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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK KDR 203
TK ABL1 261
TK ABL2 288
TK BTK 402
TK DDR1 572
TK EPHA1 624
TK EPHA3 621
TK FGFR1 478
TK FLT1 827
TK FLT4 845
TK INSR 1023
TK ITK 363
TK KIT 589
TK LCK 245
TK MET 1078
TK MUSK 575
TK NTRK2 538
TK NTRK3 538
TK PDGFRA 593
TK PDGFRB 600
TK PTK2B 425
TKL RIPK1 17
TK TEK 824
TK TIE1 839
TK TXK 271
---LKLGKPLGRGAFGQVIEADAFG-----------IDKTATCRTVAVKML-KEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDI-------YKDPDY--------------VRKGDARLPLKWMAPETIFDRV--YTIQSDVWSFGVLLWEIFSLGA-SPYPGVKIDEEFCRRL----KEGTR---MR---APDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL--
---ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAVKTL-KEDTMEV--EEFLKEAAVMKEI-KHPNLVQLLGVCT-REPPFYIITEFMTYGNLLDYLREC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM--------TGDTY--------------TAHAGAKFPIKWTAPESLAYNK--FSIKSDVWAFGVLLWEIATYGM-SPYPGI-DLSQVYELL----EKDYR---ME---RPEGCPEKVYELMRACWQWNPSDRPSFAEIHQA-F-
---ITMKHKLGGGQYGEVYVGVWK----------------KYSLTVAVKTL-KEDTMEV--EEFLKEAAVMKEI-KHPNLVQLLGVCT-LEPPFYIVTEYMPYGNLLDYLREC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM--------TGDTY--------------TAHAGAKFPIKWTAPESLAYNT--FSIKSDVWAFGVLLWEIATYGM-SPYPGI-DLSQVYDLL----EKGYR---ME---QPEGCPPKVYELMRACWKWSPADRPSFAETHQA-F-
---LTFLKELGTGQFGVVKYGKWR-----------------GQYDVAIKMI-KEGSMSE--DEFIEEAKVMMNL-SHEKLVQLYGVCT-KQRPIFIITEYMANGCLLNYLREM--------------------------------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYV--------LDDEY--------------TSSVGSKFPVRWSPPEVLMYSK--FSSKSDIWAFGVLMWEIYSLGK-MPYERF-TNSETAEHI----AQGLR---LY---RPHLASEKVYTIMYSCWHEKADERPTFKILLSN-I-
---LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL-RPDATKNARNDFLKEVKIMSRL-KDPNIIRLLGVCV-QDDPLCMITDYMENGDLNQFLSAHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNL-------YAGDYY--------------RVQGRAVLPIRWMAWECILMGK--FTTASDVWAFGVTLWEVLMLCRAQPFGQL-TDEQVIENAGEFFRDQGRQVYLS---RPPACPQGLYELMLRCWSRESEQRPPFSQLHRFL--
-LM--VDTVIGEGEFGEVYRGTLR-------------LPSQDCKTVAIKTL-KDTSPGGQWWNFLREATIMGQF-SHPHILHLEGVVT-KRKPIMIITEFMENGALDAFLRER--------------------------------------------------------------------------------------------------EDQLVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLL-------DDFDGT--------------YETQGGKIPIRWTAPEAIAHRI--FTTASDVWSFGIVMWEVLSFGD-KPYGEM-SNQEVMKSI----EDGYR---LP---PPVDCPAPLYELMKNCWAYDRARRPHFQKLQAHL--
--I-SIDKVVGAGEFGEVCSGRLK-------------LPSKKEISVAIKTL-KVGYTEKQRRDFLGEASIMGQF-DHPNIIRLEGVVT-KSKPVMIVTEYMENGSLDSFLRKH--------------------------------------------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVL-------EDDPEA-------------AYTTRGGKIPIRWTSPEAIAYRK--FTSASDVWSYGIVLWEVMSYGE-RPYWEM-SNQDVIKAV----DEGYR---LP---PPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSIL--
--L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVTKVAVKML-KSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKGNLREYLQARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI-------HHIDYY--------------KKTTNGRLPVKWMAPEALFDRI--YTHQSDVWSFGVLLWEIFTLGG-SPYPGV-PVEELFKLL----KEGHR---MD---KPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL--
---LKLGKSLGRGAFGKVVQASAFG-----------IKKSPTCRTVAVKML-KEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPR--------------------------------LDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDI-------YKNPDY--------------VRKGDTRLPLKWMAPESIFDKI--YSTKSDVWSYGVLLWEIFSLGG-SPYPGVQMDEDFCSRL----REGMR---MR---APEYSTPEIYQIMLDCWHRDPKERPRFAELVEKL--
---LHLGRVLGYGAFGKVVEASAFG-----------IHKGSSCDTVAVKML-KEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR-----------------------------------PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDI-------YKDPDY--------------VRKGSARLPLKWMAPESIFDKV--YTTQSDVWSFGVLLWEIFSLGA-SPYPGVQINEEFCQRL----RDGTR---MR---APELATPAIRRIMLNCWSGDPKARPAFSELVEIL--
---ITLLRELGQGSFGMVYEGNARD-----------IIKGEAETRVAVKTV-NESASLRERIEFLNEASVMKGF-TCHHVVRLLGVVS-KGQPTLVVMELMAHGDLKSYLRSLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDI-------YETDYY--------------RKGGKGLLPVRWMAPESLKDGV--FTTSSDMWSFGVVLWEITSLAE-QPYQGL-SNEQVLKFV----MDGGY---LD---QPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL--
---LTFVQEIGSGQFGLVHLGYWL-----------------NKDKVAIKTI-REGAMSE--EDFIEEAEVMMKL-SHPKLVQLYGVCL-EQAPICLVFEFMEHGCLSDYLRTQ--------------------------------------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFV--------LDDQY--------------TSSTGTKFPVKWASPEVFSFSR--YSSKSDVWSFGVLMWEVFSEGK-IPYENR-SNSEVVEDI----STGFR---LY---KPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQL--
---LSFGKTLGAGAFGKVVEATAYG-----------LIKSDAAMTVAVKML-KPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACT-IGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDI-------KNDSNY--------------VVKGNARLPVKWMAPESIFNCV--YTFESDVWSYGIFLWELFSLGS-SPYPGMPVDSKFYKMI----KEGFR---ML---SPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQL-I-
---LKLVERLGAGQFGEVWMGYYN-----------------GHTKVAVKSL-KQGSMSP--DAFLAEANLMKQL-QHQRLVRLYAVVT--QEPIYIITEYMENGSLVDFLKTP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--------EDNEY--------------TAREGAKFPIKWTAPEAINYGT--FTIKSDVWSFGILLTEIVTHGR-IPYPGM-TNPEVIQNL----ERGYR---MV---RPDNCPEELYQLMRLCWKERPEDRPTFDYLRSV-L-
---VHFNEVIGRGHFGCVYHGTLL-------------DNDGKKIHCAVKSL-NRITDIGEVSQFLTEGIIMKDF-SHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNE--------------------------------------------------------------------------------------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDM-------YDKEYYS------------VHNKTGAKLPVKWMALESLQTQK--FTTKSDVWSFGVLLWELMTRGA-PPYPDV-NTFDITVYL----LQGRR---LL---QPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSR-I-
--I-EYVRDIGEGAFGRVFQARAPG-----------LLPYEPFTMVAVKML-KEEASADMQADFQREAALMAEF-DNPNIVKLLGVCA-VGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHS---------------------------------------------------------------------------DLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNI-------YSADYY--------------KANENDAIPIRWMPPESIFYNR--YTTESDVWAYGVVLWEIFSYGL-QPYYGM-AHEEVIYYV----RDGNI---LS---CPENCPVELYNLMRLCWSKLPADRPSFTSIHRIL--
--I-VLKRELGEGAFGKVFLAECYN-----------LCPEQDKILVAVKTL-KDASDNA-RKDFHREAELLTNL-QHEHIVKFYGVCV-EGDPLIMVFEYMKHGDLNKFLRAHGPDAV--------------------------------------------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDV-------YSTDYY--------------RVGGHTMLPIRWMPPESIMYRK--FTTESDVWSLGVVLWEIFTYGK-QPWYQL-SNNEVIECI----TQGRV---LQ---RPRTCPQEVYELMLGCWQREPHMRKNIKGIHTL-L-
--I-VLKRELGEGAFGKVFLAECYN-----------LSPTKDKMLVAVKAL-KDPTLAA-RKDFQREAELLTNL-QHEHIVKFYGVCG-DGDPLIMVFEYMKHGDLNKFLRAHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDV-------YSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRK--FTTESDVWSFGVILWEIFTYGK-QPWFQL-SNTEVIECI----TQGRV---LE---RPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKIL--
--L-VLGRVLGSGAFGKVVEGTAYG-----------LSRSQPVMKVAVKML-KPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACT-KSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDI-------MHDSNY--------------VSKGSTFLPVKWMAPESIFDNL--YTTLSDVWSYGILLWEIFSLGG-TPYPGMMVDSTFYNKI----KSGYR---MA---KPDHATSEVYEIMVKCWNSEPEKRPSFYHLSE--IV
--L-VLGRTLGSGAFGQVVEATAHG-----------LSHSQATMKVAVKML-KSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACT-KGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDI-------MRDSNY--------------ISKGSTFLPLKWMAPESIFNSL--YTTLSDVWSFGILLWEIFTLGG-TPYPELPMNEQFYNAI----KRGYR---MA---QPAHASDEIYEIMQKCWEEKFEIRPPFSQLVL--LL
--V-VLNRILGEGFFGEVYEGVYT-------------NHKGEKINVAVKTC-KKDCTLDNKEKFMSEAVIMKNL-DHPHIVKLIGIIE--EEPTWIIMELYPYGELGHYLERN--------------------------------------------------------------------------------------------------KNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYI--------EDEDY--------------YKASVTRLPIKWMSPESINFRR--FTTASDVWMFAVCMWEILSFGK-QPFFWL-ENKDVIGVL----EKGDR---LP---KPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCS-L-
LES----AELDSGGFGKVSLCFHR-----------------TQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRL-RHSRVVKLLGVII-EEGKYSLVMEYMEKGNLMHVLKAE---------------------------------------------------------------------------------------------------MSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNE--EHNELR--------EVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFA-NK-EPYENAICEQQLIMCI----KSGNR---PDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEK-F-
---IKFQDVIGEGNFGQVLKARIK--------------KDGLRMDAAIKRM-KEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACE-HRGYLYLAIEYAPHGNLLDFLRKSRVLETDP-----------------------------------------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ----------EVY--------------VKKTMGRLPVRWMAIESLNYSV--YTTNSDVWSYGVLLWEIVSLGG-TPYCGM-TCAELYEKL----PQGYR---LE---KPLNCDDEVYDLMRQCWREKPYERPSFAQILV--SL
---ITFEDLIGEGNFGQVIRAMIK--------------KDGLKMNAAIKML-KEYASENDHRDFAGELEVLCKLGHHPNIINLLGACK-NRGYLYIAIEYAPYGNLLDFLRKSRVLETDP-----------------------------------------------------------------------------------AFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGE----------EVY--------------VKKTMGRLPVRWMAIESLNYSV--YTTKSDVWSFGVLLWEIVSLGG-TPYCGM-TCAELYEKL----PQGYR---ME---QPRNCDDEVYELMRQCWRDRPYERPPFAQIALQ-L-
--L-AFIKEIGSGQFGVVHLGEWR-----------------SHIQVAIKAI-NEGSMSE--EDFIEEAKVMMKL-SHSKLVQLYGVCI-QRKPLYIVTEFMENGCLLNYLREN--------------------------------------------------------------------------------------------------KGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYV--------LDDEY--------------VSSFGAKFPIKWSPPEVFLFNK--YSSKSDVWSFGVLMWEVFTEGK-MPFENK-SNLQVVEAI----SEGFR---LY---RPHLAPMSIYEVMYSCWHEKPEGRPTFAELLR--AV
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