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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC PDPK1 203
TK ABL1 261
TK ABL2 288
AGC AKT1 150
Other AURKA 133
Other AURKB 77
Other AURKC 43
TKL BRAF 456
TK BTK 402
CMGC CDC2 4
CMGC CDC2L6 20
CMGC CDK2 4
CMGC CDK4 6
CMGC CDK5 4
CAMK CHEK1 9
CMGC CSNK2A1 39
TK EGFR 712
Other GAK 40
CMGC GSK3A 119
CMGC GSK3B 56
CMGC HIPK4 -1
TK JAK2 849
TK JAK3 822
TKL LIMK2 331
TK LYN 247
CMGC MAPK1 13
CMGC MAPK10 64
CMGC MAPK14 24
CMGC MAPK7 55
CMGC MAPK8 26
CMGC MAPK9 26
CAMK MAPKAPK2 64
CAMK MELK 11
Other PLK1 53
Other PLK2 82
Other PLK3 62
Other PLK4 12
AGC PRKCB 342
AGC PRKCD 349
AGC PRKCH 355
AGC PRKCQ 380
TK RET 724
CAMK STK17A 61
CAMK STK33 116
Other TTK 525
--F-KFGKILGEGSFSTVVLAREL-----ATSR--EYAI-KILEKR-H-IIK---EN--KVPYVTR-ERDVMSRL-D-----HPFFVKLYFTFQ--D--------DEKLY--FGLSYAKNG--ELLKYIR-------KIG-------------------------SF---DETCTRFYTAEIVSALEYLHG-K--GIIHRDLKPENILLN----EDMHI---------QITDFGTAKVLS------------------PESKQARA---------NS---FVGTAQYVSPELLT-----------EKS---ACKSSDLWALGCIIYQLVA-GLPP---------------FR-AG------------NEYLIFQKIIK----LEYDFPEKFF---------------------------------------------------------------------------PKARDLVEKLLVLDATKRLG------CE-EM------EGYGPLKAHPF---
---ITMKHKLGGGQYGEVYEGVWK-----KYSL--TVAV-KTLK-E-D-TM----EV--EE-FL-K-EAAVMKEI-K-----HPNLVQLLGVCT--R--------EPPFY--IITEFMTYG--NLLDYLR--------EC----------------------NRQEV---NAVVLLYMATQISSAMEYLEK-K--NFIHRDLAARNCLVG----ENHLV---------KVADFGLSRLM--------------------T--GDTY---------TAHAGAKFPIKWTAPESLA-----------YNK---FSIKSDVWAFGVLLWEIATYGMSP---------------YP-GI---------DLSQVYELLEKDYR----MERPEGCP-----------------------------------------------------------------------------EKVYELMRACWQWNPSDRPS------FA-EIHQA--F--------------
---ITMKHKLGGGQYGEVYVGVWK-----KYSL--TVAV-KTLK-E-D-TM----EV--EE-FL-K-EAAVMKEI-K-----HPNLVQLLGVCT--L--------EPPFY--IVTEYMPYG--NLLDYLR--------EC----------------------NREEV---TAVVLLYMATQISSAMEYLEK-K--NFIHRDLAARNCLVG----ENHVV---------KVADFGLSRLM--------------------T--GDTY---------TAHAGAKFPIKWTAPESLA-----------YNT---FSIKSDVWAFGVLLWEIATYGMSP---------------YP-GI---------DLSQVYDLLEKGYR----MEQPEGCP-----------------------------------------------------------------------------PKVYELMRACWKWSPADRPS------FA-ETHQA--F--------------
--F-EYLKLLGKGTFGKVILVKEK-----ATGR--YYAM-KILKKE-V-IVA---KD--EV-AHTLTENRVLQNS-R-----HPFLTALKYSFQ--T--------HDRLC--FVMEYANGG--ELFFHLS-------RER-------------------------VF---SEDRARFYGAEIVSALDYLHSEK--NVVYRDLKLENLMLD----KDGHI---------KITDFGLCKEG--------------------IKDGATM---------KT---FCGTPEYLAPEVLE-----------DND---YGRAVDWWGLGVVMYEMMC-GRLP---------------FY-NQ------------DHEKLFELILM----EEIRFPRTLG---------------------------------------------------------------------------PEAKSLLSGLLKKDPKQRLGGG-SEDAK-EIMQHRFF--------------
---FEIGRPLGKGKFGNVYLAREK-----QSKF--ILAL-KVLFKA-QLEKA---GV--EH-QLRR-EVEIQSHL-R-----HPNILRLYGYFH--D--------ATRVY--LILEYAPLG--TVYRELQ-------KLS-------------------------KF---DEQRTATYITELANALSYCHS-K--RVIHRDIKPENLLLG----SAGEL---------KIADFGWSV----------------------HAPSSRR---------TT---LCGTLDYLPPEMIE-----------GRM---HDEKVDLWSLGVLCYEFLV-GKPP---------------FE-AN------------TYQETYKRISR----VEFTFPDFVT---------------------------------------------------------------------------EGARDLISRLLKHNPSQRPM------LR-EVLEHPWI--------------
---FEIGRPLGKGKFGNVYLAREK-----KSHF--IVAL-KVLFKS-Q-IEK---EG--VE-HQLRREIEIQAHL-H-----HPNILRLYNYFY--D--------RRRIY--LILEYAPRG--ELYKELQ-------KSC-------------------------TF---DEQRTATIMEELADALMYCHG-K--KVIHRDIKPENLLLG----LKGEL---------KIADFGWSV----------------------HAPSLRR---------KT---MCGTLDYLPPEMIE-----------GRM---HNEKVDLWCIGVLCYELLV-GNPP---------------FE-SA------------SHNETYRRIVK----VDLKFPASVP---------------------------------------------------------------------------MGAQDLISKLLRHNPSERLP------LA-QVSAHPWV--------------
---FEIGRPLGKGKFGNVYLARLK-----ESHF--IVAL-KVLFKS-Q-IEK---EG--LE-HQLRREIEIQAHL-Q-----HPNILRLYNYFH--D--------ARRVY--LILEYAPRG--ELYKELQ-------KSE-------------------------KL---DEQRTATIIEELADALTYCHD-K--KVIHRDIKPENLLLG----FRGEV---------KIADFGWSV----------------------HTPSLRR---------KT---MCGTLDYLPPEMIE-----------GRT---YDEKVDLWCIGVLCYELLV-GYPP---------------FE-SA------------SHSETYRRILK----VDVRFPLSMP---------------------------------------------------------------------------LGARDLISRLLRYQPLERLP------LA-QILKHPWV--------------
---ITVGQRIGSGSFGTVYKGKWH--------G--DVAV-KMLN-VTA-PT----PQQLQA-FK-N-EVGVLRKT-R-----HVNILLFMGYST-----------KPQLA--IVTQWCEGS--SLYHHLH--------II-----------------------ETKF---EMIKLIDIARQTAQGMDYLHA-K--SIIHRDLKSNNIFLH----EDLTV---------KIGDFGLATVK-------------S------R--WSGS---------HQFEQLSGSILWMAPEVIR-----------MQDKNPYSFQSDVYAFGIVLYELMT-GQLP---------------YS-NI-N-------NRDQIIFMVGRGYLSPDLSKVRSNCP-----------------------------------------------------------------------------KAMKRLMAECLKKKRDERPL------FP-QILA---SI-------------
---LTFLKELGTGQFGVVKYGKWR------GQY--DVAI-KMIK-E-G-SM----SE--DE-FI-E-EAKVMMNL-S-----HEKLVQLYGVCT--K--------QRPIF--IITEYMANG--CLLNYLR--------EM-----------------------RHRF---QTQQLLEMCKDVCEAMEYLES-K--QFLHRDLAARNCLVN----DQGVV---------KVSDFGLSRYV--------------------L--DDEY---------TSSVGSKFPVRWSPPEVLM-----------YSK---FSSKSDIWAFGVLMWEIYSLGKMP---------------YE-RF---------TNSETAEHIAQGLR----LYRPHLAS-----------------------------------------------------------------------------EKVYTIMYSCWHEKADERPT------FK-ILLSN--I--------------
---YTKIEKIGEGTYGVVYKGRHK-----TTGQ--VVAM-KKIRLE-S-EEE---GV--PS-TAIR-EISLLKEL-R-----HPNIVSLQDVLM--Q--------DSRLY--LIFEFLSM---DLKKYLDS----IPPGQ-------------------------YM---DSSLVKSYLYQILQGIVFCHS-R--RVLHRDLKPQNLLID----DKGTI---------KLADFGLARAF--------------------GIPIRVY---------TH---EVVTLWYRSPEVLL----------GSAR---YSTPVDIWSIGTIFAELAT-KKPL---------------FH-GD---------SEIDQLFRIFRALG----TPNNEVWPEVESLQDYKNTFPKWKP-------------------------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS------GK-MALNHPYF--------------
EGC-----KVGRGTYGHVYKARRK-----DGKDEKEYAL-KQIEGT-G-ISM---SA--C-----R-EIALLREL-K-----HPNVIALQKVFL--SH------SDRKVW--LLFDYAEH---DLWHIIKFHRASKANKK-------------------------PMQ-LPRSMVKSLLYQILDGIHYLHA-N--WVLHRDLKPANILVMGEGPERGRV---------KIADMGFARLFN-----------------SPLKPLADL---------DP---VVVTFWYRAPELLL----------GARH---YTKAIDIWAIGCIFAELLT-SEPI---------------FH-CRQEDIKTSNPFHHDQLDRIFSVMG----FPADKDWEDIRKMPEYPTLQKDFRRTTYA----------------------------------------NSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRIT------SE-QALQDPYF--------------
---FQKVEKIGEGTYGVVYKARNK-----LTGE--VVAL-KKIRLD-T-ETE---GV--PS-TAIR-EISLLKEL-N-----HPNIVKLLDVIH--T--------ENKLY--LVFEFLHQ---DLKKFMDA-----SALT-------------------------GI---PLPLIKSYLFQLLQGLAFCHS-H--RVLHRDLKPQNLLIN----TEGAI---------KLADFGLARAF--------------------GVPVRTY---------TH---EVVTLWYRAPEILL----------GCKY---YSTAVDIWSLGCIFAEMVT-RRAL---------------FP-GD---------SEIDQLFRIFRTLG----TPDEVVWPGVTSMPDYKPSFPKWAR-------------------------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS------AK-AALAHPFF--------------
--Y-EPVAEIGVGAYGTVYKARDP-----HSGH--FVAL-KSVRVP-N-GGGGGGGL--PI-STVR-EVALLRRL-EA--FEHPNVVRLMDVCA--TSR---TDREIKVT--LVFEHVDQ---DLRTYLDK-----APPP-------------------------GL---PAETIKDLMRQFLRGLDFLHA-N--CIVHRDLKPENILVT----SGGTV---------KLADFGLARI---------------------YSYQMAL---------TP---VVVTLWYRAPEVLL-----------QST---YATPVDMWSVGCIFAEMFR-RKPL---------------FC-GN---------SEADQLGKIFDLIG----LPPEDDWPRDVSLPRGAFPPRGPR---------------------------------------------------PVQSVVPEMEESGAQLLLEMLTFNPHKRIS------AF-RALQHSYL--------------
---YEKLEKIGEGTYGTVFKAKNR-----ETHE--IVAL-KRVRLD-D-DDE---GV--PS-SALR-EICLLKEL-K-----HKNIVRLHDVLH--S--------DKKLT--LVFEFCDQ---DLKKYFD------SCNG-------------------------DL---DPEIVKSFLFQLLKGLGFCHS-R--NVLHRDLKPQNLLIN----RNGEL---------KLADFGLARAF--------------------GIPVRCY---------SA---EVVTLWYRPPDVLF----------GAKL---YSTSIDMWSAGCIFAELANAGRPL---------------FP-GN---------DVDDQLKRIFRLLG----TPTEEQWPSMTKLPDYKPYPMYPAT-------------------------------------------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS------AE-EALQHPYF--------------
--W-DLVQTLGEGAYGEVQLAVNR-----VTEE--AVAV-KIVDMK-R-AVD---CP--EN-I-KK-EICINKML-N-----HENVVKFYGHRR--E--------GNIQY--LFLEYCSGG--ELFDRIE-------PDI-------------------------GM---PEPDAQRFFHQLMAGVVYLHG-I--GITHRDIKPENLLLD----ERDNL---------KISDFGLATVFR------------------YNNRERLL---------NK---MCGTLPYVAPELLK----------RREF---HAEPVDVWSCGIVLTAMLA-GELP---------------WD-QP-----------SDSCQEYSDWKE----KKTYLNPWKKI--D-----------------------------------------------------------------------SAPLALLHKILVENPSARIT------IP-DIKKDRW-Y-------------
---YQLVRKLGRGKYSEVFEAINI-----TNNE--KVVV-KILKPV-K-KKK---IK--R-------EIKILENLRG-----GPNIITLADIVK--DP------VSRTPA--LVFEHVNNT--DFKQLY----------Q-------------------------TL---TDYDIRFYMYEILKALDYCHS-M--GIMHRDVKPHNVMID---HEHRKL---------RLIDWGLAEF---------------------YHPGQEY---------NV---RVASRYFKGPELLV----------DYQM---YDYSLDMWSLGCMLASMIF-RKEP---------------FFHGH---------DNYDQLVRIAKVLG----TEDLYDYIDKYNIELDPRFNDILGRHSRK-----------------------------------------RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT------AR-EAMEHPYF--------------
--F-KKIKVLGSGAFGTVYKGLWIP-EGEKVKI--PVAI-KELR-E-A-TS----PKANKE-IL-D-EAYVMASV-D-----NPHVCRLLGICL-----------TSTVQ--LITQLMPFG--CLLDYVR--------EH-----------------------KDNI---GSQYLLNWCVQIAKGMNYLED-R--RLVHRDLAARNVLVK----TPQHV---------KITDFGLAKLL-------------G------A--EEKE---------YHAEGGKVPIKWMALESIL-----------HRI---YTHQSDVWSYGVTVWELMTFGSKP---------------YD-GI---------PASEISSILEKGER----LPQPPICT-----------------------------------------------------------------------------IDVYMIMVKCWMIDADSRPK------FR-ELI----IEF------------
-LR--VRRVLAEGGFAFVYEAQDV-----GSGR--EYAL-KRLLSN-E-EEK---NR--AI---IQ-EVCFMKKLSG-----HPNIVQFCSAAS--IGKEESDTGQAEFL--LLTELCKG---QLVEFLKK----MESRG-------------------------PL---SCDTVLKIFYQTCRAVQHMHR-QKPPIIHRDLKVENLLLS----NQGTI---------KLCDFGSATTISHYPDY--------SWSAQRRALVEEE---------IT---RNTTPMYRTPEIIDL--------YSNFP---IGEKQDIWALGCILYLLCF-RQHP---------------FE-DG------------AKLRIVNGKYS-----IPPHDTQY----------------------------------------------------------------------------TVFHSLIRAMLQVNPEERLS------IA-EVVHQ---L-------------
---YTDIKVIGNGSFGVVYQARLA-----ETRE--LVAI-KKVLQD-K-RFK---NR----------ELQIMRKL-D-----HCNIVRLRYFFY--SSG----EKKDELYLNLVLEYVPETVYRVARHFT------KAKL-------------------------TI---PILYVKVYMYQLFRSLAYIHS-Q--GVCHRDIKPQNLLVD---PDTAVL---------KLCDFGSAKQ---------------------LVRGEPN---------VS---YICSRYYRAPELIF----------GATD---YTSSIDVWSAGCVLAELLL-GQPI---------------FP-GD---------SGVDQLVEIIKVLG----TPTREQIREMNPNYTEFKFPQIKAH-------------------------------------------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLS------PL-EACAHSFF--------------
---YTDTKVIGNGSFGVVYQAKLC-----DSGE--LVAI-KKVLQD-K-RFK---NR----------ELQIMRKL-D-----HCNIVRLRYFFY--SSG----EKKDEVYLNLVLDYVPETVYRVA---RHY---SRAKQ-------------------------TL---PVIYVKLYMYQLFRSLAYIHS-F--GICHRDIKPQNLLLD---PDTAVL---------KLCDFGSAKQ---------------------LVRGEPN---------VS---YICSRYYRAPELIF----------GATD---YTSSIDVWSAGCVLAELLL-GQPI---------------FP-GD---------SGVDQLVEIIKVLG----TPTREQIREMNPNYTEFKFPQIKAH-------------------------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT------PL-EACAHSFF--------------
---YDIIEVLGKGTFGEVAKGWRR-----STGE--MVAI-KILKND-A-YRN---RI--IK-N----ELKLLHCM-RGLDPEEAHVIRFLEFFH--D--------ALKFY--LVFELLEQ---NLFEFQK--------EN-------------------------NFAPLPARHIRTVTLQVLTALARLKE-L--AIIHADLKPENIMLV----DQTRCPF-----RVKVIDFGSASIF--------------------SEVRYVK---------EP---YIQSRFYRAPEILL-----------GLP---FCEKVDVWSLGCVMAELHL-GWPL---------------YP-GN---------NEYDQVRYICETQG----LPKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERIS------PS-AALRHPFV--------------
---LKFLQQLGKGNFGSVEMCRYDP-LQDNTGE--VVAV-KKLQ-H-S-TE-----EHLRD-FE-R-EIEILKSL-Q-----HDNIVKYKGVCYSAG--------RRNLK--LIMEYLPYG--SLRDYLQ--------KH-----------------------KERI---DHIKLLQYTSQICKGMEYLGT-K--RYIHRDLATRNILVE----NENRV---------KIGDFGLTKVL------------PQ------D--KEYY---------KVKEPGESPIFWYAPESLT-----------ESK---FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQG-QM---------IVFHLIELLKNNGR----LPRPDGCP-----------------------------------------------------------------------------DEIYMIMTECWNNNVNQRPS------FR-DLA----LRV------------
--L-KYISQLGKGNFGSVELCRYDP-LGDNTGA--LVAV-KQLQ-H-S-GP----DQ-QRD-FQ-R-EIQILKAL-H-----SDFIVKYRGVSYGPG--------RQSLR--LVMEYLPSG--CLRDFLQ--------RH-----------------------RARL---DASRLLLYSSQICKGMEYLGS-R--RCVHRDLAARNILVE----SEAHV---------KIADFGLAKLL------------PL------D--KDYY---------VVREPGQSPIFWYAPESLS-----------DNI---FSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCER-DV-P-------ALCRLLELLEEGQR----LPAPPACP-----------------------------------------------------------------------------AEVHELMKLCWAPSPQDRPS------FS-ALGP---QL-------------
-LI--HGEVLGKGFFGQAIKVTHK------ATG--KVMVMKEL--I-R-CD----EETQKT-FL-T-EVKVMRSL-D-----HPNVLKFIGVLY--K--------DKKLN--LLTEYIEGG--TLKDFLR--------SM------------------------DPF---PWQQKVRFAKGIASGMAYLHS-M--CIIHRDLNSHNCLIK----LDKTV---------VVADFGLSRLIVEERKRAPMEKATT------------KKRTLRKNDRKKRYTVVGNPYWMAPEMLN-----------GKS---YDETVDIFSFGIVLCEIIGQVYAD---------------PD-CL-P-------RTLDFGLNVKLFWE----KFVPTDCP-----------------------------------------------------------------------------PAFFPLAAICCRLEPESRPA------FS-KLED---SF-------------
---IKLVKRLGAGQFGEVWMGYYN------NST--KVAV-KTLK-P-G-TM----SV--QA-FL-E-EANLMKTL-Q-----HDKLVRLYAVVT--R--------EEPIY--IITEYMAKG--SLLDFLK--------SD----------------------EGGKV---LLPKLIDFSAQIAEGMAYIER-K--NYIHRDLRAANVLVS----ESLMC---------KIADFGLARVI--------------------E--DNEY---------TAREGAKFPIKWTAPEAIN-----------FGC---FTIKSDVWSFGILLYEIVTYGKIP---------------YP-GR---------TNADVMTALSQGYR----MPRVENCP-----------------------------------------------------------------------------DELYDIMKMCWKEKAEERPT------FD-YLQSV--L--------------
---YTNLSYIGEGAYGMVCSAYDN-----VNKV--RVAI-KKISPF-E-HQT---YC--QR-T-LR-EIKILLRF-R-----HENIIGINDIIR--APT---IEQMKDVY--IVQDLMET---DLYKLLK--------TQ-------------------------HL---SNDHICYFLYQILRGLKYIHS-A--NVLHRDLKPSNLLLN----TTCDL---------KICDFGLARVAD-----------------PDHDHTGFL---------TE---YVATRWYRAPEIML----------NSKG---YTKSIDIWSVGCILAEMLS-NRPI---------------FP-GK---------HYLDQLNHILGILG----SPSQEDLNCIINLKARNYLLSLPHKN-----------------------------------------------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIE------VE-QALAHPYL--------------
---YQNLKPIGSGAQGIVCAAYDA-----VLDR--NVAI-KKLSRP-F-QNQ---TH--AK-RAYR-ELVLMKCV-N-----HKNIISLLNVFT--PQKT--LEEFQDVY--LVMELMDA---NLCQVIQ---------M-------------------------EL---DHERMSYLLYQMLCGIKHLHS-A--GIIHRDLKPSNIVVK----SDCTL---------KILDFGLART---------------------AGTSFMM---------TP---YVVTRYYRAPEVIL-----------GMG---YKENVDIWSVGCIMGEMVR-HKIL---------------FP-GR---------DYIDQWNKVIEQLG----TPCPEFMKKLQPTVRNYVENRPKYAGLTFPK------------------------------------LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS------VD-DALQHPYI--------------
---YQNLSPVGSGAYGSVCAAFDT-----KTGL--RVAV-KKLSRP-F-QSI---IH--AK-RTYR-ELRLLKHM-K-----HENVIGLLDVFT--PARS--LEEFNDVY--LVTHLMGA---DLNNIVK--------CQ-------------------------KL---TDDHVQFLIYQILRGLKYIHS-A--DIIHRDLKPSNLAVN----EDCEL---------KILDFGLAR-----------------------HTDDEM---------TG---YVATRWYRAPEIML----------NWMH---YNQTVDIWSVGCIMAELLT-GRTL---------------FP-GT---------DHIDQLKLILRLVG----TPGAELLKKISSESARNYIQSLTQMP-----------------------------------------------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT------AA-QALAHAYF--------------
---YEIIETIGNGAYGVVSSARRR-----LTGQ--QVAI-KKIPNA-F-DVV---TN--AK-RTLR-ELKILKHF-K-----HDNIIAIKDILR--PTVP--YGEFKSVY--VVLDLMES---DLHQIIH-------SSQ-------------------------PL---TLEHVRYFLYQLLRGLKYMHS-A--QVIHRDLKPSNLLVN----ENCEL---------KIGDFGMARGLCT----------------SPAEHQYFM---------TE---YVATRWYRAPELML----------SLHE---YTQAIDLWSVGCIFGEMLA-RRQL---------------FP-GK---------NYVHQLQLIMMVLG----TPSPAVIQAVGAERVRAYIQSLPPRQ-----------------------------------------------PVPWETVYPGADRQALSLLGRMLRFEPSARIS------AA-AALRHPFL--------------
---YQNLKPIGSGAQGIVCAAYDA-----ILER--NVAI-KKLSRP-F-QNQ---TH--AK-RAYR-ELVLMKCV-N-----HKNIIGLLNVFT--PQKS--LEEFQDVY--IVMELMDA---NLCQVIQ---------M-------------------------EL---DHERMSYLLYQMLCGIKHLHS-A--GIIHRDLKPSNIVVK----SDCTL---------KILDFGLART---------------------AGTSFMM---------TP---YVVTRYYRAPEVIL-----------GMG---YKENVDLWSVGCIMGEMVC-HKIL---------------FP-GR---------DYIDQWNKVIEQLG----TPCPEFMKKLQPTVRTYVENRPKYAGYSFEK------------------------------------LFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS------VD-EALQHPYI--------------
---YQQLKPIGSGAQGIVCAAFDT-----VLGI--NVAV-KKLSRP-F-QNQ---TH--AK-RAYR-ELVLLKCV-N-----HKNIISLLNVFT--PQKT--LEEFQDVY--LVMELMDA---NLCQVIH---------M-------------------------EL---DHERMSYLLYQMLCGIKHLHS-A--GIIHRDLKPSNIVVK----SDCTL---------KILDFGLART---------------------ACTNFMM---------TP---YVVTRYYRAPEVIL-----------GMG---YKENVDIWSVGCIMGELVK-GCVI---------------FQ-GT---------DHIDQWNKVIEQLG----TPSAEFMKKLQPTVRNYVENRPKYPGIKFEE------------------------------------LFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRIS------VD-EALRHPYI--------------
KVT---SQVLGLGINGKVLQIFNK-----RTQE--KFAL-KMLQDC-P-KAR-------------R-EVELHWRASQ-----CPHIVRIVDVYE--NLY----AGRKCLL--IVMECLDGG--ELFSRIQD-----RGDQ-------------------------AF---TEREASEIMKSIGEAIQYLHS-I--NIAHRDVKPENLLYT----SKRPNA------ILKLTDFGFAKE---------------------TTSHNSL---------TT---PCYTPYYVAPEVLG-----------PEK---YDKSCDMWSLGVIMYILLC-GYPP---------------FY-SN--------HGLAISPGMKTRIRM----GQYEFPNPEWSEVS-----------------------------------------------------------------------EEVKMLIRNLLKTEPTQRMT------IT-EFMNHPWI--------------
---YELHETIGTGGFAKVKLACHI-----LTGE--MVAI-KIMDKN-T-LGS---DL--PR-IKT--EIEALKNL-R-----HQHICQLYHVLE--T--------ANKIF--MVLEYCPGG--ELFDYII-------SQD-------------------------RL---SEEETRVVFRQIVSAVAYVHS-Q--GYAHRDLKPENLLFD----EYHKL---------KLIDFGLCAKP-------------------KGNKDYHL---------QT---CCGSLAYAAPELIQ----------GKSY---LGSEADVWSMGILLYVLMC-GFLP---------------FD-DD------------NVMALYKKIMR----GKYDVPKWLS---------------------------------------------------------------------------PSSILLLQQMLQVDPKKRIS------MK-NLLNHPWI--------------
-YV--RGRFLGKGGFAKCFEISDA-----DTKE--VFAG-KIVPKS-L-LLK---PH--QR-EKMSMEISIHRSL-A-----HQHVVGFHGFFE--D--------NDFVF--VVLELCRRR--SLLELHK-------RRK-------------------------AL---TEPEARYYLRQIVLGCQYLHR-N--RVIHRDLKLGNLFLN----EDLEV---------KIGDFGLATKV--------------------EYDGERK---------KT---LCGTPNYIAPEVLS-----------KKG---HSFEVDVWSIGCIMYTLLV-GKPP---------------FE-TS------------CLKETYLRIKK----NEYSIPKHIN---------------------------------------------------------------------------PVAASLIQKMLQTDPTARPT------IN-ELLNDEFF--------------
--Y-CRGKVLGKGGFAKCYEMTDL-----TNNK--VYAA-KIIPHS-R-VAK---PH--QR-EKIDKEIELHRIL-H-----HKHVVQFYHYFE--D--------KENIY--ILLEYCSRR--SMAHILK-------ARK-------------------------VL---TEPEVRYYLRQIVSGLKYLHE-Q--EILHRDLKLGNFFIN----EAMEL---------KVGDFGLAARL--------------------EPLEHRR---------RT---ICGTPNYLSPEVLN-----------KQG---HGCESDIWALGCVMYTMLL-GRPP---------------FE-TT------------NLKETYRCIRE----ARYTMPSSLL---------------------------------------------------------------------------APAKHLIASMLSKNPEDRPS------LD-DIIRHDFF--------------
-YL--KGRLLGKGGFARCYEATDT-----ETGS--AYAV-KVIPQS-R-VAK---PH--QR-EKILNEIELHRDL-Q-----HRHIVRFSHHFE--D--------ADNIY--IFLELCSRK--SLAHIWK-------ARH-------------------------TL---LEPEVRYYLRQILSGLKYLHQ-R--GILHRDLKLGNFFIT----ENMEL---------KVGDFGLAARL--------------------EPPEQRK---------KT---ICGTPNYVAPEVLL-----------RQG---HGPEADVWSLGCVMYTLLC-GSPP---------------FE-TA------------DLKETYRCIKQ----VHYTLPASLS---------------------------------------------------------------------------LPARQLLAAILRASPRDRPS------ID-QILRHDFF--------------
--F-KVGNLLGKGSFAGVYRAESI-----HTGL--EVAI-KMIDKK-A-MYK---AG--MV-QRVQNEVKIHCQL-K-----HPSILELYNYFE--D--------SNYVY--LVLEMCHNG--EMNRYLK------NRVK-------------------------PF---SENEARHFMHQIITGMLYLHS-H--GILHRDLTLSNLLLT----RNMNI---------KIADFGLATQL--------------------KMPHEKH---------YT---LCGTPNYISPEIAT-----------RSA---HGLESDVWSLGCMFYTLLI-GRPP---------------FD-TD------------TVKNTLNKVVL----ADYEMPSFLS---------------------------------------------------------------------------IEAKDLIHQLLRRNPADRLS------LS-SVLDHPFM--------------
--F-NFLMVLGKGSFGKVMLSERK-----GTDE--LYAV-KILKKD-V-VIQ---DD--DV-ECTMVEKRVLALPGK-----PPFLTQLHSCFQ--T--------MDRLY--FVMEYVNGG--DLMYHIQ-------QVG-------------------------RF---KEPHAVFYAAEIAIGLFFLQS-K--GIIYRDLKLDNVMLD----SEGHI---------KIADFGMCKEN--------------------IWDGVTT---------KT---FCGTPDYIAPEIIA-----------YQP---YGKSVDWWAFGVLLYEMLA-GQAP---------------FE-GE------------DEDELFQSIME----HNVAYPKSMS---------------------------------------------------------------------------KEAVAICKGLMTKHPGKRLG------C----------GPEGERDIKEHAFF
-FI--FHKVLGKGSFGKVLLGELK-----GRGE--YFAI-KALKKD-V-VLI---DD--DV-ECTMVEKRVLTLAAE-----NPFLTHLICTFQ--T--------KDHLF--FVMEFLNGG--DLMYHIQ-------DKG-------------------------RF---ELYRATFYAAEIMCGLQFLHS-K--GIIYRDLKLDNVLLD----RDGHI---------KIADFGMCKEN--------------------IFGESRA---------ST---FCGTPDYIAPEILQ-----------GLK---YTFSVDWWSFGVLLYEMLI-GQSP---------------FH-GD------------DEDELFESIRV----DTPHYPRWIT---------------------------------------------------------------------------KESKDILEKLFEREPTKRLG-----VTG-NIKIHPFF--------------
---FEFIRVLGKGSFGKVMLARVK-----ETGD--LYAV-KVLKKD-V-ILQ---DD--DV-ECTMTEKRILSLARN-----HPFLTQLFCCFQ--T--------PDRLF--FVMEFVNGG--DLMFHIQ-------KSR-------------------------RF---DEARARFYAAEIISALMFLHD-K--GIIYRDLKLDNVLLD----HEGHC---------KLADFGMCKEG--------------------ICNGVTT---------AT---FCGTPDYIAPEILQ-----------EML---YGPAVDWWAMGVLLYEMLC-GHAP---------------FE-AE------------NEDDLFEAILN----DEVVYPTWLH---------------------------------------------------------------------------EDATGILKSFMTKNPTMRLGSLTQGGEH-AILRHPF-F-------------
-FI--LHKMLGKGSFGKVFLAEFK-----KTNQ--FFAI-KALKKD-V-VLM---DD--DV-ECTMVEKRVLSLAWE-----HPFLTHMFCTFQ--T--------KENLF--FVMEYLNGG--DLMYHIQ-------SCH-------------------------KF---DLSRATFYAAEIILGLQFLHS-K--GIVYRDLKLDNILLD----KDGHI---------KIADFGMCKEN--------------------MLGDAKT---------NT---FCGTPDYIAPEILL-----------GQK---YNHSVDWWSFGVLLYEMLI-GQSP---------------FH-GQ------------DEEELFHSIRM----DNPFYPRWLE---------------------------------------------------------------------------KEAKDLLVKLFVREPEKRLG------VRGDIRQHPLF--------------
--L-VLGKTLGEGEFGKVVKATAFHLKGRAGYT--TVAV-KMLK-E-N-AS----PSELRD-LL-S-EFNVLKQV-N-----HPHVIKLYGACS--Q--------DGPLL--LIVEYAKYG--SLRGFLR--------ESRKVGPGYLGSGGSRNSSSLDHPDERAL---TMGDLISFAWQISQGMQYLAE-M--KLVHRDLAARNILVA----EGRKM---------KISDFGLSRDV-------------Y------E--EDSY---------VKRSQGRIPVKWMAIESLF-----------DHI---YTTQSDVWSFGVLLWEIVTLGGNP---------------YP-GI---------PPERLFNLLKTGHR----MERPDNCS-----------------------------------------------------------------------------EEMYRLMLQCWKQEPDKRPV------FA-DISKDL----------------
LCP---GRELGRGKFAVVRKCIKK-----DSGK--EFAA-KFMRKR-R-KGQ---DC--RM-EIIH-EIAVLELAQD-----NPWVINLHEVYE--T--------ASEMI--LVLEYAAGG--EIFDQCVA-----DREE-------------------------AF---KEKDVQRLMRQILEGVHFLHT-R--DVVHLDLKPQNILLT----SESPLG------DIKIVDFGLSRI---------------------LKNSEEL---------RE---IMGTPEYVAPEILS-----------YDP---ISMATDMWSIGVLTYVMLT-GISP---------------FL-GN------------DKQETFLNISQ----MNLSYSEEEFDVLS-----------------------------------------------------------------------ESAVDFIRTLLVKKPEDRAT------AE-ECLKHPWL--------------
---YTFGRILGKGSFGIVIEATDK-----ETET--KWAI-KKVNKE-K-AGS---SA--VK-LLER-EVNILKSV-K-----HEHIIHLEQVFE--T--------PKKMY--LVMELCEDG--ELKEILD-------RKG-------------------------HF---SENETRWIIQSLASAIAYLHN-N--DIVHRDLKLENIMVK----SSLIDDNNEINLNIKVTDFGLAVKK-------------------QSRSEAML---------QA---TCGTPIYMAPEVIS-----------AHD---YSQQCDIWSIGVVMYMLLR-GEPP---------------FL-AS------------SEEKLFELIRK----GELHFENAVWNSIS-----------------------------------------------------------------------DCAKSVLKQLMKVDPAHRIT------AK-ELLDNQWL--------------
---YSILKQIGSGGSSKVFQVLNE-----KKQ---IYAI-KYVNLE-E-ADN---QT--LD-SYRN-EIAYLNKLQQ----HSDKIIRLYDYEI--T--------DQYIY--MVMECGNI---DLNSWLK-------KKK-------------------------SI---DPWERKSYWKNMLEAVHTIHQ-H--GIVHSDLKPANFLIV-----DGML---------KLIDFGIANQMQ------------------PDTTSVVK---------DS---QVGTVNYMPPEAIKDMSSSRENGKSKSK---ISPKSDVWSLGCILYYMTY-GKTP---------------FQ-QI-----------INQISKLHAIID----PNHEIEFPDIPE-------------------------------------------------------------------------KDLQDVLKCCLKRDPKQRIS------IP-ELLAHPYV--------------
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