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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other NEK2 203
CMGC CDK2 4
CAMK DAPK3 13
Other IKBKE 9
Other NEK1 4
Other NEK5 4
Other NEK9 52
Other PLK1 53
Other PLK2 82
Other PLK3 62
CAMK PRKD3 576
STE SLK 34
---YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVS----EVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVF--LDGKQNV----KLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMN--------RMSYNEKSDIWSLGCLLYELCALMPPFTAF----SQKELAGKIREGKFRRIPYRY---S----------------------DELNEIITRMLNLKDYHRPSVEEILENPL-I------------------------------------------------------
---FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR----EISLLKELNHPNIVKLLDVIHT--ENKLYLVFEFLHQ-DLKKFMDA--SALTGIPLPLIKSYLFQLLQGLAFCHSH-----RVLHRDLKPQNLL--INTEGAI----KLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL-------GCKYYSTAVDIWSLGCIFAEMVTRRALFPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-------------------------------------------------------
---YEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIRHPNIITLHDIFEN--KTDVVLILELVSGGELFDFLA----EKESLTEDEATQFLKQILDGVHYLHSK-----RIAHFDLKPENIM--LLDKNVPNPRIKLIDFGIAHK-IEAGNEFKNIFGTPEFVAPEIVN--------YEPLGLEADMWSIGVITYILLSGASPFLGE----TKQETLTNISAVNYDFDEEYFSNTS----------------------ELAKDFIRRLLVKDPKRRMTIAQSLEHSWI-------------------------------------------------------
--W-HTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREV-QVR----EFEVLRKLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLES-PENAFGLPEDEFLVVLRCVVAGMNHLREN-----GIVHRDIKPGNIMRLVGEEGQSI--YKLTDFGAARE-LDDDEKFVSVYGTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTEKPAGAIA----------------------------------------------------------GAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFAET
--Y-VRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRR----EVAVLANMKHPNIVQYRESFEE--NGSLYIVMDYCEGGDLFKRINA--QKGVLFQEDQILDWFVQICLALKHVHDR-----KILHRDIKSQNIF--LTKDGTV----QLGDFGIARVLNSTVELARTCIGTPYYLSPEICE--------NKPYNNKSDIWALGCVLYELCTLKHAFEAG----SMKNLVLKIISGSFPPVSLHYS-------------------------YDLRSLVSQLFKRNPRDRPSVNSILEKGF-I------------------------------------------------------
---YDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKK----EVILLEKMKHPNIVAFFNSFQE--NGRLFIVMEYCDGGDLMKRINR--QRGVLFSEDQILGWFVQISLGLKHIHDR-----KILHRDIKAQNIF--LSKNGMV---AKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQ--------NKPYNNKTDIWSLGCVLYELCTLKHPFEGN----NLQQLVLKICQAHFAPISPGF---S----------------------RELHSLISQLFQVSPRDRPSINSILKRPFL-------------------------------------------------------
YIP---IRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALN----EIVILALLQHDNIIAYYNHFMD--NTTLLIELEYCNGGNLYDKILR--QKDKLFEEEMVVWYLFQIVSAVSCIHKA-----GILHRDIKTLNIF--LTKANLI----KLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQ--------GVKYNFKSDIWAVGCVIFELLTLKRTFDAT----NPLNLCVKIVQGIRAMEVDSS-QYS----------------------LELIQMVHSCLDQDPEQRPTADELLDRPL-L------------------------------------------------------
-YV--RGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMS---MEISIHRSLAHQHVVGFHGFFED--NDFVFVVLELCRRRSLLELHK----RRKALTEPEARYYLRQIVLGCQYLHRN-----RVIHRDLKLGNLF--LNEDLEV----KIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLS--------KKGHSFEVDVWSIGCIMYTLLVGKPPFETS----CLKETYLRIKKNEYSIPKHIN--------------------------PVAASLIQKMLQTDPTARPTINELLNDEFF-------------------------------------------------------
--Y-CRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKID---KEIELHRILHHKHVVQFYHYFED--KENIYILLEYCSRRSMAHILK----ARKVLTEPEVRYYLRQIVSGLKYLHEQ-----EILHRDLKLGNFF--INEAMEL----KVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLN--------KQGHGCESDIWALGCVMYTMLLGRPPFETT----NLKETYRCIREARYTMPSSLL--------------------------APAKHLIASMLSKNPEDRPSLDDIIRHDFF-------------------------------------------------------
-YL--KGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKIL---NEIELHRDLQHRHIVRFSHHFED--ADNIYIFLELCSRKSLAHIWK----ARHTLLEPEVRYYLRQILSGLKYLHQR-----GILHRDLKLGNFF--ITENMEL----KVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL--------RQGHGPEADVWSLGCVMYTLLCGSPPFETA----DLKETYRCIKQVHYTLPASLS--------------------------LPARQLLAAILRASPRDRPSIDQILRHDFF-------------------------------------------------------
FAD----EVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRN----EVAILQNLHHPGIVNLECMFET--PERVFVVMEKLHGDMLEMILS---SEKSRLPERITKFMVTQILVALRNLHFK-----NIVHCDLKPENVL--LASAEPFP-QVKLCDFGFARI-IGEKSFRRSVVGTPAYLAPEVLR--------SKGYNRSLDMWSVGVIIYVSLSGTFPFNED------EDINDQIQNAAFMYPPNPWREIS----------------------GEAIDLINNLLQVKMRKRYSVDKSLSHPWL-------------------------------------------------------
---WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYM--V----EIDILASCDHPNIVKLLDAFYY--ENNLWILIEFCAGGAVDAVML---ELERPLTESQIQVVCKQTLDALNYLHDN-----KIIHRDLKAGNIL--FTLDGDI----KLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCE---TSKDRPYDYKADVWSLGITLIEMAEIEPPHHEL-NPMRVLLKIAKSEPPTLAQPSRWS--------------------------SNFKDFLKKCLEKNVDARWTTSQLLQHPFV-------------------------------------------------------
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