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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK LCK 203
TK ABL1 261
TK ALK 1116
Other AURKA 133
CMGC CDK2 4
CAMK DAPK1 13
TK EGFR 712
Other EIF2AK2 267
TK EPHA2 613
TK EPHA3 621
TK ERBB3 709
TK FGFR1 478
TK FGFR2 481
TK HCK 241
TK IGF1R 999
TK INSR 1023
TKL IRAK4 186
TK KIT 589
Other NEK2 8
STE OXSR1 17
TK PTK2B 425
TK RET 724
TK SRC 270
STE STK24 24
TK TNK2 150
TK ZAP70 338
----LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-Q--G-SM-SP--D-AFL-A----EANLMKQL-QHQRLVRLYAVVT------------------------------QEPIYIITEYMENGSLVDFLK---------TP--------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEER-----NYIHRDLRAANILVSD---TLSC----KIADFGLARLI-------E--DNEY-TAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGR-IPYPGM-TNPEVIQNL-ERGYRMVRPDNCP----------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L---
----ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-E--D-TM-EV--E-EFL-K----EAAVMKEI-KHPNLVQLLGVCTR-----------------------------EPPFYIITEFMTYGNLLDYLR---------EC--------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKK-----NFIHRDLAARNCLVGE---NHLV----KVADFGLSRLM-------T--GDTY-TAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGM-SPYPGI-DLSQVYELL-EKDYRMERPEGCP----------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F---
---I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLP-E--V-CS-EQDEL-DFL-M----EALIISKF-NHQNIVRCIGVSLQ-----------------------------SLPRFILLELMAGGDLKSFLR---------ETRP---------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEEN-----HFIHRDIAARNCLLTCPGPGRVA----KIGDFGMARDI---Y---R--ASYY-RKGGCAMLPVKWMPPEAFM-EGIFTSKTDTWSFGVLLWEIFSLGY-MPYPSK-SNQEVLEFV-TSGGRMDPPKNCP----------------------------GPVYRIMTQCWQHQPEDRPNFAIILER--I---
----FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKA--QLEKAGV--E-HQLRR----EVEIQSHL-RHPNILRLYGYFHD-----------------------------ATRVYLILEYAPLGTVYRELQ--------KLS-----------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSK-----RVIHRDIKPENLLLGS---AGEL----KIADFGWSV---------HAPSSRR-TT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GK-PPFEAN----TYQETY-KRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI---
----FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLD--T-ETEGV--P-STAIR----EISLLKEL-NHPNIVKLLDVIHT-----------------------------ENKLYLVFEFLHQ-DLKKFMDA------SALT-----------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSH-----RVLHRDLKPQNLLINT---EGAI----KLADFGLARAF-------GVPVRTY-TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RR-ALFPGD-SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF---
----YDTGEELGSGQFAVVKKCREK-------STGLQYAAKFIKKR--R-TKSSR--R-GVSREDIEREVSILKEI-QHPNVITLHEVYEN-----------------------------KTDVILILELVAGGELFDFLA--------EKE-----------------------------------------------------------------------------SLTEEEATEFLKQILNGVYYLHSL-----QIAHFDLKPENIMLLD---RNVPKPRIKIIDFGLAHK--------IDFGNEF-KN---IFGTPEFVAPEIVN-YEPLGLEADMWSIGVITYILLS-GA-SPFLGD----TKQETL-ANVSAVNYEFEDEYFSNTS----------------------ALAKDFIRRLLVKDPKKRMTIQDSLQHPWI---
---F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-E--A-TS-PKANK-EIL-D----EAYVMASV-DNPHVCRLLGICL------------------------------TSTVQLITQLMPFGCLLDYVR---------EH---------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDR-----RLVHRDLAARNVLVKT---PQHV----KITDFGLAKLL---G---A--EEKE-YHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGS-KPYDGI-PASEISSIL-EKGERLPQPPICT----------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF-
---F-KEIELIGSGGFGQVFKAKHR-------IDGKTYVIKRVKYN--N-EKAER-------------EVKALAKL-DHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEK------RRGE-----------------------------------------------------------------------------KLDKVLALELFEQITKGVDYIHSK-----KLIHRDLKPSNIFLVD---TKQV----KIGDFGLVTS--------LKNDGKR-TR---SKGTLRYMSPEQIS-SQDYGKEVDLYALGLILAELLH-VCDTAFET--------SKF-FTDLRDGIISDIFDK---------------------------KEKTLLQKLLSKKPEDRPNTSEILR----TLT
---V-TRQKVIGAGEFGEVYKGMLKT---SSGKKEVPVAIKTLK-A--G-YT-EKQRV-DFL-G----EAGIMGQF-SHHNIIRLEGVISK-----------------------------YKPMMIITEYMENGALDKFLR---------EK---------------------------------------------------------------------------DGEFSVLQLVGMLRGIAAGMKYLANM-----NYVHRDLAARNILVNS---NLVC----KVSDFGLSRVL---E---D--DPEATYTTSGGKIPIRWTAPEAIS-YRKFTSASDVWSFGIVMWEVMTYGE-RPYWEL-SNHEVMKAI-NDGFRLPTPMDCP----------------------------SAIYQLMMQCWQQERARRPKFADIVSIL-----
---I-SIDKVVGAGEFGEVCSGRLK----LPSKKEISVAIKTLK-V--G-YT-EKQRR-DFL-G----EASIMGQF-DHPNIIRLEGVVTK-----------------------------SKPVMIVTEYMENGSLDSFLR---------KH---------------------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDM-----GYVHRDLAARNILINS---NLVC----KVSDFGLSRVL---E---D--DPEAAYTTRGGKIPIRWTSPEAIA-YRKFTSASDVWSYGIVLWEVMSYGE-RPYWEM-SNQDVIKAV-DEGYRLPPPMDCP----------------------------AALYQLMLDCWQKDRNNRPKFEQIVSIL-----
---L-RKLKVLGSGVFGTVHKGVWIP---EGESIKIPVCIKVIE-D--K-SG-RQSFQ-AVT-D----HMLAIGSL-DHAHIVRLLGLCP------------------------------GSSLQLVTQYLPLGSLLDHVR---------QH---------------------------------------------------------------------------RGALGPQLLLNWGVQIAKGMYYLEEH-----GMVHRNLAARNVLLKS---PSQV----QVADFGVADLL---P---P--DDKQ-LLYSEAKTPIKWMALESIH-FGKYTHQSDVWSYGVTVWELMTFGA-EPYAGL-RLAEVPDLL-EKGERLAQPQICT----------------------------IDVYMVMVKCWMIDENIRPTFKELANE--F---
---L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-S--D-AT-EKDLS-DLI-S----EMEMMKMIGKHKNIINLLGACTQ-----------------------------DGPLYVIVEYASKGNLREYLQ---------ARRPPGLEY------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK-----KCIHRDLAARNVLVTE---DNVM----KIADFGLARDI---H---H--IDYY-KKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGG-SPYPGV-PVEELFKLL-KEGHRMDKPSNCT----------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL-----
----LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-D--D-AT-EKDLS-DLV-S----EMEMMKMIGKHKNIINLLGACTQ-----------------------------DGPLYVIVEYASKGNLREYLR---------ARRPPGMEY------------------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQ-----KCIHRDLAARNVLVTE---NNVM----KIADFGLARDI---N---N--IDYY-KKTTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLMWEIFTLGG-SPYPGI-PVEELFKLL-KEGHRMDKPANCT----------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL-----
----LKLEKKLGAGQFGEVWMATYN--------KHTKVAVKTMK-P--G-SM-SV--E-AFL-A----EANVMKTL-QHDKLVKLHAVVT------------------------------KEPIYIITEFMAKGSLLDFLK---------SD--------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQR-----NYIHRDLRAANILVSA---SLVC----KIADFGLARVI-------E--DNEY-TAREGAKFPIKWTAPEAIN-FGSFTIKSDVWSFGILLMEIVTYGR-IPYPGM-SNPEVIRAL-ERGYRMPRPENCP----------------------------EELYNIMMRCWKNRPEERPTFEYIQSV--L---
----ITMSRELGQGSFGMVYEGVAKG--VVKDEPETRVAIKTVN-E--A-AS-MRERI-EFL-N----EASVMKEF-NCHHVVRLLGVVSQ-----------------------------GQPTLVIMELMTRGDLKSYLR---------SLRPEM------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNAN-----KFVHRDLAARNCMVAE---DFTV----KIGDFGMTRDI---Y---E--TDYY-RKGGKGLLPVRWMSPESLK-DGVFTTYSDVWSFGVVLWEIATLAE-QPYQGL-SNEQVLRFV-MEGGLLDKPDNCP----------------------------DMLFELMRMCWQYNPKMRPSFLEIISS--I---
----ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVN-E--S-AS-LRERI-EFL-N----EASVMKGF-TCHHVVRLLGVVSK-----------------------------GQPTLVVMELMAHGDLKSYLR---------SLRPEA------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAK-----KFVHRDLAARNCMVAH---DFTV----KIGDFGMTRDI---Y---E--TDYY-RKGGKGLLPVRWMAPESLK-DGVFTTSSDMWSFGVVLWEITSLAE-QPYQGL-SNEQVLKFV-MDGGYLDQPDNCP----------------------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL-----
-VGG----NKMGEGGFGVVYKGYVN-------NTT--VAVKKLAAM--V-DITTE--ELKQQFD---QEIKVMAKC-QHENLVELLGFSSD-----------------------------GDDLCLVYVYMPNGSLLDRLSC-----LDGTP-----------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHEN-----HHIHRDIKSANILLDE---AFTA----KISDFGLARASE-----KFAQTVMT-SR---IVGTTAYMAPEALR--GEITPKSDIYSFGVVLLEIIT-GL-PAVDEH-REPQLLLDI-KEEIEDEEKTIEDYIDKKMNDAD--------------STSVEAMYSVASQCLHEKKNKRPDIKKVQQ----LLQ
----LSFGKTLGAGAFGKVVEATAYG--LIKSDAAMTVAVKMLK-P--S-AH-LTERE-ALM-S----ELKVLSYLGNHMNIVNLLGACTI-----------------------------GGPTLVITEYCCYGDLLNFLR---------RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASK-----NCIHRDLAARNILLTH---GRIT----KICDFGLARDI---K---N--DSNY-VVKGNARLPVKWMAPESIF-NCVYTFESDVWSYGIFLWELFSLGS-SPYPGMPVDSKFYKMI-KEGFRMLSPEHAP----------------------------AEMYDIMKTCWDADPLKRPTFKQIVQL--I---
----YEVLYTIGTGSYGRCQKIRRK-------SDGKILVWKELDYG--S-MTEAE--K-QMLVS----EVNLLREL-KHPNIVRYYDRIIDR---------------------------TNTTLYIVMEYCEGGDLASVITKG----TKERQ-----------------------------------------------------------------------------YLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDG---KQNV----KLGDFGLARIL-------NHDTSFA-KT---FVGTPYYMSPEQMN-RMSYNEKSDIWSLGCLLYELCA-LM-PPFTAF----SQKELA-GKIREGKFRRIPYRY---S----------------------DELNEIITRMLNLKDYHRPSVEEILENPL-I--
----YELQEVIGSGATAVVQAAYCA-------PKKEKVAIKRINLE--K-CQTSM--D-E-LLK----EIQAMSQC-HHPNIVSYYTSFVV-----------------------------KDELWLVMKLLSGGSVLDIIKHIVAKGEHKSG-----------------------------------------------------------------------------VLDESTIATILREVLEGLEYLHKN-----GQIHRDVKAGNILLGE---DGSV----QIADFGVSAFLAT--GGDITRNKVR-KT---FVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELAT-GA-APYHKY-PPMKVLMLT-LQNDPPSLETGVQDKE--MLK-----------------KYGKSFRKMISLCLQKDPEKRPTAAELLRHKFF---
---V-VLNRILGEGFFGEVYEGVYT----NHKGEKINVAVKTCK-K--D-CT-LDNKE-KFM-S----EAVIMKNL-DHPHIVKLIGIIE------------------------------EEPTWIIMELYPYGELGHYLE---------RN---------------------------------------------------------------------------KNSLKVLTLVLYSLQICKAMAYLESI-----NCVHRDIAVRNILVAS---PECV----KLGDFGLSRYI-------E--DEDY-YKASVTRLPIKWMSPESIN-FRRFTTASDVWMFAVCMWEILSFGK-QPFFWL-ENKDVIGVL-EKGDRLPKPDLCP----------------------------PVLYTLMTRCWDYDPSDRPRFTELVCS--L---
---L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-E--N-AS-PSELR-DLL-S----EFNVLKQV-NHPHVIKLYGACSQ-----------------------------DGPLLLIVEYAKYGSLRGFLR---------ESRKVGPGYLGSG----------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM-----KLVHRDLAARNILVAE---GRKM----KISDFGLSRDV---Y---E--EDSY-VKRSQGRIPVKWMAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGG-NPYPGI-PPERLFNLL-KTGHRMERPDNCS----------------------------EEMYRLMLQCWKQEPDKRPVFADISKDL-----
---L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-P--G-TM-SP--E-AFL-Q----EAQVMKKL-RHEKLVQLYAVVS------------------------------EEPIYIVTEYMSKGSLLDFLK---------GE--------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERM-----NYVHRDLRAANILVGE---NLVC----KVADFGLARLI-------E--DNEY-TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGR-VPYPGM-VNREVLDQV-ERGYRMPCPPECP----------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L---
----FTKLEKIGKGSFGEVFKGIDN-------RTQKVVAIKIIDLE--E-AEDEI--E-DIQ-Q----EITVLSQC-DSPYVTKYYGSYLK-----------------------------DTKLWIIMEYLGGGSALDLLE---------PG-----------------------------------------------------------------------------PLDETQIATILREILKGLDYLHSE-----KKIHRDIKAANVLLSE---HGEV----KLADFGVAGQL-------TDTQIKR-NT---FVGTPFWMAPEVIK-QSAYDSKADIWSLGITAIELAR-GE-PPHSEL-HPMKVLFLI-PKNNPPTLEGNYS----------------------------KPLKEFVEACLNKEPSFRPTAKELLKHKFI---
---L-RLLEKLGDGSFGVVRRGEWD----APSGKTVSVAVKCLK-PDVL-SQ-PEAMD-DFI-R----EVNAMHSL-DHRNLIRLYGVVL------------------------------TPPMKMVTELAPLGSLLDRLR---------KH---------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESK-----RFIHRDLAARNLLLAT---RDLV----KIGDFGLMRAL--PQ---N--DDHY-VMQEHRKVPFAWCAPESLK-TRTFSHASDTWMFGVTLWEMFTYGQ-EPWIGL-NGSQILHKIDKEGERLPRPEDCP----------------------------QDIYNVMVQCWAHKPEDRPTFVALRDF--L---
LIAD----IELGCGNFGSVRQGVYR-----MRKKQIDVAIKVLK-Q--G-TE-KADTE-EMM-R----EAQIMHQL-DNPYIVRLIGVCQ------------------------------AEALMLVMEMAGGGPLHKFLV---------GK---------------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEEK-----NFVHRDLAARNVLLVN---RHYA----KISDFGLSKAL--GA---D--DSYY-TARSAGKWPLKWYAPECIN-FRKFSSRSDVWSYGVTMWEALSYGQ-KPYKKM-KGPEVMAFI-EQGKRMECPPECP----------------------------PELYALMSDCWIYKWEDRPDFLTVEQR--M---
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