIVNDEVRYPRFLS---------------------------------------TEAISIMRRLLRRNPER--RLGASEKDAE-DVKKHPFF------------------
---F-ERIKTLGTGSFGRVMLVKHK----ETGNHYAMKILDKQK-VV-KLK-QI-EHTL-----NEKRILQAV-N----FPFLVKLEFSFK--D----------NSNLYMVMEYVPGG-EMFSHLR----RIG--RFSEPHARFYAAQIVLTFEYLHS-LDLIYRDLKPENLLID-QQGYI----QVTDFGFAK--------------------------------------RVKGRTWT---LCGTPEYLAPEIIL-----------SKGYNKAVDWWALGVLIYEMAA-GYPP-------------FFAD-----QPIQIYEKIVSGKVRFPSHFS---------------------------------------SDLKDLLRNLLQVDLTK--RFGNLKNGVN-DIKNHKWF------------------
---F-ERKKTLGTGSFGRVMLVKHK----ATEQYYAMKILDKQK-VV-KLK-QI-EHTL-----NEKRILQAV-N----FPFLVRLEYAFK--D----------NSNLYMVMEYVPGG-EMFSHLR----RIG--RFSEPHARFYAAQIVLTFEYLHS-LDLIYRDLKPENLLID-HQGYI----QVTDFGFAK--------------------------------------RVKGRTWT---LCGTPEYLAPEIIL-----------SKGYNKAVDWWALGVLIYEMAA-GYPP-------------FFAD-----QPIQIYEKIVSGKVRFPSHFS---------------------------------------SDLKDLLRNLLQVDLTK--RFGNLKNGVS-DIKTHKWF------------------
--FI--FHKVLGKGSFGKVLLGELK----GRGEYFAIKALKKDV-VL-IDD-DV-ECTM-----VEKRVLTLAAE----NPFLTHLICTFQ--T----------KDHLFFVMEFLNGG-DLMYHIQ----DKG--RFELYRATFYAAEIMCGLQFLHS-KGIIYRDLKLDNVLLD-RDGHI----KIADFGMCKEN-----------------------------------IFGESRAST---FCGTPDYIAPEILQ-----------GLKYTFSVDWWSFGVLLYEMLI-GQSP-------------FHGD-----DEDELFESIRVDTPHYPRWIT---------------------------------------KESKDILEKLFEREPTK--RLG----VTG-NIKIHPFF------------------
--FI--LHKMLGKGSFGKVFLAEFK----KTNQFFAIKALKKDV-VL-MDD-DV-ECTM-----VEKRVLSLAWE----HPFLTHMFCTFQ--T----------KENLFFVMEYLNGG-DLMYHIQ----SCH--KFDLSRATFYAAEIILGLQFLHS-KGIVYRDLKLDNILLD-KDGHI----KIADFGMCKEN-----------------------------------MLGDAKTNT---FCGTPDYIAPEILL-----------GQKYNHSVDWWSFGVLLYEMLI-GQSP-------------FHGQ-----DEEELFHSIRMDNPFYPRWLE---------------------------------------KEAKDLLVKLFVREPEK--RLG-----VRGDIRQHPLF------------------
--PD----EVLGSGQFGIVYGGKHR----KTGRDVAIKIIDKLR-FP-TKQ-ES-QLRN------EVAILQNL-H----HPGVVNLECMFE--T----------PERVFVVMEKLHGD-MLEMILS---SEKG--RLPEHITKFLITQILVALRHLHF-KNIVHCDLKPENVLLA-SADPFP-QVKLCDFGFARI------------------------------------IGEKSFRRS---VVGTPAYLAPEVLR-----------NKGYNRSLDMWSVGVIIYVSLS-GTFP-------------FNED-------EDIHDQIQNAAFMYPPNPWKEIS-----------------------------------HEAIDLINNLLQVKMRK--RYS-----VD-KTLSHPWL------------------
--PD----EVLGSGQFGVVYGGKHR----KTGRDVAVKVIDKLR-FP-TKQ-ES-QLRN------EVAILQSL-R----HPGIVNLECMFE--T----------PEKVFVVMEKLHGD-MLEMILS---SEKG--RLPERLTKFLITQILVALRHLHF-KNIVHCDLKPENVLLA-SADPFP-QVKLCDFGFARI------------------------------------IGEKSFRRS---VVGTPAYLAPEVLL-----------NQGYNRSLDMWSVGVIMYVSLS-GTFP-------------FNED-------EDINDQIQNAAFMYPASPWSHIS-----------------------------------AGAIDLINNLLQVKMRK--RYS-----VD-KSLSHPWL------------------
-FAD----EVLGSGQFGIVYGGKHR----KTGRDVAIKVIDKMR-FP-TKQ-ES-QLRN------EVAILQNL-H----HPGIVNLECMFE--T----------PERVFVVMEKLHGD-MLEMILS---SEKS--RLPERITKFMVTQILVALRNLHF-KNIVHCDLKPENVLLA-SAEPFP-QVKLCDFGFARI------------------------------------IGEKSFRRS---VVGTPAYLAPEVLR-----------SKGYNRSLDMWSVGVIIYVSLS-GTFP-------------FNED-------EDINDQIQNAAFMYPPNPWREIS-----------------------------------GEAIDLINNLLQVKMRK--RYS-----VD-KSLSHPWL------------------
---F-NIIDTLGVGGFGRVELVQLKS---EESKTFAMKILKKRH-IV-DTR-QQ-EHIR-----SEKQIMQGA-H----SDFIVRLYRTFK--D----------SKYLYMLMEACLGG-ELWTILR----DRG--SFEDSTTRFYTACVVEAFAYLHS-KGIIYRDLKPENLILD-HRGYA----KLVDFGFAKK------------------------------------IGFGKKTWT---FCGTPEYVAPEIIL-----------NKGHDISADYWSLGILMYELLT-GSPP-------------FSGP-----DPMKTYNIILRGIDMIEFPKKIA-------------------------------------KNAANLIKKLCRDNPSE--RLGNLKNGVK-DIQKHKWF------------------
---L-EIIATLGVGGFGRVELVKVK----NENVAFAMKCIRKKH-IV-DTK-QQ-EHVY-----SEKRILEEL-C----SPFIVKLYRTFK--D----------NKYVYMLLEACLGG-ELWSILR----DRG--SFDEPTSKFCVACVTEAFDYLHR-LGIIYRDLKPENLILD-AEGYL----KLVDFGFAKK------------------------------------IGSGQKTWT---FCGTPEYVAPEVIL-----------NKGHDFSVDFWSLGILVYELLT-GNPP-------------FSGV-----DQMMTYNLILKGIEKMDFPRKIT-------------------------------------RRPEDLIRRLCRQNPTE--RLGNLKNGIN-DIKKHRWL------------------
--FD--TLATVGTGTFGRVHLVKEK----TAKHFFALKVMSIPD-VI-RLK-QE-QHVH-----NEKSVLKEV-S----HPFLIRLFWTWH--D----------ERFLYMLMEYVPGG-ELFSYLR----NRG--RFSSTTGLFYSAEIICAIEYLHS-KEIVYRDLKPENILLD-RDGHI----KLTDFGFAKK--------------------------------------LVDRTWT---LCGTPEYLAPEVIQ-----------SKGHGRAVDWWALGILIFEMLS-GFPP-------------FFDD-----NPFGIYQKILAGKIDFPRHLD---------------------------------------FHVKDLIKKLLVVDRTR--RLGNMKNGAN-DVKHHRWF------------------
----YEVVKVIGRGAFGEVQLVRHK----STRKVYAMKLLSKFE-MI-KRS-DS-AFFW-----EERDIMAFA-N----SPWVVQLFYAFQ--D----------DRYLYMVMEYMPGG-DLVNLMS-----NY--DVPEKWARFYTAEVVLALDAIHS-MGFIHRDVKPDNMLLD-KSGHL----KLADFGTCMKM----------------------------------NKEGMVRCDT---AVGTPDYISPEVLKS-------QGGDGYYGRECDWWSVGVFLYEMLV-GDTP-------------FYAD-----SLVGTYSKIMNHKNSLTFPDDNDIS-----------------------------------KEAKNLICAFLTDREVRLGRNG-----VE-EIKRHLFF------------------
----YDVVKVIGRGAFGEVQLVRHK----ASQKVYAMKLLSKFE-MI-KRS-DS-AFFW-----EERDIMAFA-N----SPWVVQLFYAFQ--D----------DRYLYMVMEYMPGG-DLVNLMS-----NY--DVPEKWAKFYTAEVVLALDAIHS-MGLIHRDVKPDNMLLD-KHGHL----KLADFGTCMKM----------------------------------DETGMVHCDT---AVGTPDYISPEVLKS-------QGGDGFYGRECDWWSVGVFLYEMLV-GDTP-------------FYAD-----SLVGTYSKIMDHKNSLCFPEDAEIS-----------------------------------KHAKNLICAFLTDREVRLGRNG-----VE-EIRQHPFF------------------
-LCP---GRELGRGKFAVVRKCIKK----DSGKEFAAKFMRKRR-KG-QDC-RM-EIIH------EIAVLELAQD----NPWVINLHEVYE--T----------ASEMILVLEYAAGG-EIFDQCVA--DREE--AFKEKDVQRLMRQILEGVHFLHT-RDVVHLDLKPQNILLT-SESPLG-DIKIVDFGLSRI------------------------------------LKNSEELRE---IMGTPEYVAPEILS-----------YDPISMATDMWSIGVLTYVMLT-GISP-------------FLGN-----DKQETFLNISQMNLSYSEEEFDVLS-----------------------------------ESAVDFIRTLLVKKPED--RAT-----AE-ECLKHPWL------------------
-ILT---SKELGRGKFAVVRQCISK----STGQEYAAKFLKKRR-RG-QDC-RA-EILH------EIAVLELAKS----CPRVINLHEVYE--N----------TSEIILILEYAAGG-EIFSLCLP--ELAE--MVSENDVIRLIKQILEGVYYLHQ-NNIVHLDLKPQNILLS-SIYPLG-DIKIVDFGMSRK------------------------------------IGHACELRE---IMGTPEYLAPEILN-----------YDPITTATDMWNIGIIAYMLLT-HTSP-------------FVGE-----DNQETYLNISQVNVDYSEETFSSVS-----------------------------------QLATDFIQSLLVKNPEK--RPT-----AE-ICLSHSWL------------------
----FTKLEKIGKGSFGEVFKGIDN----RTQKVVAIKIIDLEE-AE-DEI-ED-IQ-Q------EITVLSQC-D----SPYVTKYYGSYL--K----------DTKLWIIMEYLGGG-SALDLLE-----PG--PLDETQIATILREILKGLDYLHS-EKKIHRDIKAANVLLS-EHGEV----KLADFGVAGQL-----------------------------------TDTQIKRNT---FVGTPFWMAPEVIK-----------QSAYDSKADIWSLGITAIELAR-GEPP-------------HSEL--HPMKVLFLIPKNNPPTLEGNYS-----------------------------------------KPLKEFVEACLNKEPSF--RPT-----AK-ELLKHKFI------------------
---F-TKLDRIGKGSFGEVYKGIDN----HTKEVVAIKIIDLEE-AE-DEI-ED-IQ-Q------EITVLSQC-D----SPYITRYFGSYL--K----------STKLWIIMEYLGGG-SALDLLK-----PG--PLEETYIATILREILKGLDYLHS-ERKIHRDIKAANVLLS-EQGDV----KLADFGVAGQL-----------------------------------TDTQIKRNT---FVGTPFWMAPEVIK-----------QSAYDFKADIWSLGITAIELAK-GEPP-------------NSDL--HPMRVLFLIPKNSPPTLEGQHS-----------------------------------------KPFKEFVEACLNKDPRF--RPT-----AK-ELLKHKFI------------------
----YHVLEMIGEGSFGRVYKGRRK----YSAQVVALKFIPKLG-RS-EKE-LR-NLQR------EIEIMRGL-R----HPNIVHMLDSFE--T----------DKEVVVVTDYAEG--ELFQILE----DDG--KLPEDQVQAIAAQLVSALYYLHS-HRILHRDMKPQNILLA-KGGGI----KLCDFGFARAM-----------------------------------STNTMVLTS---IKGTPLYMSPELVE-----------ERPYDHTADLWSVGCILYELAV-GTPP-------------FYAT-----SIFQLVSLILKDPVRWPSTIS---------------------------------------PCFKNFLQGLLTKDPRQ--RLS-----WP-DLLYHPFI------------------
---F-ESLKVIGRGAFGEVRLVQKK----DTGHVYAMKILRKAD-ML-EKE-QV-GHIR-----AERDILVEA-D----SLWVVKMFYSFQ--D----------KLNLYLIMEFLPGG-DMMTLLM----KKD--TLTEEETQFYIAETVLAIDSIHQ-LGFIHRDIKPDNLLLD-SKGHV----KLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFS---TVGTPDYIAPEVFM-----------QTGYNKLCDWWSLGVIMYEMLI-GYPP-------------FCSE-----TPQETYKKVMNWKETLTFPPEVPIS-----------------------------------EKAKDLILRFCCEW------------------------EHRIGAPGVEEIKSNSFF
---F-ESLKVIGRGAFGEVRLVQKK----DTGHIYAMKILRKSD-ML-EKE-QV-AHIR-----AERDILVEA-D----GAWVVKMFYSFQ--D----------KRNLYLIMEFLPGG-DMMTLLM----KKD--TLTEEETQFYISETVLAIDAIHQ-LGFIHRDIKPDNLLLD-AKGHV----KLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYS---TVGTPDYIAPEVFM-----------QTGYNKLCDWWSLGVIMYEMLI-GYPP-------------FCSE-----TPQETYRKVMNWKETLVFPPEVPIS-----------------------------------EKAKDLILRFCI-DSEN--RIGN--SGVE-EIKGHPFF------------------
----YSILKQIGSGGSSKVFQVLNE----KKQ-IYAIKYVNLEE-AD-NQT-LD-SYRN------EIAYLNKLQQ---HSDKIIRLYDYEI--T----------DQYIYMVMECGNI--DLNSWLK----KKK--SIDPWERKSYWKNMLEAVHTIHQ-HGIVHSDLKPANFLIV--DGML----KLIDFGIANQMQ---------------------------------PDTTSVVKDS---QVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTY-GKTP-------------FQQI----INQISKLHAIIDPNHEIEFPDIPE-------------------------------------KDLQDVLKCCLKRDPKQ--RIS-----IP-ELLAHPYV------------------
----WTKGEILGKGAYGTVYCGLTS----QGQ-LIAVKQVALDT-SN-KLA-AE-KEYRKL--QEEVDLLKAL-K----HVNIVAYLGTCL--Q----------ENTVSIFMEFVPGG-SISSIIN----RFG--PLPEMVFCKYTKQILQGVAYLHE-NCVVHRDIKGNNVMLM-PTGII----KLIDFGCARRLAWA-----------------------------GLNGTHSDMLKS---MHGTPYWMAPEVIN-----------ESGYGRKSDIWSIGCTVFEMAT-GKPP-------------LASM----DRMAAMFYIGAHRGLMPPLPDHFS-------------------------------------ENAADFVRMCLTRDQHE--RPS-----AL-QLLKHSFL------------------
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