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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK IGF1R 203
TK ALK 1116
TK FGFR2 481
TKL IRAK4 186
TK MET 1078
TK RET 724
AGC RPS6KA1 62
TK ZAP70 338
----ITMSRELGQGSFGMV---YEGVAKG--VVKDEPETRVAIKTVN-EAAS-MRERI-EFL-N-EASVMKEF-NCHHVVRLLGVVS-QGQPTLVIMELMTRGDLKSYLR----SLRPEM--------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE---DFTVKIGDFGMTRDI--Y-E--TDYY--RKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCP--------------DMLFELMRMCWQYNPKMRPS-----FLEIISS-I---
---I-TLIRGLGHGAFGEV---YEGQVSG--MPNDPSPLQVAVKTLP-EVCS-EQDEL-DFL-M-EALIISKF-NHQNIVRCIGVSL-QSLPRFILLELMAGGDLKSFLR----ETRP-----------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI--Y-R--ASYY--RKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCP--------------GPVYRIMTQCWQHQPEDRPN-----FAIILER-I---
----LTLGKPLGEGCFGQV---VMAEAVGIDKDKPKEAVTVAVKMLK-DDAT-EKDLS-DLV-S-EMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKGNLREYLR----ARRPPGMEY--------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE---NNVMKIADFGLARDI--N-N--IDYY--KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT--------------NELYMMMRDCWHAVPSQRPT-----FKQLVEDL----
-VGG----NKMGEGGFGVV---YKGYVN-------NTT--VAVKKLAAMVDITTE--ELKQQFDQEIKVMAKC-QHENLVELLGFSS-DGDDLCLVYVYMPNGSLLDRLSCLDGTP-------------------------PLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDE---AFTAKISDFGLARASE--KFAQTVMT--SR---IVGTTAYMAPEALR-GEITPKSDIYSFGVVLLEIIT-GLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPD-----IKKVQQ---LLQ
----VHFNEVIGRGHFGCV---YHGTLL----DNDGKKIHCAVKSLN-RITD-IGEVS-QFL-T-EGIIMKDF-SHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIR----NE-----------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDE---KFTVKVADFGLARDM--Y-D--KEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCP--------------DPLYEVMLKCWHPKAEMRPS-----FSELVSR-I---
---L-VLGKTLGEGEFGKV---VKATAFH--LKGRAGYTTVAVKMLK-ENAS-PSELR-DLL-S-EFNVLKQV-NHPHVIKLYGACS-QDGPLLLIVEYAKYGSLRGFLR----ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE---GRKMKISDFGLSRDV--Y-E--EDSY--VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCS--------------EEMYRLMLQCWKQEPDKRPV-----FADISKDL----
----FELLKVLGQGSFGKVFLVRKVTRP-------DSGHLYAMKVLKKATLKVRD--R-VRTKM-ERDILADV-NHPFVVKLHYAFQ-TEGKLYLILDFLRGGDLFTRLS---KEV-------------------------MFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDE---EGHIKLTDFGLSKEA----IDHEKKA--YS---FCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLT-GSLPFQGK---DRKETMTLILKAKLGMPQFLS------------TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV-FY-
LIAD----IELGCGNFGSV---RQGVYR-----MRKKQIDVAIKVLK-QGTE-KADTE-EMM-R-EAQIMHQL-DNPYIVRLIGVCQ--AEALMLVMEMAGGGPLHKFLV----GK-----------------------REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN---RHYAKISDFGLSKAL-GA-D--DSYY--TARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP--------------PELYALMSDCWIYKWEDRPD-----FLTVEQR-M---
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