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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK NTRK3 203
TK ABL1 261
TK BMX 422
TKL BRAF 456
TK CSF1R 582
TK EPHA3 621
TK FGFR1 478
TK FLT1 827
TK INSR 1023
TK KDR 834
TK KIT 589
TK LCK 245
CMGC MAPK14 24
TK PDGFRA 593
TK PDGFRB 600
TK TEK 824
I-VLKRELGEGAFGKVFLAECYN--LSPTKDKMLVAVKALK-D-PTL-AA-RKDFQ-REAELLTNL-QHEHIVKFYGVCG-D------GDPLIMVFEYMKHGDLNKFLRAHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYS--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-YRK---FTTESDVWSFGVILWEIFTYGKQPWFQL-SNTEVIECITQGRV----LERPRVCP------------------------------KEVYDVMLGCWQREPQQRLNIKEIYKIL---
-ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-E-DTM-EV--EEFL-KEAAVMKEI-KHPNLVQLLGVCT-R------EPPFYIITEFMTYGNLLDYLREC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM-T--GDTY--------------TAHAGAKFPIKWTAPESLA-YNK---FSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELLEKDYR----MERPEGCP------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F-
-ITLLKELGSGQFGVVQLGKWK--------GQYDVAVKMIK-E-GSM-SE--DEFF-QEAQTMMKL-SHPKLVKFYGVCS-K------EYPIYIVTEYISNGCLLNYLRSH--------------------------------------------------------------------------------------------------GKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYV-L--DDQY--------------VSSVGTKFPVKWSAPEVFH-YFK---YSSKSDVWAFGILMWEVFSLGKQPYDLY-DNSQVVLKVSQGHR----LYRPHLAS------------------------------DTIYQIMYSCWHELPEKRPTFQQLLSS--I-
-ITVGQRIGSGSFGTVYKGKWH----------GDVAVKMLN-VTAPT-PQQLQAFK-NEVGVLRKT-RHVNILLFMGYST--------KPQLAIVTQWCEGSSLYHHLHII--------------------------------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSR--WSGS--------------HQFEQLSGSILWMAPEVIR-MQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCP------------------------------KAMKRLMAECLKKKRDERPLFPQILA---SI
-LQFGKTLGAGAFGKVVEATAFG--LGKEDAVLKVAVKMLK-S-TAH-ADEKEALM-SELKIMSHLGQHENIVNLLGACT-H------GGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMN--DSNY--------------IVKGNARLPVKWMAPESIF-DCV---YTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQ----MAQPAFAP------------------------------KNIYSIMQACWALEPTHRPTFQQICSFL---
I-SIDKVVGAGEFGEVCSGRLK----LPSKKEISVAIKTLK-V-GYT-EKQRRDFL-GEASIMGQF-DHPNIIRLEGVVT-K------SKPVMIVTEYMENGSLDSFLRKH--------------------------------------------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLED--DPEA-------------AYTTRGGKIPIRWTSPEAIA-YRK---FTSASDVWSYGIVLWEVMSYGERPYWEM-SNQDVIKAVDEGYR----LPPPMDCP------------------------------AALYQLMLDCWQKDRNNRPKFEQIVSIL---
L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-S-DAT-EKDLSDLI-SEMEMMKMIGKHKNIINLLGACT-Q------DGPLYVIVEYASKGNLREYLQARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHH--IDYY--------------KKTTNGRLPVKWMAPEALF-DRI---YTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELFKLLKEGHR----MDKPSNCT------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL---
-LKLGKSLGRGAFGKVVQASAFG--IKKSPTCRTVAVKMLK-E-GAT-ASEYKALM-TELKILTHIGHHLNVVNLLGACTKQ------GGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPR--------------------------------LDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYK--NPDY--------------VRKGDTRLPLKWMAPESIF-DKI---YSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMR----MRAPEYST------------------------------PEIYQIMLDCWHRDPKERPRFAELVEKL---
-ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVN-E-SAS-LRERIEFL-NEASVMKGF-TCHHVVRLLGVVS-K------GQPTLVVMELMAHGDLKSYLRSLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYE--TDYY--------------RKGGKGLLPVRWMAPESLK-DGV---FTTSSDMWSFGVVLWEITSLAEQPYQGL-SNEQVLKFVMDGGY----LDQPDNCP------------------------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL---
-LKLGKPLGRGAFGQVIEADAFG--IDKTATCRTVAVKMLK-E-GAT-HSEHRALM-SELKILIHIGHHLNVVNLLGACTKP------GGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYK--DPDY--------------VRKGDARLPLKWMAPETIF-DRV---YTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTR----MRAPDYTT------------------------------PEMYQTMLDCWHGEPSQRPTFSELVEHL---
-LSFGKTLGAGAFGKVVEATAYG--LIKSDAAMTVAVKMLK-P-SAH-LTEREALM-SELKVLSYLGNHMNIVNLLGACT-I------GGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKN--DSNY--------------VVKGNARLPVKWMAPESIF-NCV---YTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFR----MLSPEHAP------------------------------AEMYDIMKTCWDADPLKRPTFKQIVQL--I-
-LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-Q-GSM-SP--DAFL-AEANLMKQL-QHQRLVRLYAVVT--------QEPIYIITEYMENGSLVDFLKTP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI-E--DNEY--------------TAREGAKFPIKWTAPEAIN-YGT---FTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNLERGYR----MVRPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L-
-YQNLSPVGSGAYGSVCAAFDT-------KTGLRVAVKKLSRP-FQSIIH--AKRTYRELRLLKHM-KHENVIGLLDVFT-PARSLEEFNDVYLVTHLMGA-DLNNIVKCQ----------------------------------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR----HTDDEM--------------TG---YVATRWYRAPEIMLNWMH---YNQTVDIWSVGCIMAELLT-GRTLFPGT-DHIDQLKLILRLVG----TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF-
L-VLGRVLGSGAFGKVVEGTAYG--LSRSQPVMKVAVKMLK-P-TAR-SSEKQALM-SELKIMTHLGPHLNIVNLLGACT-K------SGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMH--DSNY--------------VSKGSTFLPVKWMAPESIF-DNL---YTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYR----MAKPDHAT------------------------------SEVYEIMVKCWNSEPEKRPSFYHLSE---IV
L-VLGRTLGSGAFGQVVEATAHG--LSHSQATMKVAVKMLK-S-TAR-SSEKQALM-SELKIMSHLGPHLNVVNLLGACT-K------GGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMR--DSNY--------------ISKGSTFLPLKWMAPESIF-NSL---YTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYR----MAQPAHAS------------------------------DEIYEIMQKCWEEKFEIRPPFSQLVL---LL
-IKFQDVIGEGNFGQVLKARIK-----KDGLRMDAAIKRMK-E-YAS-KDDHRDFA-GELEVLCKLGHHPNIINLLGACE-H------RGYLYLAIEYAPHGNLLDFLRKSRVLETDP-----------------------------------------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ-----EVY--------------VKKTMGRLPVRWMAIESLN-YSV---YTTNSDVWSYGVLLWEIVSLGGTPYCGM-TCAELYEKLPQGYR----LEKPLNCD------------------------------DEVYDLMRQCWREKPYERPSFAQILV---SL
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