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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
STE PAK4 203
TK BTK 402
CMGC CDK9 2.7.11.23
CAMK CHEK1 9
CMGC GSK3B 56
TK LCK 245
STE PAK7 449
CAMK PRKD3 576
STE SLK 34
DNFI-----KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRREL--LFNEVVIMRDYQHENVVEMYNSYLV--------GDELW--VVMEFLEGG--ALTDIVT-----HT---RMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLT-HDGRV---KLSDFGFCAQV----SKEVPRRKS---LVGTPYWMAPELIS-----RLPYGPEVDIWSLGIMVIEMVD-GEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVS-----------------------------PSLKGFLDRLLVRDPAQRATAAELLKHPFL-
----LTFLKELGTGQFGVVKYGKWR-GQYDVAIKMIK-EGSM-SEDEFI-EEAKVMMNLSHEKLVQLYGVCTK--------QRPIF--IITEYMANG--CLLNYLR-----EM-RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVN-DQGVV---KVSDFGLSRYV----L--DDEYTSSVGSKFPVRWSPPEVLM-----YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLAS-------------------------------EKVYTIMYSCWHEKADERPTFKILLSN--I-
----YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIY--LVFDFCEH---DLAGLLS---NVLV---KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVL---KLADFGLARAFSLAKNSQPNRYTN---RVVTLWYRPPELLL----GERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF-
---W-DLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENI-KKEICINKMLNHENVVKFYGHRRE--------GNIQY--LFLEYCSGG--ELFDRIE----PDI---GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL---KISDFGLATVFR--YNNRERLLNK---MCGTLPYVAPELLK----RREFHAEPVDVWSCGIVLTAMLA-GELPWDQP--SDSCQEYSDWKEKKTYLNPWKKI--D-------------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y
----YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR------ELQIMRKLDHCNIVRLRYFFYSSG----EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ---TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ-----LVRGEPNVS---YICSRYYRAPELIF----GATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH---PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF-
----LKLVERLGAGQFGEVWMGYYN-GHTKVAVKSLK-QGSM-SPDAFL-AEANLMKQLQHQRLVRLYAVVT---------QEPIY--IITEYMENG--SLVDFLK-----TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSC---KIADFGLARLI----E--DNEYTAREGAKFPIKWTAPEAIN-----YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP-------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L-
ANFI-----KIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRREL--LFNEVVIMRDYHHDNVVDMYSSYLV--------GDELW--VVMEFLEGG--ALTDIVT-----HT---RMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLT-SDGRI---KLSDFGFCAQV----SKEVPKRKS---LVGTPYWMAPEVIS-----RLPYGTEVDIWSLGIMVIEMID-GEPPYFNEPPLQAMRRIRDSLPPRVKDLHK----VS-------------------------SVLRGFLDLMLVREPSQRATAQELLGHPFL-
-FAD----EVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFET--------PERVF--VVMEKLHGD--MLEMILS---SEKS---RLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLA-SAEPFPQVKLCDFGFARI-----IGEKSFRRS---VVGTPAYLAPEVLR-----SKGYNRSLDMWSVGVIIYVSLS-GTFPFNED-----EDINDQIQNAAFMYPPNPWREIS-------------------------GEAIDLINNLLQVKMRKRYSVDKSLSHPWL-
----WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYM--VEIDILASCDHPNIVKLLDAFYY--------ENNLW--ILIEFCAGG--AVDAVML---ELER---PLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFT-LDGDI---KLADFGVSAKN----TRTIQRRDS---FIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAE-IEPPHHELNPMRVLLKIAKSEPPTLAQPSRWS-----------------------------SNFKDFLKKCLEKNVDARWTTSQLLQHPFV-
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