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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK LCK 203
CMGC CDC2 4
TK CSF1R 582
CMGC MAPK14 24
AGC PRKCB 342
TK SYK 371
TK ZAP70 338
----LKLVERLGAGQFGEVWMGYYN------GHTKVAVKSLK-QGSM-SP---DAFL-A-EANLMKQL--QHQRLVRLYAVVT-------QEPIYIITEYMENGSLVDFLK----TP-------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--E--DNEY-TAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNLERGYRMVRPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L--------------
----YTKIEKIGEGTYGVVYKGRHK-----TTGQVVAMKKIRLESEEEGV---PSTAIR-EISLLKEL--RHPNIVSLQDVLMQ------DSRLYLIFEFLSM-DLKKYLDSIPPGQ----------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF--GIPIRVY-TH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP--GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--------------
----LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK-STAH-ADE-KEALM-S-ELKIMSHLG-QHENIVNLLGACTH------GGPVLVITEYCCYGDLLNFLR----RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDI-MN--DSNY-IVKGNARLPVKWMAPESIF-DCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAP------------------------------KNIYSIMQACWALEPTHRPTFQQICSFL----------------
----YQNLSPVGSGAYGSVCAAFDT-----KTGLRVAVKKLSRPFQSIIH---AKRTYR-ELRLLKHM--KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVK----CQ----------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-----HTDDEM-TG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGT-DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF--------------
---F-NFLMVLGKGSFGKVMLSERK-----GTDELYAVKILKKDVVIQDD---DVECTMVEKRVLALP-GKPPFLTQLHSCFQT------MDRLYFVMEYVNGGDLMYHIQ---QVG----------------------------------------------------------------------RFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKEN--IWDGVTT-KT---FCGTPDYIAPEIIA-YQPYGKSVDWWAFGVLLYEMLA-GQAPFEGE----DEDELFQSIMEHNVAYPKSMS----------------------------KEAVAICKGLMTKHPGKRLGC---------GPEGERDIKEHAFF
-TLE---DKELGSGNFGTVKKGYYQ---MKKVVKTVAVKILK-NEAN-DPALKDELL-A-EANVMQQL--DNPYIVRMIGICE-------AESWMLVMEMAELGPLNKYLQ----QN---------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKAL-RA--DENYYKAQTHGKWPVKWYAPECIN-YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGM-KGSEVTAMLEKGERMGCPAGCP------------------------------REMYDLMNLCWTYDVENRPGFAAVE----LRL------------
LIAD----IELGCGNFGSVRQGVYR---MRKKQIDVAIKVLK-QGTE-KAD-TEEMM-R-EAQIMHQL--DNPYIVRLIGVCQ-------AEALMLVMEMAGGGPLHKFLV----GK--------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD--DSYY-TARSAGKWPLKWYAPECIN-FRKFSSRSDVWSYGVTMWEALSYGQKPYKKM-KGPEVMAFIEQGKRMECPPECP------------------------------PELYALMSDCWIYKWEDRPDFLTVEQR--M--------------
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