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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK JAK3 203
CMGC CDK2 4
TK JAK1 875
TK JAK2 849
TK RET 724
L-KYISQLGKGNFGSVELCRYDP-LGDNTGALVAVKQLQ-HSGP-DQ-QRDFQ-REIQILKALHSDFIVKYRGVSYGPGRQS--LRLVMEYLPSGCLRDFLQ---RH-----------------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLD--KDYYVVREPGQSPIFWYAPESLS-DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELLEEGQRLPAPPACP----------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL-
-FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKIRLDTETEGV--PSTAIREISLLKELNHPNIVKLLDVIH--TENK--LYLVFEFLHQ-DLKKFMDASALT-------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
L-KRIRDLGEGHFGKVELCRYDP-EGDNTGEQVAVKSLK-PESG-GNHIADLK-KEIEILRNLYHENIVKYKGICT-ED-GGNGIKLIMEFLPSGSLKEYLP---KN-----------------------KNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETD--KEYYTVKDDRDSPVFWYAPECLM-QSKFYIASDVWSFGVTLHELLTYCDSDSSPMALF-LKMIGPTHGQM-TVTRLVNTLKEGKRLPCPPNCP----------------------------DEVYQLMRKCWEFQPSNRTSFQNLIE---GF-
-LKFLQQLGKGNFGSVEMCRYDP-LQDNTGEVVAVKKLQ-HSTE--EHLRDFE-REIEILKSLQHDNIVKYKGVCYSAGRRN--LKLIMEYLPYGSLRDYLQ---KH-----------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQD--KEYYKVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCP----------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
L-VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-ENAS-PSELRDLL-SEFNVLKQVNHPHVIKLYGACS--QDGP--LLLIVEYAKYGSLRGFLR---ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDV-YE--EDSYVKRSQGRIPVKWMAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGGNP---------------YPGI-PPERLFNLLKTGHRMERPDNCS----------------------------EEMYRLMLQCWKQEPDKRPVFADISKDL----
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