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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC GSK3B 203
CMGC CDC2 4
STE MAP3K1 1242
AGC PRKCQ 380
--YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR----------ELQIMRKL-DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL-KLCDFGSAKQ-----LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPL-EACAHSFF
--YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIR----EISLLKEL-RHPNIVSLQDVLMQ----DSRLY--LIFEFLSM---DLKKYLDS-IPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI-KLADFGLARAF----GIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGK-MALNHPYF
WL--KGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHL-NHPNIIRMLGATCE----KSNYN--LFIEWMAGG--SVAHLLS----KYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLID-STGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLR-GQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLS------------------------PGLRDVALRCLELQPQDRPPSR-ELLKHPVF
FI--LHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTM---VEKRVLSLAWEHPFLTHMFCTFQT----KENLF--FVMEYLNGG--DLMYHIQ----SCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLD-KDGHI-KIADFGMCKEN----MLGDAKTNTFCGTPDYIAPEILL-GQKYNHSVDWWSFGVLLYEMLIGQSPFHGQ---DEEELFHSIRMDNPFYPRWLE--------------------------KEAKDLLVKLFVREPEKRLGVRGDIRQHPLF
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