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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK MERTK 203
TK ALK 1116
TK ERBB3 709
TK FGFR1 478
TK FGFR2 481
TK IGF1R 999
TK INSR 1023
TK MST1R 1082
TK RET 724
STE STK24 24
--L-ILGKILGEGEFGSVMEGNLK----QEDGTSLKVAVKTMKLDNSS-QREIEEFLSEAACMKDF-SHPNVIRLLGVCI-EMSSQGIPKPMVILPFMKYGDLHTYLLYSRL------------------ETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRD---DMTVCVADFGLSKKIYS--GDYY--RQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQ--L--
--I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLP-EVCS-EQDELDFLMEALIISKF-NHQNIVRCIGVSL-QSLP-----RFILLELMAGGDLKSFLRETRP-----------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYR--ASYY--RKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILER--I--
--L-RKLKVLGSGVFGTVHKGVWIP---EGESIKIPVCIKVIE-DKSG-RQSFQAVTDHMLAIGSL-DHAHIVRLLGLCP--GSS-----LQLVTQYLPLGSLLDHVRQH-----------------------RGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKS---PSQVQVADFGVADLLPP--DDKQ--LLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANE--F--
--L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SDAT-EKDLSDLISEMEMMKMIGKHKNIINLLGACT-QDGP-----LYVIVEYASKGNLREYLQARRPPGLEY--------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVMKIADFGLARDIHH--IDYY--KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL----
---LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-DDAT-EKDLSDLVSEMEMMKMIGKHKNIINLLGACT-QDGP-----LYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE---NNVMKIADFGLARDINN--IDYY--KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL----
---ITMSRELGQGSFGMVYEGVAKG--VVKDEPETRVAIKTVN-EAAS-MRERIEFLNEASVMKEF-NCHHVVRLLGVVS-QGQP-----TLVIMELMTRGDLKSYLRSLRPEM--------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE---DFTVKIGDFGMTRDIYE--TDYY--RKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISS--I--
---ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVN-ESAS-LRERIEFLNEASVMKGF-TCHHVVRLLGVVS-KGQP-----TLVVMELMAHGDLKSYLRSLRPEA--------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH---DFTVKIGDFGMTRDIYE--TDYY--RKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL----
THS---DRVIGKGHFGVVYHGEYI----DQAQNRIQCAIKSLS-RITE-MQQVEAFLREGLLMRGL-NHPNVLALIGIMLPPEGL-----PHVLLPYMCHGDLLQFIRSP-----------------------QRNPTVKDLISFGLQVARSMEYLAEQKFVHRDLAARNCMLDE---SFTVKVADFGLARDILD--REYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLV----GEV
--L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-ENAS-PSELRDLLSEFNVLKQV-NHPHVIKLYGACS-QDGP-----LLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE---GRKMKISDFGLSRDVYE--EDSY--VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL----
---FTKLEKIGKGSFGEVFKGIDN-------RTQKVVAIKIIDLEEAEDEI--EDIQQEITVLSQC-DSPYVTKYYGSYL-KDTK-----LWIIMEYLGGGSALDLLEPG-------------------------PLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSE---HGEVKLADFGVAGQL-TDTQIKR--NT---FVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELAR-GEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFI--
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