|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK PIM1 203
Other AURKA 133
CAMK CASK 12
CMGC CDK2 4
CAMK CHEK2 220
CMGC CSNK2A1 39
CAMK DAPK1 13
AGC GRK6 186
CAMK MAPKAPK2 64
Other NEK2 8
AGC RPS6KA1 62
STE STK24 24
Other TTK 525
---YQVGPLLGSGGFGSV---YSGIRVSDNLPVAIKHVEKDR-ISDWGELPNGTRV--PMEVVLLKKV-S-SGFSGVIRLLDWFER----PDSFVLILERPEPVQDLF-DFIT----ERGALQEELARSFFWQVLEAVRHCHNC-----GVLHRDIKDENILIDLNRGEL----KLIDFGSGA----LLKDTVYTDFDGTRVYSPPEWIR----------YHRYHGRSAAVWSLGILLYDMVCGDIPFE-HD----------EEIIRGQVFFRQRVS----------------------------------SECQHLIRWCLALRPSDRPT-----FEEIQNHPWM--
---FEIGRPLGKGKFGNV---YLAREKQSKFILALKVLFKAQLEKAGVEHQLRR------EVEIQSHL-R-HPN--ILRLYGYFHD----ATRVYLILEYAPLG-TVY-RELQ----KLSKFDEQRTATYITELANALSYCHSK-----RVIHRDIKPENLLLG-SAGEL----KIADFGWSV----HAPSSRRTTLCGTLDYLPPEMIE-----------GRMHDEKVDLWSLGVLCYEFLVGKPPFE-AN----TYQETYKRISRVEFTFPDFVT----------------------------------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI--
---YELCEVIGKGPFSVV---RRCINRETGQQFAVKIVDVAK-FTSSPGLSTEDL---KREASICHML-K-HPH--IVELLETYSS----DGMLYMVFEFMDGA-DLCFEIVKR-ADAGFVYSEAVASHYMRQILEALRYCHDN-----NIIHRDVKPHCVLLA-SKENSA-PVKLGGFGVAIQL--GESGLVAGGRVGTPHFMAPEVVK-----------REPYGKPVDVWGCGVILFILLSGCLPFY-GT-----KERLFEGIIKGKYKMNPRQWSHIS------------------------------ESAKDLVRRMLMLDPAERIT-----VYEALNHPWL--
---FQKVEKIGEGTYGVV---YKARNKLTGEVVALKKIRLDT-ETEGVPSTAIR------EISLLKEL-N-HPN--IVKLLDVIHT----ENKLYLVFEFLHQ--DLK-KFMDA--SALTGIPLPLIKSYLFQLLQGLAFCHSH-----RVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILL----------GCKYYSTAVDIWSLGCIFAEMVTRRALFP-GD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF--
-YI--MSKTLGSGACGEV---KLAFERKTCKKVAIKIISKRK-FAIGSAREADPALNVETEIEILKKL-N-HPC--IIKIKNFF-D----AEDYYIVLELMEGG-ELF-DKVV----GNKRLKEATCKLYFYQMLLAVQYLHEN-----GIIHRDLKPENVLLS-SQEEDC-LIKITDFGHSKI---LGETSLMRTLCGTPTYLAPEVLVS--------VGTAGYNRAVDCWSLGVILFICLSGYPPFS-EH---RTQVSLKDQITSGKYNFIPEVWAEVS------------------------------EKALDLVKKLLVVDPKARFT-----TEEALRHPWL--
---YQLVRKLGRGKYSEV---FEAINITNNEKVVVKILKPVK-KKKIKR-----------EIKILENLRG-GPN--IITLADIVKDP--VSRTPALVFEHVNNT-DFK-QLY-------QTLTDYDIRFYMYEILKALDYCHSM-----GIMHRDVKPHNVMIDHEHRKL----RLIDWGLAEF---YHPGQEYNVRVASRYFKGPELLV----------DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGH-DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----AREAMEHPYF--
---YDTGEELGSGQFAVV---KKCREKSTGLQYAAKFIKKRR-TKSSRRGVSREDI--EREVSILKEI-Q-HPN--VITLHEVYEN----KTDVILILELVAGG-ELF-DFLA----EKESLTEEEATEFLKQILNGVYYLHSL-----QIAHFDLKPENIMLL-DRNVPKPRIKIIDFGLAHK---IDFGNEFKNIFGTPEFVAPEIVN-----------YEPLGLEADMWSIGVITYILLSGASPFL-GD----TKQETLANVSAVNYEFEDEYFSNTS------------------------------ALAKDFIRRLLVKDPKKRMT-----IQDSLQHPWI--
--F-RQYRVLGKGGFGEV---CACQVRATGKMYACKKLEKKR-IKKRKGEAMAL-----NEKQILEKV-N-SRF--VVSLAYAYET----KDALCLVLTLMNGG-DLK-FHIYH--MGQAGFPEARAVFYAAEICCGLEDLHRE-----RIVYRDLKPENILLD-DHGHI----RISDLGLAVH---VPEGQTIKGRVGTVGYMAPEVVK-----------NERYTFSPDWWALGCLLYEMIAGQSPFQ-QR-KKKIKREEVERLVK-EVPEEYSER--FS------------------------------PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF--
KVT---SQVLGLGINGKV---LQIFNKRTQEKFALKMLQDCP-KAR-------R------EVELHWRASQ-CPH--IVRIVDVYENLYAGRKCLLIVMECLDGG-ELF-SRIQD--RGDQAFTEREASEIMKSIGEAIQYLHSI-----NIAHRDVKPENLLYT-SKRPNA-ILKLTDFGFAKE---TTSHNSLTTPCYTPYYVAPEVLG-----------PEKYDKSCDMWSLGVIMYILLCGYPPFY-SNHGLAISPGMKTRIRMGQYEFPNPEWSEVS------------------------------EEVKMLIRNLLKTEPTQRMT-----ITEFMNHPWI--
---YEVLYTIGTGSYGRC---QKIRRKSDGKILVWKELDYGS-MTEAEKQMLVS------EVNLLREL-K-HPN--IVRYYDRIIDR--TNTTLYIVMEYCEGG-DLA-SVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLD-GKQNV----KLGDFGLARIL--NHDTSFAKTFVGTPYYMSPEQMN-----------RMSYNEKSDIWSLGCLLYELCALMPPFT-AF----SQKELAGKIREGKFRRIPYRY---S------------------------------DELNEIITRMLNLKDYHRPS-----VEEILENPL-I-
---FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKAT-LKVRDRVRTKM------ERDILADV-N-HPF--VVKLHYAFQT----EGKLYLILDFLRGG-DLF-TRLS----KEVMFTEEDVKFYLAELALGLDHLHSL-----GIIYRDLKPENILLD-EEGHI----KLTDFGLSKEA--IDHEKKAYSFCGTVEYMAPEVVN-----------RQGHSHSADWWSYGVLMFEMLTGSLPFQ-GK----DRKETMTLILKAKLGMPQFLS----------------------------------TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV--FY
---FTKLEKIGKGSFGEV---FKGIDNRTQKVVAIKIIDLEE-AEDEIEDIQ-Q------EITVLSQC-D-SPY--VTKYYGSYLK----DTKLWIIMEYLGGG-SAL-DLLE-----PGPLDETQIATILREILKGLDYLHSE-----KKIHRDIKAANVLLS-EHGEV----KLADFGVAGQL--TDTQIKRNTFVGTPFWMAPEVIK-----------QSAYDSKADIWSLGITAIELARGEPPHS-EL-HPMKVLFLIPKNNPPTLEGNYS------------------------------------KPLKEFVEACLNKEPSFRPT-----AKELLKHKFI--
---YSILKQIGSGGSSKV---FQVLNEKKQ-IYAIKYVNLEE-ADNQTLDSYRN------EIAYLNKLQQHSDK--IIRLYDYEIT----DQYIYMVMECGNI--DLN-SWLK----KKKSIDPWERKSYWKNMLEAVHTIHQH-----GIVHSDLKPANFLIV--DGML----KLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ-QI---INQISKLHAIIDPNHEIEFPDIPE--------------------------------KDLQDVLKCCLKRDPKQRIS-----IPELLAHPYV--
|