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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other NEK2 203
CMGC CDC2 4
CMGC CDC2L6 20
CMGC CDK11A 438
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK6 13
CMGC CDKL2 4
CAMK CHEK1 9
CAMK CHEK2 220
Other CHUK 15
CAMK DAPK3 13
CMGC ICK 4
Other IKBKE 9
CMGC MAK 4
CMGC MAPK14 24
CAMK MARK1 60
Other PLK2 82
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
TK PTK2B 425
Other SBK1 53
STE SLK 34
Other TTK 525
---YEVLYTIGTGSYGRCQKIRRK---SDGK--ILVWKELDYGSMTEAE--KQMLVS------EVNLLREL-K---HPNIVRYYDRIIDR----TNTTLYIVMEYCEGGDLASVITKG---TKERQ--YL--DEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVF--LD----GKQNV----KLGDFGLARIL---NHDTSFAKT---FVGTPYYMSPEQMN-----------RMSYNEKSDIWSLGCLLYELCA-LMPPFTAF--------------SQ-KELAGKIREGKFRRIPYRY---S-------------------------------DELNEIITRMLNLKDYHRPSVEEILENPL-I------------------------------------------------------
---YTKIEKIGEGTYGVVYKGRHK---TTGQ--VVAMKKIRLESEEEGV--PSTAIR------EISLLKEL-R---HPNIVSLQDVLMQ------DSRLYLIFEFLSM-DLKKYLDS----IPPGQ--YM--DSSLVKSYLYQILQGIVFCHSR-----RVLHRDLKPQNLL--ID----DKGTI----KLADFGLARAF---GIPIRVYTH---EVVTLWYRSPEVLL----------GSARYSTPVDIWSIGTIFAELAT-KKPLFHGD-----------SEIDQ-LFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP---------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF-------------------------------------------------------
EGC-----KVGRGTYGHVYKARRK---DGKDEKEYALKQIEGTGISMSA--C----R------EIALLREL-K---HPNVIALQKVFLSH----SDRKVWLLFDYAEH-DLWHIIKFHRASKANKK--PMQLPRSMVKSLLYQILDGIHYLHAN-----WVLHRDLKPANIL--VMGEGPERGRV----KIADMGFARLFNSPLKPLADLDP---VVVTFWYRAPELLL----------GARHYTKAIDIWAIGCIFAELLT-SEPIFHCRQEDI--KTSNPFHHDQ-LDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYF-------------------------------------------------------
---FQCLNRIEEGTYGVVYRAKDK---KTDE--IVALKRLKMEKEKEGF--PITSLR------EINTILKA-Q---HPNIVTVREIVVGS----NMDKIYIVMNYVEH-DLKSLME------TMKQ--PF--LPGEVKTLMIQLLRGVKHLHDN-----WILHRDLKTSNLL--LS----HAGIL----KVGDFGLAREY---GSPLKAYTP---VVVTLWYRAPELLL----------GAKEYSTAVDMWSVGCIFGELLT-QKPLFPGK-----------SEIDQ-INKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPY-------NNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF-------------------------------------------------------
---FQKVEKIGEGTYGVVYKARNK---LTGE--VVALKKIRLDTETEGV--PSTAIR------EISLLKEL-N---HPNIVKLLDVIHT------ENKLYLVFEFLHQ-DLKKFMDA-----SALT--GI--PLPLIKSYLFQLLQGLAFCHSH-----RVLHRDLKPQNLL--IN----TEGAI----KLADFGLARAF---GVPVRTYTH---EVVTLWYRAPEILL----------GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD-----------SEIDQ-LFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-------------------------------------------------------
---FQKVEKIGEGTYGVVYKAKNR---ETGQ--LVALKKIRLDLEMEGV--PSTAIR------EISLLKEL-K---HPNIVRLLDVVHN------ERKLYLVFEFLSQ-DLKKYMDS-----TPGS--EL--PLHLIKSYLFQLLQGVSFCHSH-----RVIHRDLKPQNLL--IN----ELGAI----KLADFGLARAF---GVPLRTYTH---EVVTLWYRAPEILL----------GSKFYTTAVDIWSIGCIFAEMVT-RKALFPGD-----------SEIDQ-LFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR---------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF-------------------------------------------------------
---YECVAEIGEGAYGKVFKARDL---KNGG-RFVALKRVRVQTGEEGM--PLSTIR------EVAVLRHL-ETFEHPNVVRLFDVCTVSR-TDRETKLTLVFEHVDQ-DLTTYLDK-----VPEP--GV--PTETIKDMMFQLLRGLDFLHSH-----RVVHRDLKPQNIL--VT----SSGQI----KLADFGLARI----YSFQMALTS---VVVTLWYRAPEVLL-----------QSSYATPVDLWSVGCIFAEMFR-RKPLFRGS-----------SDVDQ-LGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ-----------PIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF-------------------------------------------------------
---YENLGLVGEGSYGMVMKCRNK---DTGR--IVAIKKFLESDDDKMV--KKIAMR------EIKLLKQL-R---HENLVNLLEVCKK------KKRWYLVFEFVDHTILDDLEL-------FPN--GL--DYQVVQKYLFQIINGIGFCHSH-----NIIHRDIKPENIL--VS----QSGVV----KLCDFGFARTL---AAPGEVYTD---YVATRWYRAPELLV----------GDVKYGKAVDVWAIGCLVTEMFM-GEPLFPGD-----------SDIDQ-LYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKE-------REPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFF-------------------------------------------------------
--W-DLVQTLGEGAYGEVQLAVNR---VTEE--AVAVKIVDMKRAVDCP--ENI-KK------EICINKML-N---HENVVKFYGHRRE------GNIQYLFLEYCSGGELFDRIE-------PDI--GM--PEPDAQRFFHQLMAGVVYLHGI-----GITHRDIKPENLL--LD----ERDNL----KISDFGLATVFR-YNNRERLLNK---MCGTLPYVAPELLK----------RREFHAEPVDVWSCGIVLTAMLA-GELPWDQP-------------SDS-CQEYSDWKEKKTYLNPWKKI--D-------------------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y------------------------------------------------------
-YI--MSKTLGSGACGEVKLAFER---KTCK--KVAIKIISKRKFAIGS--AREADPALNVETEIEILKKL-N---HPCIIKIKNFF-D------AEDYYIVLELMEGGELFDKVV-------GNK--RL--KEATCKLYFYQMLLAVQYLHEN-----GIIHRDLKPENVL--LS----SQEEDC-LIKITDFGHSKI----LGETSLMRT---LCGTPTYLAPEVLVS--------VGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH-------------RTQ-VSLKDQITSGKYNFIPEVWAEVS-------------------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL-------------------------------------------------------
--W-EMRERLGTGGFGNVCLYQHR---ELDL--KIAIKSCRLELSTKNR--ER-WCH------EIQIMKKL-N---HANVVKACDVPEELN-ILIHDVPLLAMEYCSGGDLRKLLNK----PENCC--GL--KESQILSLLSDIGSGIRYLHEN-----KIIHRDLKPENIV--LQ----DVGGKI-IHKIIDLGYAKD----VDQGSLCTS---FVGTLQYLAPELFE-----------NKPYTATVDYWSFGTMVFECIA-GYRPFLHHLQPFTWHEKIKKKDPK-CIFACEEMSGEVRFSSHLPQPNSLCS-------------------------LVVEPMENWLQLMLNWDPQQRG-----------GPVDLTLKQ----------------------------------------------
---YEMGEELGSGQFAIVRKCRQK---GTGK--EYAAKFIKKRRLSSSR--RGVSREEI--EREVNILREI-R---HPNIITLHDIFEN------KTDVVLILELVSGGELFDFLA-------EKE--SL--TEDEATQFLKQILDGVHYLHSK-----RIAHFDLKPENIM--LL----DKNVPNPRIKLIDFGIAHK----IEAGNEFKN---IFGTPEFVAPEIVN-----------YEPLGLEADMWSIGVITYILLS-GASPFLGE--------------TK-QETLTNISAVNYDFDEEYFSNTS-------------------------------ELAKDFIRRLLVKDPKRRMTIAQSLEHSWI-------------------------------------------------------
---YTTIRQLGDGTYGSVLLGRSI---ESGE--LIAIKKMKRKFYSWEE--C-MNLR------EVKSLKKL-N---HANVVKLKEVIRE------NDHLYFIFEYMKE-NLYQLIK------ERNK--LF--PESAIRNIMYQILQGLAFIHKH-----GFFHRDLKPENLL--CM----GPELV----KIADFGLARE----IRSKPPYTD---YVSTRWYRAPEVLL----------RSTNYSSPIDVWAVGCIMAEVYT-LRPLFPGA-----------SEIDT-IFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCV--------PNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYF-------------------------------------------------------
--W-HTDDLLGQGATASVYKARNK---KSGE--LVAVKVFNTTSYLRPR--EV-QVR------EFEVLRKL-N---HQNIVKLFAVEETG----GSRQKVLVMEYCSSGSLLSVLES----PENAF--GL--PEDEFLVVLRCVVAGMNHLREN-----GIVHRDIKPGNIMRLVG----EEGQSI--YKLTDFGAARE----LDDDEKFVS---VYGTEEYLHPDMYERAV---LRKPQQKAFGVTVDLWSIGVTLYHAAT-GSLPFIPF----------GGPRRN-KEIMYRITTEKPAGAIA-------------------------------------------------------------------GAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFAET
---YTTMRQLGDGTYGSVLMGKSN---ESGE--LVAIKRMKRKFYSWDE--CM-NLR------EVKSLKKL-N---HANVIKLKEVIRE------NDHLYFIFEYMKE-NLYQLMK------DRNK--LF--PESVIRNIMYQILQGLAFIHKH-----GFFHRDMKPENLL--CM----GPELV----KIADFGLARE----LRSQPPYTD---YVSTRWYRAPEVLL----------RSSVYSSPIDVWAVGSIMAELYM-LRPLFPGT-----------SEVDE-IFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCV--------PINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYF-------------------------------------------------------
---YQNLSPVGSGAYGSVCAAFDT---KTGL--RVAVKKLSRPFQSIIH--AKRTYR------ELRLLKHM-K---HENVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVK--------CQ--KL--TDDHVQFLIYQILRGLKYIHSA-----DIIHRDLKPSNLA--VN----EDCEL----KILDFGLAR------HTDDEMTG---YVATRWYRAPEIML----------NWMHYNQTVDIWSVGCIMAELLT-GRTLFPGT-----------DHIDQ-LKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF-------------------------------------------------------
---YRLQKTIGKGNFAKVKLARHV---LTGR--EVAVKIIDKTQLNPTS--LQKLFR------EVRIMKIL-N---HPNIVKLFEVIET------EKTLYLVMEYASGGEVFDYLV-------AHG--RM--KEKEARAKFRQIVSAVQYCHQK-----YIVHRDLKAENLL--LD----GDMNI----KIADFGFSNE----FTVGNKLDT---FCGSPPYAAPELFQ----------GKKYDGPEVDVWSLGVILYTLVS-GSLPFDGQ--------------NL-KELRERVLRGKYRIPFYMS-----------------------------------TDCENLLKKLLVLNPIKRGSLEQIMKDRWM-------------------------------------------------------
--Y-CRGKVLGKGGFAKCYEMTDL---TNNK--VYAAKIIPHSRVAKPH--QREKID-----KEIELHRIL-H---HKHVVQFYHYFED------KENIYILLEYCSRRSMAHILK-------ARK--VL--TEPEVRYYLRQIVSGLKYLHEQ-----EILHRDLKLGNFF--IN----EAMEL----KVGDFGLAARL---EPLEHRRRT---ICGTPNYLSPEVLN-----------KQGHGCESDIWALGCVMYTMLL-GRPPFETT--------------NL-KETYRCIREARYTMPSSLL-----------------------------------APAKHLIASMLSKNPEDRPSLDDIIRHDFF-------------------------------------------------------
-PD----EVLGSGQFGIVYGGKHR---KTGR--DVAIKIIDKLRFPTKQ--ESQLRN------EVAILQNL-H---HPGVVNLECMFET------PERVFVVMEKLHGDMLEMILS------SEKG--RL--PEHITKFLITQILVALRHLHFK-----NIVHCDLKPENVL--LA----SADPFP-QVKLCDFGFARI----IGEKSFRRS---VVGTPAYLAPEVLR-----------NKGYNRSLDMWSVGVIIYVSLS-GTFPFNED-----------------EDIHDQIQNAAFMYPPNPWKEIS-------------------------------HEAIDLINNLLQVKMRKRYSVDKTLSHPWL-------------------------------------------------------
-PD----EVLGSGQFGVVYGGKHR---KTGR--DVAVKVIDKLRFPTKQ--ESQLRN------EVAILQSL-R---HPGIVNLECMFET------PEKVFVVMEKLHGDMLEMILS------SEKG--RL--PERLTKFLITQILVALRHLHFK-----NIVHCDLKPENVL--LA----SADPFP-QVKLCDFGFARI----IGEKSFRRS---VVGTPAYLAPEVLL-----------NQGYNRSLDMWSVGVIMYVSLS-GTFPFNED-----------------EDINDQIQNAAFMYPASPWSHIS-------------------------------AGAIDLINNLLQVKMRKRYSVDKSLSHPWL-------------------------------------------------------
FAD----EVLGSGQFGIVYGGKHR---KTGR--DVAIKVIDKMRFPTKQ--ESQLRN------EVAILQNL-H---HPGIVNLECMFET------PERVFVVMEKLHGDMLEMILS------SEKS--RL--PERITKFMVTQILVALRNLHFK-----NIVHCDLKPENVL--LA----SAEPFP-QVKLCDFGFARI----IGEKSFRRS---VVGTPAYLAPEVLR-----------SKGYNRSLDMWSVGVIIYVSLS-GTFPFNED-----------------EDINDQIQNAAFMYPPNPWREIS-------------------------------GEAIDLINNLLQVKMRKRYSVDKSLSHPWL-------------------------------------------------------
--V-VLNRILGEGFFGEVYEGVYTNHKGEKI--NVAVKTCK-KDCT-LDNKEKFM-S------EAVIMKNL-D---HPHIVKLIGIIE-------EEPTWIIMELYPYGELGHYLE--------RNKNSL--KVLTLVLYSLQICKAMAYLESI-----NCVHRDIAVRNIL--VA----SPECV----KLGDFGLSRYI---E--DEDYYKASVTRLPIKWMSPESIN-----------FRRFTTASDVWMFAVCMWEILSFGKQPFFWL-----------ENKDV-IGVLEKGDRLPKPDLCP-------------------------------------PVLYTLMTRCWDYDPSDRPRFTELVCS--L-------------------------------------------------------
---YELVRELGKGTYGKVDLVVYK---GTGT--KMALKFVNKSKTKLKN--F---LR------EVSITNSLSS---SPFIIKVFDVVFE-----TEDCYVFAQEYAPAGDLFDIIP-------PQV--GL--PEDTVKRCVQQLGLALDFMHGR-----QLVHRDIKPENVL--LFD--RECRRV----KLADFGMTR------RVGCRVKR---VSGTIPYTAPEVCQAG------RADGLAVDTGVDVWAFGVLIFCVLT-GNFPWEAA-----------SGADAFFEEFVRWQRGRLPGLPSQWRRFT-------------------------------EPALRMFQRLLALEPERRGPAKEVF-----RFLKH--------------------------------------------------
---WEIIGELGDGAFGKVYKAQNK---ETSV--LAAAKVIDTKSEEELE--DYM--V------EIDILASC-D---HPNIVKLLDAFYY------ENNLWILIEFCAGGAVDAVML------ELER--PL--TESQIQVVCKQTLDALNYLHDN-----KIIHRDLKAGNIL--FT----LDGDI----KLADFGVSAKN---TRTIQRRDS---FIGTPYWMAPEVVMCE------TSKDRPYDYKADVWSLGITLIEMAE-IEPPHHEL-----------NPMRV-LLKIAKSEPPTLAQPSRWS-----------------------------------SNFKDFLKKCLEKNVDARWTTSQLLQHPFV-------------------------------------------------------
---YSILKQIGSGGSSKVFQVLNE---KKQ---IYAIKYVNLEEADNQT--LDSYRN------EIAYLNKLQQ--HSDKIIRLYDYEIT------DQYIYMVMECGNI-DLNSWLK-------KKK--SI--DPWERKSYWKNMLEAVHTIHQH-----GIVHSDLKPANFL--IV-----DGML----KLIDFGIANQMQ-PDTTSVVKDS---QVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTY-GKTPFQQI-------------INQ-ISKLHAIIDPNHEIEFPDIPE---------------------------------KDLQDVLKCCLKRDPKQRISIPELLAHPYV-------------------------------------------------------
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