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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK14 203
TK ABL1 261
TK FGFR1 478
TK FGFR2 481
TK FYN 271
TK LCK 245
TK LYN 247
TK SRC 270
TK YES1 277
-YQNLSPVGSGAYGSVCAAFDT-------KTGLRVAVKKLSRPFQSIIH--AKRTYRELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVKCQ-----------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR----HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF
-ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-EDTM-EV--EEFL-KEAAVMKEI-KHPNLVQLLGVCTR------EPPFYIITEFMTYGNLLDYLREC--------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM-T--GDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F
L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SDAT-EKDLSDLI-SEMEMMKMIGKHKNIINLLGACTQ------DGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHH--IDYYKKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCT------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL--
-LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-DDAT-EKDLSDLV-SEMEMMKMIGKHKNIINLLGACTQ------DGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINN--IDYYKKTTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL--
-LQLIKRLGNGQFGEVWMGTWN--------GNTKVAIKTLK-PGTM-SP--ESFL-EEAQIMKKL-KHDKLVQLYAVVS-------EEPIYIVTEYMNKGSLLDFLKDG--------------EGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLI-E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCP------------------------------ISLHELMIHCWKKDPEERPTFEYLQSFL--
-LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-QGSM-SP--DAFL-AEANLMKQL-QHQRLVRLYAVVT-------QEPIYIITEYMENGSLVDFLKTP--------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI-E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L
-IKLVKRLGAGQFGEVWMGYYN--------NSTKVAVKTLK-PGTM-SV--QAFL-EEANLMKTL-QHDKLVRLYAVVTR------EEPIYIITEYMAKGSLLDFLKSD--------------EGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVI-E--DNEYTAREGAKFPIKWTAPEAIN-FGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCP------------------------------DELYDIMKMCWKEKAEERPTFDYLQSV--L
L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-PGTM-SP--EAFL-QEAQVMKKL-RHEKLVQLYAVVS-------EEPIYIVTEYMSKGSLLDFLKGE--------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI-E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L
L-RLEVKLGQGCFGEVWMGTWN--------GTTKVAIKTLK-PGTM-MP--EAFL-QEAQIMKKL-RHDKLVPLYAVVS-------EEPIYIVTEFMSKGSLLDFLKEG--------------DGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLI-E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCP------------------------------ESLHELMNLCWKKDPDERPTFEYIQSFL--
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