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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK NTRK3 203
Other AURKA 133
Other AURKB 77
Other AURKC 43
CAMK CHEK1 9
CAMK CHEK2 220
Other EIF2AK2 267
TK JAK1 875
TKL LIMK1 339
TK NTRK1 510
TK NTRK2 538
CAMK NUAK1 55
AGC RPS6KA2 59
AGC RPS6KA6 73
AGC RPS6KB1 91
-I-VLKRELGEGAFGKVFLAEC---YNLSPTKDKM---LVAVKALK-DP-TL-AA-RKDFQ-R------EAELLTNLQHEHIVKFYGVCG-D-----------------------------GDP--LIMVFEYMKHGDLNKFLR---AHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLV---KIGDFGMSRDV--Y-S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM---YRKFTTESDVWSFGVILWEIFTYGK-QP--------------WFQL-SNTEVIECITQGRVLERPRVCP------KEVYDVMLGCWQREPQQRLN-----IKEIYKIL-----
--FEIGRPLGKGKFGNVYLARE---K-----QSKF---ILALKVLFKAQLEKAGV--EHQLRR------EVEIQSHLRHPNILRLYGYFH-D-----------------------------ATR--VYLILEYAPLGTVYRELQ--KLS-----------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGEL---KIADFGWSV------HAPSSRR--------------TT---LCGTLDYLPPEMIE---GRMHDEKVDLWSLGVLCYEFLV-GK-PP--------------FEAN----TYQETYKRISRVEFTFPDFVT----EGARDLISRLLKHNPSQRPM-----LREVLEHPWI---
--FEIGRPLGKGKFGNVYLARE---K-----KSHF---IVALKVLFKSQ-IEKEG--VEHQLR-----REIEIQAHLHHPNILRLYNYFY-D-----------------------------RRR--IYLILEYAPRGELYKELQ--KSC-----------------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGEL---KIADFGWSV------HAPSLRR--------------KT---MCGTLDYLPPEMIE---GRMHNEKVDLWCIGVLCYELLV-GN-PP--------------FESA----SHNETYRRIVKVDLKFPASVP----MGAQDLISKLLRHNPSERLP-----LAQVSAHPWV---
--FEIGRPLGKGKFGNVYLARL---K-----ESHF---IVALKVLFKSQ-IEKEG--LEHQLR-----REIEIQAHLQHPNILRLYNYFH-D-----------------------------ARR--VYLILEYAPRGELYKELQ--KSE-----------------KLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV---KIADFGWSV------HTPSLRR--------------KT---MCGTLDYLPPEMIE---GRTYDEKVDLWCIGVLCYELLV-GY-PP--------------FESA----SHSETYRRILKVDVRFPLSMP----LGARDLISRLLRYQPLERLP-----LAQILKHPWV---
-W-DLVQTLGEGAYGEVQLAVN---R-----VTEE---AVAVKIVDMKR-AVDCP--ENI-KK------EICINKMLNHENVVKFYGHRR-E-----------------------------GNI--QYLFLEYCSGGELFDRIE--PDI-----------------GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNL---KISDFGLATVFR--YNNRERLL--------------NK---MCGTLPYVAPELLK--RREFHAEPVDVWSCGIVLTAMLA-GE-LP--------------WDQP---SDSCQEYSDWKEKKTYLNPWKKI--DSAPLALLHKILVENPSARIT-----IPDIKKDRW-Y--
YI--MSKTLGSGACGEVKLAFE---R-----KTCK---KVAIKIISKRK-FAIGS--AREADPALNVETEIEILKKLNHPCIIKIKNFF--D-----------------------------AED--YYIVLELMEGGELFDKVV--GNK-----------------RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKI-----LGETSLM--------------RT---LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GY-PP--------------FSEH---RTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFT-----TEEALRHPWL---
-F-KEIELIGSGGFGQVFKAKH---R-----IDGK---TYVIKRVKYNN-EKAER--------------EVKALAKLDHVNIVHYNGCWD-GFDYDPETSDDSLESSDYDPENSKNSSRSKTKC--LFIQMEFCDKGTLEQWIEKRRGE-----------------KLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQV---KIGDFGLVTS-----LKNDGKR--------------TR---SKGTLRYMSPEQIS---SQDYGKEVDLYALGLILAELLH-VCDTA--------------FET--------SKFFTDLRDGIISDIFDK-----KEKTLLQKLLSKKPEDRPN-----TSEILR----TLT
-L-KRIRDLGEGHFGKVELCRY---DP-EGDNTGE---QVAVKSLK-PE-SG-GNHIADLK-K------EIEILRNLYHENIVKYKGICTED------------------------------GGNGIKLIMEFLPSGSLKEYLP---KN---------------KNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQV---KIGDFGLTKAI-ET-D--KEYY--------------TVKDDRDSPVFWYAPECLM---QSKFYIASDVWSFGVTLHELLTYCD-SDSSPMALFLKMIGPTHGQM-TVTRLVNTLKEGKRLPCPPNCP------DEVYQLMRKCWEFQPSNRTS-----FQNLIE---GF--
LI--HGEVLGKGCFGQAIKVTH---R-----ETGE---VMVMKELI--R-FD-EETQRTFL-K------EVKVMRCLEHPNVLKFIGVLY-K-----------------------------DKR--LNFITEYIKGGTLRGIIK---SM---------------DSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNV---VVADFGLARLM--V-D--EKTQPEGLRS--LKKPDRKKRYTVVGNPYWMAPEMIN---GRSYDEKVDVFSFGIVLCEIIGRVN-AD--------------PDYLPRTMDFGLNVRGFLDRYCPPNCP------PSFFPITVRCCDLDPEKRPS-----FVKLEH---WL--
IV--LKWELGEGAFGKVFLAEC---HNLLPEQDKM---LVAVKALK-EA-SE-SA-RQDFQ-R------EAELLTMLQHQHIVRFFGVCT-E-----------------------------GRP--LLMVFEYMRHGDLNRFLR---SHGPDAKL-LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVV---KIGDFGMSRDI--Y-S--TDYY--------------RVGGRTMLPIRWMPPESIL---YRKFTTESDVWSFGVVLWEIFTYGK-QP--------------WYQL-SNTEAIDCITQGRELERPRACP------PEVYAIMRGCWQREPQQRHS-----IKDVHARL-----
-I-VLKRELGEGAFGKVFLAEC---YNLCPEQDKI---LVAVKTLK-DA-SD-NA-RKDFH-R------EAELLTNLQHEHIVKFYGVCV-E-----------------------------GDP--LIMVFEYMKHGDLNKFLR---AHGPDAV---LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLV---KIGDFGMSRDV--Y-S--TDYY--------------RVGGHTMLPIRWMPPESIM---YRKFTTESDVWSLGVVLWEIFTYGK-QP--------------WYQL-SNNEVIECITQGRVLQRPRTCP------QEVYELMLGCWQREPHMRKN-----IKGIHTL--L---
--YELQETLGKGTYGKVKRATE---R-----FSGR---VVAIKSIRKDK-IKDEQ--DMVHIR-----REIEIMSSLNHPHIISIYEVFE-N-----------------------------KDK--IVIIMEYASKGELYDYIS--ERR-----------------RLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNI---KIADFGLSNL-----YQKDKFL--------------QT---FCGSPLYASPEIVN--GRPYRGPEVDSWALGVLLYTLVY-GT-MP--------------FDGF----DHKNLIRQISSGEYREPTQP-----SDARGLIRWMLMVNPDRRAT-----IEDIANHWW-V--
--FELLKVLGQGSYGKVFLVRK---V-----KGSDAGQLYAMKVLKKAT-LKVRD--RVRSKM------ERDILAEVNHPFIVKLHYAFQ-T-----------------------------EGK--LYLILDFLRGGDLFTRLS--KEV-----------------MFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHI---KITDFGLSKEA----IDHDKRA--------------YS---FCGTIEYMAPEVVN---RRGHTQSADWWSFGVLMFEMLT-GS-LP--------------FQGK----DRKETMALILKAKLGMPQFLS----GEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF---
--FELLKVLGQGSFGKVFLVRK---K-----TGPDAGQLYAMKVLKKAS-LKVRD--RVRTKM------ERDILVEVNHPFIVKLHYAFQ-T-----------------------------EGK--LYLILDFLRGGDVFTRLS--KEV-----------------LFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHI---KLTDFGLSKES----VDQEKKA--------------YS---FCGTVEYMAPEVVN---RRGHSQSADWWSYGVLMFEMLT-GT-LP--------------FQGK----DRNETMNMILKAKLGMPQFLS----AEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFF---
--FELLRVLGKGGYGKVFQVRKVTGA-----NTGK---IFAMKVLKKAM-IVRNA--KDTAHTK----AERNILEEVKHPFIVDLIYAFQ-T-----------------------------GGK--LYLILEYLSGGELFMQLE--REG-----------------IFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHV---KLTDFGLCKES----IHDGTVT--------------HT---FCGTIEYMAPEILM---RSGHNRAVDWWSLGALMYDMLT-GA-PP--------------FTGE----NRKKTIDKILKCKLNLPPYLT----QEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFF---
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