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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK NTRK3 203
TK ABL1 261
TK ABL2 288
Other AURKA 133
TK BMX 422
TK BTK 402
CMGC CDC2 4
CMGC CDK2 4
Other CHUK 15
TK CSF1R 582
CAMK DAPK1 13
TK EGFR 712
Other EIF2AK2 267
TK FGFR1 478
TK FYN 271
TK INSR 1023
TK INSRR 979
TKL IRAK4 186
TK ITK 363
TK JAK2 849
TK KIT 589
TK LCK 245
CMGC MAPK14 24
TK NTRK1 510
TK NTRK2 538
CAMK NUAK1 55
TK PDGFRB 600
TKL RAF1 349
TK RET 724
TK ROS1 1945
TK SRC 270
TK SYK 371
TKL TGFBR1 205
TK TNK2 150
TK TXK 271
TK YES1 277
--I-VLKRELGEGAFGKVFLAECYN--LSPTKDKMLVAVKALK-D--P-TL-AA--RK-DFQ-R----EAELLTNL-QHEHIVKFYGVCG--D-----------------------------GDPLIMVFEYMKHGDLNKFLR----AHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQ--------HFVHRDLATRNCLVGA-----NLLV----KIGDFGMSRDV---Y--S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM------YRK---FTTESDVWSFGVILWEIFTYGK----------QP---------------WFQL-----------SNTEVIECI-TQGRV----LERPRVCP------------------------------KEVYDVMLGCWQREPQQRLNIKEIYKIL-----------
---ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-E--D-TM-EV---E-EFL-K----EAAVMKEI-KHPNLVQLLGVCT--R-----------------------------EPPFYIITEFMTYGNLLDYLR----EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVGE-----NHLV----KVADFGLSRLM------T--GDTY--------------TAHAGAKFPIKWTAPESLA------YNK---FSIKSDVWAFGVLLWEIATYGM----------SP---------------YPGI-----------DLSQVYELL-EKDYR----MERPEGCP------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F---------
---ITMKHKLGGGQYGEVYVGVWK-------KYSLTVAVKTLK-E--D-TM-EV---E-EFL-K----EAAVMKEI-KHPNLVQLLGVCT--L-----------------------------EPPFYIVTEYMPYGNLLDYLR----EC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVGE-----NHVV----KVADFGLSRLM------T--GDTY--------------TAHAGAKFPIKWTAPESLA------YNT---FSIKSDVWAFGVLLWEIATYGM----------SP---------------YPGI-----------DLSQVYDLL-EKGYR----MEQPEGCP------------------------------PKVYELMRACWKWSPADRPSFAETHQA--F---------
---FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKA--QLEKAGV---E-HQLRR----EVEIQSHL-RHPNILRLYGYFH--D-----------------------------ATRVYLILEYAPLGTVYRELQ---KLS----------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSK--------RVIHRDIKPENLLLGS-----AGEL----KIADFGWSV--------HAPSSRR--------------TT---LCGTLDYLPPEMIE------GRM---HDEKVDLWSLGVLCYEFLV-GK----------PP---------------FEAN--------------TYQETY-KRISR----VEFTFPDFVT----------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI---------
---ITLLKELGSGQFGVVQLGKWK--------GQYDVAVKMIK-E--G-SM-SE---D-EFF-Q----EAQTMMKL-SHPKLVKFYGVCS--K-----------------------------EYPIYIVTEYISNGCLLNYLR----SH--------------------------------------------------------------------------------------------------GKGLEPSQLLEMCYDVCEGMAFLESH--------QFIHRDLAARNCLVDR-----DLCV----KVSDFGMTRYV------L--DDQY--------------VSSVGTKFPVKWSAPEVFH------YFK---YSSKSDVWAFGILMWEVFSLGK----------QP---------------YDLY-----------DNSQVVLKV-SQGHR----LYRPHLAS------------------------------DTIYQIMYSCWHELPEKRPTFQQLLSS--I---------
---LTFLKELGTGQFGVVKYGKWR--------GQYDVAIKMIK-E--G-SM-SE---D-EFI-E----EAKVMMNL-SHEKLVQLYGVCT--K-----------------------------QRPIFIITEYMANGCLLNYLR----EM--------------------------------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESK--------QFLHRDLAARNCLVND-----QGVV----KVSDFGLSRYV------L--DDEY--------------TSSVGSKFPVRWSPPEVLM------YSK---FSSKSDIWAFGVLMWEIYSLGK----------MP---------------YERF-----------TNSETAEHI-AQGLR----LYRPHLAS------------------------------EKVYTIMYSCWHEKADERPTFKILLSN--I---------
---YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKIRLE--S-EEEGV---P-STAIR----EISLLKEL-RHPNIVSLQDVLM--Q-----------------------------DSRLYLIFEFLSM-DLKKYLDSIPPGQ----------------------------------------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHSR--------RVLHRDLKPQNLLIDD-----KGTI----KLADFGLARAF------GIPIRVY--------------TH---EVVTLWYRSPEVLL-----GSAR---YSTPVDIWSIGTIFAELAT-KK----------PL---------------FHGD-----------SEIDQLFRI-FRALG----TPNNEVWPEVESLQDYKNTFPKWKP--GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF---------
---FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLD--T-ETEGV---P-STAIR----EISLLKEL-NHPNIVKLLDVIH--T-----------------------------ENKLYLVFEFLHQ-DLKKFMDA-SALT----------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSH--------RVLHRDLKPQNLLINT-----EGAI----KLADFGLARAF------GVPVRTY--------------TH---EVVTLWYRAPEILL-----GCKY---YSTAVDIWSLGCIFAEMVT-RR----------AL---------------FPGD-----------SEIDQLFRI-FRTLG----TPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF---------
--W-EMRERLGTGGFGNVCLYQHR-------ELDLKIAIKSCRLE--L-STKNR---E-R-WCH----EIQIMKKL-NHANVVKACDVPE--ELN------------------------ILIHDVPLLAMEYCSGGDLRKLLNKPENCC----------------------------------------------------------------------------------------------------GLKESQILSLLSDIGSGIRYLHEN--------KIIHRDLKPENIVLQD-----VGGKI-IHKIIDLGYAKD-------VDQGSLC--------------TS---FVGTLQYLAPELFE------NKP---YTATVDYWSFGTMVFECIA-GY----------RP---------------FLHHLQPFTWHEKIKKKDPKCIFA-CEEMS----GEVRFSSHLPQPNSLCS------------------LVVEPMENWLQLMLNWDPQQRG-----------GPVDLTLKQ
---LQFGKTLGAGAFGKVVEATAFG--LGKEDAVLKVAVKMLK-S--T-AH-ADE-KE-ALM-S----ELKIMSHLGQHENIVNLLGACT--H-----------------------------GGPVLVITEYCCYGDLLNFLR----RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASK--------NCIHRDVAARNVLLTN-----GHVA----KIGDFGLARDI---M--N--DSNY--------------IVKGNARLPVKWMAPESIF------DCV---YTVQSDVWSYGILLWEIFSLGL----------NP---------------YPGI-L---------VNSKFYKLV-KDGYQ----MAQPAFAP------------------------------KNIYSIMQACWALEPTHRPTFQQICSFL-----------
---YDTGEELGSGQFAVVKKCREK-------STGLQYAAKFIKKR--R-TKSSR---R-GVSREDIEREVSILKEI-QHPNVITLHEVYE--N-----------------------------KTDVILILELVAGGELFDFLA---EKE----------------------------------------------------------------------------------------------------SLTEEEATEFLKQILNGVYYLHSL--------QIAHFDLKPENIMLLD-----RNVPKPRIKIIDFGLAHK-------IDFGNEF--------------KN---IFGTPEFVAPEIVN------YEP---LGLEADMWSIGVITYILLS-GA----------SP---------------FLGD--------------TKQETL-ANVSA----VNYEFEDEYFSNTS------------------------ALAKDFIRRLLVKDPKKRMTIQDSLQHPWI---------
--F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-E--A-TS-PKA-NK-EIL-D----EAYVMASV-DNPHVCRLLGICL--------------------------------TSTVQLITQLMPFGCLLDYVR----EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDR--------RLVHRDLAARNVLVKT-----PQHV----KITDFGLAKLL---G--A--EEKE--------------YHAEGGKVPIKWMALESIL------HRI---YTHQSDVWSYGVTVWELMTFGS----------KP---------------YDGI-----------PASEISSIL-EKGER----LPQPPICT------------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF-------
--F-KEIELIGSGGFGQVFKAKHR-------IDGKTYVIKRVKYN--N-EKAER--------------EVKALAKL-DHVNIVHYNGCWD--GFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEK-RRGE----------------------------------------------------------------------------------------------------KLDKVLALELFEQITKGVDYIHSK--------KLIHRDLKPSNIFLVD-----TKQV----KIGDFGLVTS-------LKNDGKR--------------TR---SKGTLRYMSPEQIS------SQD---YGKEVDLYALGLILAELLH-VC---------DTA---------------FET------------------SKF-FTDLR----DGIISDIFDK-----------------------------KEKTLLQKLLSKKPEDRPNTSEILR----TLT------
--L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-S--D-AT-EKD-LS-DLI-S----EMEMMKMIGKHKNIINLLGACT--Q-----------------------------DGPLYVIVEYASKGNLREYLQ----ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK--------KCIHRDLAARNVLVTE-----DNVM----KIADFGLARDI---H--H--IDYY--------------KKTTNGRLPVKWMAPEALF------DRI---YTHQSDVWSFGVLLWEIFTLGG----------SP---------------YPGV-----------PVEELFKLL-KEGHR----MDKPSNCT------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL-----------
---LQLIKRLGNGQFGEVWMGTWN--------GNTKVAIKTLK-P--G-TM-SP---E-SFL-E----EAQIMKKL-KHDKLVQLYAVVS--------------------------------EEPIYIVTEYMNKGSLLDFLK----DG-------------------------------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERM--------NYIHRDLRSANILVGN-----GLIC----KIADFGLARLI------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILLTELVTKGR----------VP---------------YPGM-----------NNREVLEQV-ERGYR----MPCPQDCP------------------------------ISLHELMIHCWKKDPEERPTFEYLQSFL-----------
---ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVN-E--S-AS-LRE-RI-EFL-N----EASVMKGF-TCHHVVRLLGVVS--K-----------------------------GQPTLVVMELMAHGDLKSYLR----SLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAK--------KFVHRDLAARNCMVAH-----DFTV----KIGDFGMTRDI---Y--E--TDYY--------------RKGGKGLLPVRWMAPESLK------DGV---FTTSSDMWSFGVVLWEITSLAE----------QP---------------YQGL-----------SNEQVLKFV-MDGGY----LDQPDNCP------------------------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL-----------
--I-SIIRELGQGSFGMVYEGLARG--LEAGEESTPVALKTVN-E--L-AS-PRE-CI-EFL-K----EASVMKAF-KCHHVVRLLGVVS--Q-----------------------------GQPTLVIMELMTRGDLKSHLR----SLRPEA-----------------------------------------------------------------------------------------ENNPGLPQPALGEMIQMAGEIADGMAYLAAN--------KFVHRDLAARNCMVSQ-----DFTV----KIGDFGMTRDV---Y--E--TDYY--------------RKGGKGLLPVRWMAPESLK------DGI---FTTHSDVWSFGVVLWEIVTLAE----------QP---------------YQGL-----------SNEQVLKFV-MDGGV----LEELEGCP------------------------------LQLQELMSRCWQPNPRLRPSFTHILD---SI--------
VGG----NKMGEGGFGVVYKGYVN-------NTT--VAVKKLAAM--V-DITTE---ELKQQFD---QEIKVMAKC-QHENLVELLGFSS--D-----------------------------GDDLCLVYVYMPNGSLLDRLSCLDGTP----------------------------------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHEN--------HHIHRDIKSANILLDE-----AFTA----KISDFGLARASE----KFAQTVMT--------------SR---IVGTTAYMAPEALR-------GE---ITPKSDIYSFGVVLLEIIT-GL----------PA---------------VDEH-----------REPQLLLDI-KEEIE----DEEKTIEDYIDKKMNDAD----------------STSVEAMYSVASQCLHEKKNKRPDIKKVQQ----LLQ------
---LTFVQEIGSGQFGLVHLGYWL--------NKDKVAIKTIR-E--G-AM-SE---E-DFI-E----EAEVMMKL-SHPKLVQLYGVCL--E-----------------------------QAPICLVFEFMEHGCLSDYLR----TQ--------------------------------------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEA--------CVIHRDLAARNCLVGE-----NQVI----KVSDFGMTRFV------L--DDQY--------------TSSTGTKFPVKWASPEVFS------FSR---YSSKSDVWSFGVLMWEVFSEGK----------IP---------------YENR-----------SNSEVVEDI-STGFR----LYKPRLAS------------------------------THVYQIMNHCWKERPEDRPAFSRLLRQL-----------
---LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKLQ-H--S-TE--EH-LR-DFE-R----EIEILKSL-QHDNIVKYKGVCYSAG-----------------------------RRNLKLIMEYLPYGSLRDYLQ----KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTK--------RYIHRDLATRNILVEN-----ENRV----KIGDFGLTKVL--PQ--D--KEYY--------------KVKEPGESPIFWYAPESLT------ESK---FSVASDVWSFGVVLYELFTYIE----------KSKSPPAEFMRMIGNDKQGQM-----------IVFHLIELL-KNNGR----LPRPDGCP------------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV-------
---LSFGKTLGAGAFGKVVEATAYG--LIKSDAAMTVAVKMLK-P--S-AH-LTE-RE-ALM-S----ELKVLSYLGNHMNIVNLLGACT--I-----------------------------GGPTLVITEYCCYGDLLNFLR----RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASK--------NCIHRDLAARNILLTH-----GRIT----KICDFGLARDI---K--N--DSNY--------------VVKGNARLPVKWMAPESIF------NCV---YTFESDVWSYGIFLWELFSLGS----------SP---------------YPGM-P---------VDSKFYKMI-KEGFR----MLSPEHAP------------------------------AEMYDIMKTCWDADPLKRPTFKQIVQL--I---------
---LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-Q--G-SM-SP---D-AFL-A----EANLMKQL-QHQRLVRLYAVVT--------------------------------QEPIYIITEYMENGSLVDFLK----TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEER--------NYIHRDLRAANILVSD-----TLSC----KIADFGLARLI------E--DNEY--------------TAREGAKFPIKWTAPEAIN------YGT---FTIKSDVWSFGILLTEIVTHGR----------IP---------------YPGM-----------TNPEVIQNL-ERGYR----MVRPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L---------
---YQNLSPVGSGAYGSVCAAFDT-------KTGLRVAVKKLSRP--F-QSIIH---A-KRTYR----ELRLLKHM-KHENVIGLLDVFT--PARS-----------------------LEEFNDVYLVTHLMGA-DLNNIVK----CQ----------------------------------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSA--------DIIHRDLKPSNLAVNE-----DCEL----KILDFGLAR---------HTDDEM--------------TG---YVATRWYRAPEIML-----NWMH---YNQTVDIWSVGCIMAELLT-GR----------TL---------------FPGT-----------DHIDQLKLI-LRLVG----TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF---------
-IV--LKWELGEGAFGKVFLAECHN--LLPEQDKMLVAVKALK-E--A-SE-SA--RQ-DFQ-R----EAELLTML-QHQHIVRFFGVCT--E-----------------------------GRPLLMVFEYMRHGDLNRFLR----SHGPDAKL------------------------------------------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGL--------HFVHRDLATRNCLVGQ-----GLVV----KIGDFGMSRDI---Y--S--TDYY--------------RVGGRTMLPIRWMPPESIL------YRK---FTTESDVWSFGVVLWEIFTYGK----------QP---------------WYQL-----------SNTEAIDCI-TQGRE----LERPRACP------------------------------PEVYAIMRGCWQREPQQRHSIKDVHARL-----------
--I-VLKRELGEGAFGKVFLAECYN--LCPEQDKILVAVKTLK-D--A-SD-NA--RK-DFH-R----EAELLTNL-QHEHIVKFYGVCV--E-----------------------------GDPLIMVFEYMKHGDLNKFLR----AHGPDAV--------------------------------------------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQ--------HFVHRDLATRNCLVGE-----NLLV----KIGDFGMSRDV---Y--S--TDYY--------------RVGGHTMLPIRWMPPESIM------YRK---FTTESDVWSLGVVLWEIFTYGK----------QP---------------WYQL-----------SNNEVIECI-TQGRV----LQRPRTCP------------------------------QEVYELMLGCWQREPHMRKNIKGIHTL--L---------
---YELQETLGKGTYGKVKRATER-------FSGRVVAIKSIRKD--K-IKDEQ---D-MVHIR---REIEIMSSL-NHPHIISIYEVFE--N-----------------------------KDKIVIIMEYASKGELYDYIS---ERR----------------------------------------------------------------------------------------------------RLSERETRHFFRQIVSAVHYCHKN--------GVVHRDLKLENILLDD-----NCNI----KIADFGLSNL-------YQKDKFL--------------QT---FCGSPLYASPEIVN-----GRPY---RGPEVDSWALGVLLYTLVY-GT----------MP---------------FDGF--------------DHKNLI-RQISS----GEYREPTQP-----------------------------SDARGLIRWMLMVNPDRRATIEDIANHWW-V--------
--L-VLGRTLGSGAFGQVVEATAHG--LSHSQATMKVAVKMLK-S--T-AR-SSE-KQ-ALM-S----ELKIMSHLGPHLNVVNLLGACT--K-----------------------------GGPIYIITEYCRYGDLVDYLH----RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASK--------NCVHRDLAARNVLICE-----GKLV----KICDFGLARDI---M--R--DSNY--------------ISKGSTFLPLKWMAPESIF------NSL---YTTLSDVWSFGILLWEIFTLGG----------TP---------------YPEL-P---------MNEQFYNAI-KRGYR----MAQPAHAS------------------------------DEIYEIMQKCWEEKFEIRPPFSQLVL---LL--------
-VM--LSTRIGSGSFGTVYKGKWH----------GDVAVKILK-V-VD-PT-PEQ-FQ-AFR-N----EVAVLRKT-RHVNILLFMGYMT--------------------------------KDNLAIVTQWCEGSSLYKHLH----VQ--------------------------------------------------------------------------------------------------ETKFQMFQLIDIARQTAQGMDYLHAK--------NIIHRDMKSNNIFLHE-----GLTV----KIGDFGLATVK---S--R--WSGS--------------QQVEQPTGSVLWMAPEVIR------MQDNNPFSFQSDVYSYGIVLYELMT-GE----------LP---------------YSHI-N---------NRDQIIFMV-GRGYASPDLSKLYKNCP------------------------------KAMKRLVADCVKKVKEERPLFPQILSS--I---------
--L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-E--N-AS-PSE-LR-DLL-S----EFNVLKQV-NHPHVIKLYGACS--Q-----------------------------DGPLLLIVEYAKYGSLRGFLR----ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM--------KLVHRDLAARNILVAE-----GRKM----KISDFGLSRDV---Y--E--EDSY--------------VKRSQGRIPVKWMAIESLF------DHI---YTTQSDVWSFGVLLWEIVTLGG----------NP---------------YPGI-----------PPERLFNLL-KTGHR----MERPDNCS------------------------------EEMYRLMLQCWKQEPDKRPVFADISKDL-----------
-LT--LRLLLGSGAFGEVYEGTAVDI-LGVGSGEIKVAVKTLK-K--G-ST-DQE-KI-EFL-K----EAHLMSKF-NHPNILKQLGVCL--L-----------------------------NEPQYIILELMEGGDLLTYLR----KARM--------------------------------------------------------------------------------------------ATFYGPLLTLVDLVDLCVDISKGCVYLERM--------HFIHRDLAARNCLVSVKDYTSPRIV----KIGDFGLARDI---Y--K--NDYY--------------RKRGEGLLPVRWMAPESLM------DGI---FTTQSDVWSFGILIWEILTLGH----------QP---------------YPAH-----------SNLDVLNYV-QTGGR----LEPPRNCP------------------------------DDLWNLMTQCWAQEPDQRPTFHRIQDQL-----------
--L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-P--G-TM-SP---E-AFL-Q----EAQVMKKL-RHEKLVQLYAVVS--------------------------------EEPIYIVTEYMSKGSLLDFLK----GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERM--------NYVHRDLRAANILVGE-----NLVC----KVADFGLARLI------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILLTELTTKGR----------VP---------------YPGM-----------VNREVLDQV-ERGYR----MPCPPECP------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L---------
TLE---DKELGSGNFGTVKKGYYQ-----MKKVVKTVAVKILK-N--E-AN-DPALKD-ELL-A----EANVMQQL-DNPYIVRMIGICE--------------------------------AESWMLVMEMAELGPLNKYLQ----QN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEES--------NFVHRDLAARNVLLVT-----QHYA----KISDFGLSKAL---R--A--DENY-------------YKAQTHGKWPVKWYAPECIN------YYK---FSSKSDVWSFGVLMWEAFSYGQ----------KP---------------YRGM-----------KGSEVTAML-EKGER----MGCPAGCP------------------------------REMYDLMNLCWTYDVENRPGFAAVE----LRL-------
-IV--LQESIGKGRFGEVWRGKWR-------GEE--VAVKIFSSR--E-ERSWF---R-EA-------EIYQTVML-RHENILGFIAADN--KDN-------------------------GTWTQLWLVSDYHEHGSLFDYLN----RY----------------------------------------------------------------------------------------------------TVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKK-----NGTC----CIADLGLAVRHDS--ATDTIDIAP--------------NH---RVGTKRYMAPEVLDDSINMKHFE---SFKRADIYAMGLVFWEIAR-RCSIGGIHEDYQLP---------------YYDLVP------SDPSVEEMRKVV-CEQKL----RPNIPNRWQSCEAL------------------------RVMAKIMRECWYANGAARLTALRIKK----TL-------
--L-RLLEKLGDGSFGVVRRGEWD----APSGKTVSVAVKCLK-PDVL-SQ-PEA-MD-DFI-R----EVNAMHSL-DHRNLIRLYGVVL--------------------------------TPPMKMVTELAPLGSLLDRLR----KH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESK--------RFIHRDLAARNLLLAT-----RDLV----KIGDFGLMRAL--PQ--N--DDHY--------------VMQEHRKVPFAWCAPESLK------TRT---FSHASDTWMFGVTLWEMFTYGQ----------EP---------------WIGL-----------NGSQILHKIDKEGER----LPRPEDCP------------------------------QDIYNVMVQCWAHKPEDRPTFVALRDF--L---------
--L-AFIKEIGSGQFGVVHLGEWR--------SHIQVAIKAIN-E--G-SM-SE---E-DFI-E----EAKVMMKL-SHSKLVQLYGVCI--Q-----------------------------RKPLYIVTEFMENGCLLNYLR----EN--------------------------------------------------------------------------------------------------KGKLRKEMLLSVCQDICEGMEYLERN--------GYIHRDLAARNCLVSS-----TCIV----KISDFGMTRYV------L--DDEY--------------VSSFGAKFPIKWSPPEVFL------FNK---YSSKSDVWSFGVLMWEVFTEGK----------MP---------------FENK-----------SNLQVVEAI-SEGFR----LYRPHLAP------------------------------MSIYEVMYSCWHEKPEGRPTFAELLR---AV--------
--L-RLEVKLGQGCFGEVWMGTWN--------GTTKVAIKTLK-P--G-TM-MP---E-AFL-Q----EAQIMKKL-RHDKLVPLYAVVS--------------------------------EEPIYIVTEFMSKGSLLDFLK----EG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERM--------NYIHRDLRAANILVGE-----NLVC----KIADFGLARLI------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILQTELVTKGR----------VP---------------YPGM-----------VNREVLEQV-ERGYR----MPCPQGCP------------------------------ESLHELMNLCWKKDPDERPTFEYIQSFL-----------
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