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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK14 203
TK LCK 245
CMGC MAPK10 64
CMGC MAPK11 24
CMGC MAPK8 26
CMGC MAPK9 26
CMGC NLK 126
AGC RPS6KA3 68
Other STK36 4
---YQNLSPVGSGAYGSVCAAFDTKTGL---RVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVK-CQ---KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR----HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-----AAQALAHAYF
---LKLVERLGAGQFGEVWMGYYN-GHT---KVAVKSLK-QGSM-SPDAFL-AEANLMKQLQHQRLVRLYAVVT-------QEPIYIITEYMENGSLVDFLK-TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI-E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP-----------------------------------------EELYQLMRLCWKERPEDRPT-----FDYLRSV--L
---YQNLKPIGSGAQGIVCAAYDAVLDR---NVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQ--M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART--AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VDDALQHPYI
LQG---LRPVGSGAYGSVCSAYDARLRQ---KVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGA-DLNNIVK-CQ---ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR----QADEEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMP-----------QKDLSSIFRGANPLAIDLLGRMLVLDSDQRVS-----AAEALAHAYF
---YQNLKPIGSGAQGIVCAAYDAILER---NVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDA-NLCQVIQ--M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART--AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDLWSVGCIMGEMVC-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS-----VDEALQHPYI
---YQQLKPIGSGAQGIVCAAFDTVLGI---NVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIH--M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART--ACTNFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGELVK-GCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRIS-----VDEALRHPYI
IEP---DRPIGYGAFGVVWSVTDPRDGK---RVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPH-IDYFEEIYVVTELMQS-DLHKIIVSPQ---PLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQ---EVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLG-RRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQP----------SLPVLYTLSSQATHEAVHLLCRMLVFDPSKRIS-----AKDALAHPYL
---FELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQT------EGKLYLILDFLRGGDLFTRLSKEV---MFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKES-IDHEKKAYS---FCGTVEYMAPEVVN-RRGHTQSADWWSFGVLMFEMLT-GTLPFQGK---DRKETMTMILKAKLGMPQFLS---------------------------------------PEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFF
---YHVLEMIGEGSFGRVYKGRRKYSAQ---VVALKFIPKLGRSEKELRNLQREIEIMRGLRHPNIVHMLDSFET------DKEVVVVTDYAEG-ELFQILEDDG---KLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAM-STNTMVLTS---IKGTPLYMSPELVE-ERPYDHTADLWSVGCILYELAV-GTPPFYAT---SIFQLVSLILKDPVRWPSTIS---------------------------------------PCFKNFLQGLLTKDPRQRLS-----WPDLLYHPFI
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