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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK LCK 203
Other AURKA 133
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK5 4
TK CSF1R 582
TK FGFR1 478
CMGC MAPK14 24
TK NTRK1 510
AGC PRKCB 342
TK SRC 270
TK SYK 371
TK ZAP70 338
----LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-QG-SM-SP---DAFL-A-EANLMKQL--QHQRLVRLYAVVT-------QEPIYIITEYMENGSLVDFLK----TP-------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--E--DNEY-TAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNLERGYRMVRPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L--------------
----FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKAQLEKAGV---EHQLRR-EVEIQSHL--RHPNILRLYGYFHD------ATRVYLILEYAPLGTVYRELQ---KLS----------------------------------------------------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV----HAPSSRR-TT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN----TYQETYKRISRVEFTFPDFVT----------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI--------------
----YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKIRLES-EEEGV---PSTAIR-EISLLKEL--RHPNIVSLQDVLMQ------DSRLYLIFEFLSM-DLKKYLDSIPPGQ----------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF--GIPIRVY-TH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP--GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--------------
----FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLDT-ETEGV---PSTAIR-EISLLKEL--NHPNIVKLLDVIHT------ENKLYLVFEFLHQ-DLKKFMDA-SALT----------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTY-TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--------------
----YEKLEKIGEGTYGTVFKAKNR-------ETHEIVALKRVRLDD-DDEGV---PSSALR-EICLLKEL--KHKNIVRLHDVLHS------DKKLTLVFEFCDQ-DLKKYFD--SCNG----------------------------------------------------------------------DLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF--GIPVRCY-SA---EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGN-DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT--TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF--------------
----LQFGKTLGAGAFGKVVEATAFG--LGKEDAVLKVAVKMLK-ST-AH-ADE-KEALM-S-ELKIMSHLG-QHENIVNLLGACTH------GGPVLVITEYCCYGDLLNFLR----RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDI-MN--DSNY-IVKGNARLPVKWMAPESIF-DCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAP------------------------------KNIYSIMQACWALEPTHRPTFQQICSFL----------------
---L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SD-AT-EKD-LSDLI-S-EMEMMKMIG-KHKNIINLLGACTQ------DGPLYVIVEYASKGNLREYLQ----ARRPPGLEY-----------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI-HH--IDYY-KKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELFKLLKEGHRMDKPSNCT------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL----------------
----YQNLSPVGSGAYGSVCAAFDT-------KTGLRVAVKKLSRPF-QSIIH---AKRTYR-ELRLLKHM--KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVK----CQ----------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-----HTDDEM-TG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGT-DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF--------------
--IV--LKWELGEGAFGKVFLAECHN--LLPEQDKMLVAVKALK-EA-SE-SA--RQDFQ-R-EAELLTML--QHQHIVRFFGVCTE------GRPLLMVFEYMRHGDLNRFLR----SHGPDAKL------------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDI-YS--TDYY-RVGGRTMLPIRWMPPESIL-YRKFTTESDVWSFGVVLWEIFTYGKQPWYQL-SNTEAIDCITQGRELERPRACP------------------------------PEVYAIMRGCWQREPQQRHSIKDVHARL----------------
---F-NFLMVLGKGSFGKVMLSERK-------GTDELYAVKILKKDV-VIQDD---DVECTMVEKRVLALP-GKPPFLTQLHSCFQT------MDRLYFVMEYVNGGDLMYHIQ---QVG----------------------------------------------------------------------RFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKEN--IWDGVTT-KT---FCGTPDYIAPEIIA-YQPYGKSVDWWAFGVLLYEMLA-GQAPFEGE----DEDELFQSIMEHNVAYPKSMS----------------------------KEAVAICKGLMTKHPGKRLGC---------GPEGERDIKEHAFF
---L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-PG-TM-SP---EAFL-Q-EAQVMKKL--RHEKLVQLYAVVS-------EEPIYIVTEYMSKGSLLDFLK----GE-------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--E--DNEY-TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGM-VNREVLDQVERGYRMPCPPECP------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L--------------
-TLE---DKELGSGNFGTVKKGYYQ-----MKKVVKTVAVKILK-NE-AN-DPALKDELL-A-EANVMQQL--DNPYIVRMIGICE-------AESWMLVMEMAELGPLNKYLQ----QN---------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKAL-RA--DENYYKAQTHGKWPVKWYAPECIN-YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGM-KGSEVTAMLEKGERMGCPAGCP------------------------------REMYDLMNLCWTYDVENRPGFAAVE----LRL------------
LIAD----IELGCGNFGSVRQGVYR-----MRKKQIDVAIKVLK-QG-TE-KAD-TEEMM-R-EAQIMHQL--DNPYIVRLIGVCQ-------AEALMLVMEMAGGGPLHKFLV----GK--------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD--DSYY-TARSAGKWPLKWYAPECIN-FRKFSSRSDVWSYGVTMWEALSYGQKPYKKM-KGPEVMAFIEQGKRMECPPECP------------------------------PELYALMSDCWIYKWEDRPDFLTVEQR--M--------------
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