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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK MET 203
CMGC CDK2 4
TK FGFR1 478
TK FLT4 845
TK PTK2 422
-VHFNEVIGRGHFGCVYHGTLL----DNDGKKIHCAVKSLN-RITD-IGEVSQFL-TEGIIMKDF-SHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIR---NE---------------------------------------------------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYD--KEYYSVHNKTGAKLPVKWMALESLQ-TQKFTTKSDVWSFGVLLWELMTRGAPPYPDV-NTFDITVYLLQGRRLLQPEYCP----------------------------DPLYEVMLKCWHPKAEMRPSFSELVSR--I
-FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLDTETEGV--PSTAIREISLLKEL-NHPNIVKLLDVIH-TENKLYLVFEFLHQ-DLKKFMDASALT-----------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF-GVPVRTY--TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SDAT-EKDLSDLI-SEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKGNLREYLQ---ARRPPGLEY------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHH--IDYY--KKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELFKLLKEGHRMDKPSNCT----------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL--
-LHLGRVLGYGAFGKVVEASAFG--IHKGSSCDTVAVKMLK-EGAT-ASEHRALM-SELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLR---AKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYK--DPDY--VRKGSARLPLKWMAPESIF-DKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELAT----------------------------PAIRRIMLNCWSGDPKARPAFSELVEIL--
-IELGRCIGEGQFGDVHQGIYM----SPENPALAVAIKTCK-NCTS-DSVREKFL-QEALTMRQF-DHPHIVKLIGVIT--ENPVWIIMELCTLGELRSFLQ---VR---------------------------------------------------------------KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYM-E--DSTY--YKASKGKLPIKWMAPESIN-FRRFTSASDVWMFGVCMWEILMHGVKPFQGV-KNNDVIGRIENGERLPMPPNCP----------------------------PTLYSLMTKCWAYDPSRRPRFTELKAQL--
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