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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK KDR 203
TK ALK 1116
TKL BRAF 456
TK EPHB4 615
TK IGF1R 999
TK INSR 1023
TK MET 1078
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
TK TEK 824
--LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKE-GATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSE---KNVVKICDFGLARDI---YKDPDY--------------VRKGDARLPLKWMAPETIFDRV---YTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTR----MRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL--
-I-TLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPE-VCSEQDELDFLMEALIISKF-NHQNIVRCIGVSL-QSLPRFILLELMAGGDLKSFLRETRP-----------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI---YRASYY--------------RKGGCAMLPVKWMPPEAFMEGI---FTSKTDTWSFGVLLWEIFSLGYMPYPSK-SNQEVLEFVTSGGR----MDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILER-I-
--ITVGQRIGSGSFGTVYKGKWH--------GDVAVKMLNVTAPTPQQLQAFKNEVGVLRKT-RHVNILLFMGYST--KPQLAIVTQWCEGSSLYHHLHII-----------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHE---DLTVKIGDFGLATVK---SRWSGS--------------HQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILA--SI
-V-KIEEVIGAGEFGEVCRGRLK--APGKKESCVAIKTLKG-GYTERQRREFLSEASIMGQF-EHPNIIRLEGVVT-NSMPVMILTEFMENGALDSFLRLN-----------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNS---NLVCKVSDFGLSRFLEENSSDPTY--------------TSSLGGKIPIRWTAPEAIAFRK---FTSASDAWSYGIVMWEVMSFGERPYWDM-SNQDVINAIEQDYR----LPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSAL--
--ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNE-AASMRERIEFLNEASVMKEF-NCHHVVRLLGVVS-QGQPTLVIMELMTRGDLKSYLRSLRPEM--------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE---DFTVKIGDFGMTRDI---YETDYY--------------RKGGKGLLPVRWMSPESLKDGV---FTTYSDVWSFGVVLWEIATLAEQPYQGL-SNEQVLRFVMEGGL----LDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISS-I-
--ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNE-SASLRERIEFLNEASVMKGF-TCHHVVRLLGVVS-KGQPTLVVMELMAHGDLKSYLRSLRPEA--------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH---DFTVKIGDFGMTRDI---YETDYY--------------RKGGKGLLPVRWMAPESLKDGV---FTTSSDMWSFGVVLWEITSLAEQPYQGL-SNEQVLKFVMDGGY----LDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL--
--VHFNEVIGRGHFGCVYHGTLL--DNDGKKIHCAVKSLNR-ITDIGEVSQFLTEGIIMKDF-SHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNE-----------------------------------------------------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDE---KFTVKVADFGLARDM---YDKEYYS------------VHNKTGAKLPVKWMALESLQTQK---FTTKSDVWSFGVLLWELMTRGAPPYPDV-NTFDITVYLLQGRR----LLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSR-I-
IV--LKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKE-ASESA-RQDFQREAELLTML-QHQHIVRFFGVCT-EGRPLLMVFEYMRHGDLNRFLRSHGPDAKL---------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ---GLVVKIGDFGMSRDI---YSTDYY--------------RVGGRTMLPIRWMPPESILYRK---FTTESDVWSFGVVLWEIFTYGKQPWYQL-SNTEAIDCITQGRE----LERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL--
-I-VLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKD-ASDNA-RKDFHREAELLTNL-QHEHIVKFYGVCV-EGDPLIMVFEYMKHGDLNKFLRAHGPDAV-----------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGE---NLLVKIGDFGMSRDV---YSTDYY--------------RVGGHTMLPIRWMPPESIMYRK---FTTESDVWSLGVVLWEIFTYGKQPWYQL-SNNEVIECITQGRV----LQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTL-L-
-I-VLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKD-PTLAA-RKDFQREAELLTNL-QHEHIVKFYGVCG-DGDPLIMVFEYMKHGDLNKFLRAHGPDAMIL--------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGA---NLLVKIGDFGMSRDV---YSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRK---FTTESDVWSFGVILWEIFTYGKQPWFQL-SNTEVIECITQGRV----LERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKIL--
--IKFQDVIGEGNFGQVLKARIK---KDGLRMDAAIKRMKE-YASKDDHRDFAGELEVLCKLGHHPNIINLLGACE-HRGYLYLAIEYAPHGNLLDFLRKSRVLETDP--------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGE---NYVAKIADFGLSRGQ------EVY--------------VKKTMGRLPVRWMAIESLNYSV---YTTNSDVWSYGVLLWEIVSLGGTPYCGM-TCAELYEKLPQGYR----LEKPLNCDDEVYDLMRQCWREKPYERPSFAQILV--SL
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