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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK KDR 203
TKL BRAF 456
TK BTK 402
LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKE-GATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRV---YTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTR----MRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL--
ITVGQRIGSGSFGTVYKGKWH--------GDVAVKMLNVTAPTPQQLQAFKNEVGVLRKT-RHVNILLFMGYST--KPQLAIVTQWCEGSSLYHHLHII-----------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILA--SI
LTFLKELGTGQFGVVKYGKWR------GQYDVAIKMIKE-GSMSE--DEFIEEAKVMMNL-SHEKLVQLYGVCT-KQRPIFIITEYMANGCLLNYLREM-----------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYV-LDDEYTSSVGSKFPVRWSPPEVLMYSK---FSSKSDIWAFGVLMWEIYSLGKMPYERF-TNSETAEHIAQGLR----LYRPHLASEKVYTIMYSCWHEKADERPTFKILLSN-I-
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