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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK LCK 203
TK ABL1 261
Other AURKA 133
Other AURKC 43
TK BMX 422
TKL BRAF 456
TK CSF1R 582
TK DDR1 572
TK EPHA3 621
TK EPHA7 633
TK FGFR1 478
TK FLT1 827
TK FLT4 845
TK INSR 1023
TK KDR 834
TK KIT 589
TKL LIMK2 331
CMGC MAPK14 24
TK MET 1078
TK MUSK 575
TK NTRK2 538
TK NTRK3 538
TK PDGFRA 593
TK PDGFRB 600
TKL RIPK1 17
TK SRC 270
TK TEK 824
TK TIE1 839
---LKLVERLGAGQFGEVWMGYYN-----------------GHTKVAV-KSL-K-Q-G-SM-SP--DAFL-A-EANLMKQL-QHQRLVRLYAVVT--------QEPIYIITEYMENGSLVDFLK-TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--------------E--DNEY--------------TAREGAKFPIKWTAPEAIN-YGT---FTIKSDVWSFGILLTEIVTHGR-IPYPGM-TNPEVIQNL----ERGYR----MV---RPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L-
---ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAV-KTL-K-E-D-TM-EV--EEFL-K-EAAVMKEI-KHPNLVQLLGVCT-R------EPPFYIITEFMTYGNLLDYLR-EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM--------------T--GDTY--------------TAHAGAKFPIKWTAPESLA-YNK---FSIKSDVWAFGVLLWEIATYGM-SPYPGI-DLSQVYELL----EKDYR----ME---RPEGCP------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F-
---FEIGRPLGKGKFGNVYLAREK----------------QSKFILAL-KVL-FKA-QLEKAGV--EHQLRR-EVEIQSHL-RHPNILRLYGYFH-D------ATRVYLILEYAPLGTVYRELQKLS----------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV----------------HAPSSRR--------------TT---LCGTLDYLPPEMIE-GRM---HDEKVDLWSLGVLCYEFLV-GK-PPFEAN----TYQETY----KRISR----VE---FTFPDFVT----------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI-
---FEIGRPLGKGKFGNVYLARLK----------------ESHFIVAL-KVL-FKS-Q-IEKEG--LEHQLRREIEIQAHL-QHPNILRLYNYFH-D------ARRVYLILEYAPRGELYKELQKSE----------------------------------------------------------------------------------------------------KLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSV----------------HTPSLRR--------------KT---MCGTLDYLPPEMIE-GRT---YDEKVDLWCIGVLCYELLV-GY-PPFESA----SHSETY----RRILK----VD---VRFPLSMP----------------------------LGARDLISRLLRYQPLERLPLAQILKHPWV-
---ITLLKELGSGQFGVVQLGKWK-----------------GQYDVAV-KMI-K-E-G-SM-SE--DEFF-Q-EAQTMMKL-SHPKLVKFYGVCS-K------EYPIYIVTEYISNGCLLNYLR-SH--------------------------------------------------------------------------------------------------GKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYV--------------L--DDQY--------------VSSVGTKFPVKWSAPEVFH-YFK---YSSKSDVWAFGILMWEVFSLGK-QPYDLY-DNSQVVLKV----SQGHR----LY---RPHLAS------------------------------DTIYQIMYSCWHELPEKRPTFQQLLSS--I-
---ITVGQRIGSGSFGTVYKGKWH-------------------GDVAV-KML-N-VTA-PT-PQQLQAFK-N-EVGVLRKT-RHVNILLFMGYST--------KPQLAIVTQWCEGSSLYHHLH-II--------------------------------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVK-------------SR--WSGS--------------HQFEQLSGSILWMAPEVIR-MQDKNPYSFQSDVYAFGIVLYELMT-GQ-LPYSNINNRDQIIFMV----GRGYLSPDLSK---VRSNCP------------------------------KAMKRLMAECLKKKRDERPLFPQILA---SI
---LQFGKTLGAGAFGKVVEATAFG-----------LGKEDAVLKVAV-KML-K-S-T-AH-ADEKEALM-S-ELKIMSHLGQHENIVNLLGACT-H------GGPVLVITEYCCYGDLLNFLR-RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDI-------------MN--DSNY--------------IVKGNARLPVKWMAPESIF-DCV---YTVQSDVWSYGILLWEIFSLGL-NPYPGILVNSKFYKLV----KDGYQ----MA---QPAFAP------------------------------KNIYSIMQACWALEPTHRPTFQQICSFL---
---LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAV-KIL-R-P-D-AT-KNARNDFL-K-EVKIMSRL-KDPNIIRLLGVCV-Q------DDPLCMITDYMENGDLNQFLS-AHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNL-------------YA--GDYY--------------RVQGRAVLPIRWMAWECIL-MGK---FTTASDVWAFGVTLWEVLMLCRAQPFGQL-TDEQVIENAGEFFRDQGRQ-VYLS---RPPACP------------------------------QGLYELMLRCWSRESEQRPPFSQLHRFL---
--I-SIDKVVGAGEFGEVCSGRLK-------------LPSKKEISVAI-KTL-K-V-G-YT-EKQRRDFL-G-EASIMGQF-DHPNIIRLEGVVT-K------SKPVMIVTEYMENGSLDSFLR-KH--------------------------------------------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVL-------------ED--DPEA-------------AYTTRGGKIPIRWTSPEAIA-YRK---FTSASDVWSYGIVLWEVMSYGE-RPYWEM-SNQDVIKAV----DEGYR----LP---PPMDCP------------------------------AALYQLMLDCWQKDRNNRPKFEQIVSIL---
---IKIERVIGAGEFGEVCSGRLK-------------LPGKRDVAVAI-KTL-K-V-G-YT-EKQRRDFL-C-EASIMGQF-DHPNVVHLEGVVT-R------GKPVMIVIEFMENGALDAFLR-KH--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVI-------------ED--DPEA-------------VYTTTGGKIPVRWTAPEAIQ-YRK---FTSASDVWSYGIVMWEVMSYGE-RPYWDM-SNQDVIKAI----EEGYR----LP---APMDCP------------------------------AGLHQLMLDCWQKERAERPKFEQIVGI--L-
--L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVTKVAV-KML-K-S-D-AT-EKDLSDLI-S-EMEMMKMIGKHKNIINLLGACT-Q------DGPLYVIVEYASKGNLREYLQ-ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI-------------HH--IDYY--------------KKTTNGRLPVKWMAPEALF-DRI---YTHQSDVWSFGVLLWEIFTLGG-SPYPGV-PVEELFKLL----KEGHR----MD---KPSNCT------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL---
---LKLGKSLGRGAFGKVVQASAFG-----------IKKSPTCRTVAV-KML-K-E-G-AT-ASEYKALM-T-ELKILTHIGHHLNVVNLLGACTKQ------GGPLMVIVEYCKYGNLSNYLK-SKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPR--------------------------------LDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDI-------------YK--NPDY--------------VRKGDTRLPLKWMAPESIF-DKI---YSTKSDVWSYGVLLWEIFSLGG-SPYPGVQMDEDFCSRL----REGMR----MR---APEYST------------------------------PEIYQIMLDCWHRDPKERPRFAELVEKL---
---LHLGRVLGYGAFGKVVEASAFG-----------IHKGSSCDTVAV-KML-K-E-G-AT-ASEHRALM-S-ELKILIHIGNHLNVVNLLGACTKP------QGPLMVIVEFCKYGNLSNFLR-AKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR-----------------------------------PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDI-------------YK--DPDY--------------VRKGSARLPLKWMAPESIF-DKV---YTTQSDVWSFGVLLWEIFSLGA-SPYPGVQINEEFCQRL----RDGTR----MR---APELAT------------------------------PAIRRIMLNCWSGDPKARPAFSELVEIL---
---ITLLRELGQGSFGMVYEGNARD-----------IIKGEAETRVAV-KTV-N-E-S-AS-LRERIEFL-N-EASVMKGF-TCHHVVRLLGVVS-K------GQPTLVVMELMAHGDLKSYLR-SLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDI-------------YE--TDYY--------------RKGGKGLLPVRWMAPESLK-DGV---FTTSSDMWSFGVVLWEITSLAE-QPYQGL-SNEQVLKFV----MDGGY----LD---QPDNCP------------------------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL---
---LKLGKPLGRGAFGQVIEADAFG-----------IDKTATCRTVAV-KML-K-E-G-AT-HSEHRALM-S-ELKILIHIGHHLNVVNLLGACTKP------GGPLMVIVEFCKFGNLSTYLR-SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDI-------------YK--DPDY--------------VRKGDARLPLKWMAPETIF-DRV---YTIQSDVWSFGVLLWEIFSLGA-SPYPGVKIDEEFCRRL----KEGTR----MR---APDYTT------------------------------PEMYQTMLDCWHGEPSQRPTFSELVEHL---
---LSFGKTLGAGAFGKVVEATAYG-----------LIKSDAAMTVAV-KML-K-P-S-AH-LTEREALM-S-ELKVLSYLGNHMNIVNLLGACT-I------GGPTLVITEYCCYGDLLNFLR-RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDI-------------KN--DSNY--------------VVKGNARLPVKWMAPESIF-NCV---YTFESDVWSYGIFLWELFSLGS-SPYPGMPVDSKFYKMI----KEGFR----ML---SPEHAP------------------------------AEMYDIMKTCWDADPLKRPTFKQIVQL--I-
-LI--HGEVLGKGFFGQAIKVTHK-----------------ATGKVMVMKEL---I-R-CD-EETQKTFL-T-EVKVMRSL-DHPNVLKFIGVLY-K------DKKLNLLTEYIEGGTLKDFLR-SM---------------------------------------------------------------------------------------------------DPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATT------KKRTL-----RKNDRKKRYTVVGNPYWMAPEMLN-GKS---YDETVDIFSFGIVLCEIIGQVY-ADPDCLPRTLDFGLNV----KLFWE----KF---VPTDCP------------------------------PAFFPLAAICCRLEPESRPAFSKLED---SF
---YQNLSPVGSGAYGSVCAAFDT----------------KTGLRVAV-KKL-SRP-F-QSIIH--AKRTYR-ELRLLKHM-KHENVIGLLDVFT-PARSLEEFNDVYLVTHLMGA-DLNNIVK-CQ----------------------------------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-----------------HTDDEM--------------TG---YVATRWYRAPEIMLNWMH---YNQTVDIWSVGCIMAELLT-GR-TLFPGT-DHIDQLKLI----LRLVG----TP---GAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF-
---VHFNEVIGRGHFGCVYHGTLL-------------DNDGKKIHCAV-KSL-N-R-I-TD-IGEVSQFL-T-EGIIMKDF-SHPNVLSLLGICLRS------EGSPLVVLPYMKHGDLRNFIR-NE--------------------------------------------------------------------------------------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDM-------------YD--KEYYS------------VHNKTGAKLPVKWMALESLQ-TQK---FTTKSDVWSFGVLLWELMTRGA-PPYPDV-NTFDITVYL----LQGRR----LL---QPEYCP------------------------------DPLYEVMLKCWHPKAEMRPSFSELVSR--I-
--I-EYVRDIGEGAFGRVFQARAPG-----------LLPYEPFTMVAV-KML-K-E-E-AS-ADMQADFQ-R-EAALMAEF-DNPNIVKLLGVCA-V------GKPMCLLFEYMAYGDLNEFLR-SMSPHTVCSLSHS---------------------------------------------------------------------------DLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNI-------------YS--ADYY--------------KANENDAIPIRWMPPESIF-YNR---YTTESDVWAYGVVLWEIFSYGL-QPYYGM-AHEEVIYYV----RDGNI----LS---CPENCP------------------------------VELYNLMRLCWSKLPADRPSFTSIHRIL---
--I-VLKRELGEGAFGKVFLAECYN-----------LCPEQDKILVAV-KTL-K-D-A-SD-NA-RKDFH-R-EAELLTNL-QHEHIVKFYGVCV-E------GDPLIMVFEYMKHGDLNKFLR-AHGPDAV--------------------------------------------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDV-------------YS--TDYY--------------RVGGHTMLPIRWMPPESIM-YRK---FTTESDVWSLGVVLWEIFTYGK-QPWYQL-SNNEVIECI----TQGRV----LQ---RPRTCP------------------------------QEVYELMLGCWQREPHMRKNIKGIHTL--L-
--I-VLKRELGEGAFGKVFLAECYN-----------LSPTKDKMLVAV-KAL-K-D-P-TL-AA-RKDFQ-R-EAELLTNL-QHEHIVKFYGVCG-D------GDPLIMVFEYMKHGDLNKFLR-AHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDV-------------YS--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-YRK---FTTESDVWSFGVILWEIFTYGK-QPWFQL-SNTEVIECI----TQGRV----LE---RPRVCP------------------------------KEVYDVMLGCWQREPQQRLNIKEIYKIL---
--L-VLGRVLGSGAFGKVVEGTAYG-----------LSRSQPVMKVAV-KML-K-P-T-AR-SSEKQALM-S-ELKIMTHLGPHLNIVNLLGACT-K------SGPIYIITEYCFYGDLVNYLH-KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDI-------------MH--DSNY--------------VSKGSTFLPVKWMAPESIF-DNL---YTTLSDVWSYGILLWEIFSLGG-TPYPGMMVDSTFYNKI----KSGYR----MA---KPDHAT------------------------------SEVYEIMVKCWNSEPEKRPSFYHLSE---IV
--L-VLGRTLGSGAFGQVVEATAHG-----------LSHSQATMKVAV-KML-K-S-T-AR-SSEKQALM-S-ELKIMSHLGPHLNVVNLLGACT-K------GGPIYIITEYCRYGDLVDYLH-RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDI-------------MR--DSNY--------------ISKGSTFLPLKWMAPESIF-NSL---YTTLSDVWSFGILLWEIFTLGG-TPYPELPMNEQFYNAI----KRGYR----MA---QPAHAS------------------------------DEIYEIMQKCWEEKFEIRPPFSQLVL---LL
LES----AELDSGGFGKVSLCFHR-----------------TQGLMIM-KTVYK-G-P-NC-IEHNEALL-E-EAKMMNRL-RHSRVVKLLGVII-E------EGKYSLVMEYMEKGNLMHVLK-AE---------------------------------------------------------------------------------------------------MSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWS------KLNNE----EHNELR--------EVDGTAKKNGGTLYYMAPEHLN-DVNA-KPTEKSDVYSFAVVLWAIFA-NK-EPYENAICEQQLIMCI----KSGNR----PDVDDITEYCP------------------------------REIISLMKLCWEANPEARPTFPGIEEK--F-
--L-RLEVKLGQGCFGEVWMGTWN-----------------GTTRVAI-KTL-K-P-G-TM-SP--EAFL-Q-EAQVMKKL-RHEKLVQLYAVVS--------EEPIYIVTEYMSKGSLLDFLK-GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--------------E--DNEY--------------TARQGAKFPIKWTAPEAAL-YGR---FTIKSDVWSFGILLTELTTKGR-VPYPGM-VNREVLDQV----ERGYR----MP---CPPECP------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L-
---IKFQDVIGEGNFGQVLKARIK--------------KDGLRMDAAI-KRM-K-E-Y-AS-KDDHRDFA-G-ELEVLCKLGHHPNIINLLGACE-H------RGYLYLAIEYAPHGNLLDFLR-KSRVLETDP-----------------------------------------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ------------------EVY--------------VKKTMGRLPVRWMAIESLN-YSV---YTTNSDVWSYGVLLWEIVSLGG-TPYCGM-TCAELYEKL----PQGYR----LE---KPLNCD------------------------------DEVYDLMRQCWREKPYERPSFAQILV---SL
---ITFEDLIGEGNFGQVIRAMIK--------------KDGLKMNAAI-KML-K-E-Y-AS-ENDHRDFA-G-ELEVLCKLGHHPNIINLLGACK-N------RGYLYIAIEYAPYGNLLDFLR-KSRVLETDP-----------------------------------------------------------------------------------AFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGE------------------EVY--------------VKKTMGRLPVRWMAIESLN-YSV---YTTKSDVWSFGVLLWEIVSLGG-TPYCGM-TCAELYEKL----PQGYR----ME---QPRNCD------------------------------DEVYELMRQCWRDRPYERPPFAQIALQ--L-
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