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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK14 203
TK ABL1 261
TK FGFR1 478
CMGC GSK3B 56
TK LCK 245
CMGC MAPK10 64
CMGC MAPK8 26
AGC PDPK1 82
-YQNLSPVGSGAYGSVCAAFDT-------KTGLRVAVKKLSRPFQSIIH--AK-RTYRELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQ-----------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLAR------HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF-----------
-ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-EDTM-EV--EE-FL-KEAAVMKEI-KHPNLVQLLGVCTR------EPPFY--IITEFMTYG--NLLDYLR-----EC--------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLVKVADFGLSRLM---T--GDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP-----------------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F-----------
L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SDAT-EKDLSD-LI-SEMEMMKMIGKHKNIINLLGACTQ------DGPLY--VIVEYASKG--NLREYLQ-----ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-EDNVMKIADFGLARDI-H-H--IDYYKKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCT-----------------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL-------------
-YTDTKVIGNGSFGVVYQAKLC-------DSGELVAIKKVLQDKRFKNR---------ELQIMRKL-DHCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-----------------TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ----LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF-----------
-LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-QGSM-SP--DA-FL-AEANLMKQL-QHQRLVRLYAVVT-------QEPIY--IITEYMENG--SLVDFLK-----TP--------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSCKIADFGLARLI---E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP-----------------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L-----------
-YQNLKPIGSGAQGIVCAAYDA-------VLDRNVAIKKLSRPFQNQTH--AK-RAYRELVLMKCV-NHKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIQ------M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART----AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI-----------
-YQNLKPIGSGAQGIVCAAYDA-------ILERNVAIKKLSRPFQNQTH--AK-RAYRELVLMKCV-NHKNIIGLLNVFTPQKSLEEFQDVY--IVMELMDA---NLCQVIQ------M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART----AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDLWSVGCIMGEMVC-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI-----------
F-KFGKILGEGSFSTVVLAREL-------ATSREYAIKILEKRHIIKEN--KVPYVTRERDVMSRL-DHPFFVKLYFTFQD------DEKLY--FGLSYAKNG--ELLKYIR----KIG-----------------SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHIQITDFGTAKVLS-PESKQARANS---FVGTAQYVSPELLT-EKSACKSSDLWALGCIIYQLVA-GLPPFRAG---NEYLIFQKIIKLEYDFPEKFF---------------------------------------PKARDLVEKLLVLDATKRLGCEEM------EGYGPLKAHPF
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